THROMBOCYTOPAENIA

non-immunologic platelet consumption or destruction:

disseminated intravascular coagulation

microangiopathic haemolytic anaemia

haemangiomas

mechanical destruction (prosthetic valves, vascular prosthesis)

autoimmune destruction (anti-platelet antibodies present):

idiopathic thrombocytopaenic purpura

systemic lupus erythematosus

lymphoma

drug-induced autoimmune thrombocytopaenia (heparin, sulphas)

HIV-related

infections:

measles

HIV

decreased bone marrow production:

any condition infiltrating or destroying bone marrow:

malignancies, especially haematological

aplastic anaemia

B12 or folate deficiency (with pancytopaenia)

paroxysmal nocturnal haemoglobinuria

alcohol

platelet sequestration:

hypersplenism [various causes]

dilutional:

multiple blood transfusions

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