SPLENOMEGALY (1)

(classified according to causes)

click here for a list of causes classified according to size

infections:

bacterial:

eg. subacute bacterial endocarditis, septicaemia, typhoid fever, brucellosis, tuberculosis

viral:

eg. EBV, CMV, rubella

protozoal:

eg. leishmaniasis, malaria, toxoplasma

other:

splenic abscess

 haematological:

lymphoproliferative disorders (CLL, hairy cell leukaemia)

myeloproliferative disorders (CML, PRV, myelofibrosis, essential thrombocythaemia)

lymphomas

idiopathic thrombocytopaenic purpura

myelodysplastic syndromes

congenital or acquired haemolytic anaemias

haemoglobinopathies and thalassaemias

congestive:

portal hypertension

splenic vein thrombosis

cardiac failure

infiltrations:

sarcoidosis

amyloidosis

lipidoses, eg. Gaucher's disease

non-lipid reticuloendothelioses

connective tissue disease:

systemic lupus erythematosus

rheumatoid arthritis / Still's disease (Felty's syndrome)

polyarteritis nodosa

neoplasms:

haemangioma

lymphangioma

metastases

lymphomas

cysts:

congenital (epidermoid cyst)

acquired (pseudocyst)

other:

serum sickness

drug hypersensitivity reactions

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