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SPLENOMEGALY (2) (classified according to size) click here for a list of causes classified according to pathological cause |
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marked splenomegaly (>8cm): |
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common: |
chronic myeloid leukaemia myelofibrosis + myeloid metaplasia |
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less common: |
visceral leishmaniasis chronic malaria |
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rare: |
Gaucher's disease local cyst or tumour |
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moderate splenomegaly (4-8cm): any of above |
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Felty's syndrome (= RA + lymphadenopathy + hypersplenism)lymphomas chronic haemolytic anaemias and haemoglobinopathies / thalassaemias (esp. on low transfusion regimes)polycythaemia rubra vera congestion due to portal hypertension amyloidosis Langerhans cell histiocytosis metastases (rare) |
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mild splenomegaly (<4cm): any of above |
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infective conditions, eg.subacute bacterial endocarditis, typhoid, brucellosis connective tissue diseases, eg. systemic lupus erythematosus idiopathic thrombocytopaenic purpura sarcoidosis acute leukaemias megaloblastic anaemias congestive heart failure / constrictive pericarditis |
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