APLASTIC ANAEMIA

(HYPOPLASTIC ANAEMIA)

congenital

Fanconi syndrome

non-Fanconi congenital aplastic anaemias

dyskeratosis congenita

acquired

(idiopathic)

2° to:

idiosyncrasy to drugs / chemicals:

chloramphenicol

tolbutamide

sulphonamides

gold

insecticides

indomethacin

phenylbutazone

benzene and derivatives

thiazides

alcohol

chemotherapy, eg. busulphan, cyclophosphamide

radiation

infection, eg. following viral hepatitis, parvovirus infection

pregnancy (very rare)

NB: presence of splenomegaly is NOT compatible with a diagnosis of aplastic anaemia

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