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The origin and developement of CGH is unknown. Previously, It was understood to be an autosomal dominant disorder becasue most cases seemed to involve a familial component. There seems to be no connection to hormonal or endocrinologic abnormalities. The discovery of a "multigenerational Mexican family with many members manifesting the phenoype" gave scientists a rare chance to study the characteristics of the disease. Hair growth is more appearnt in males versus females thus leading scientists to theorize that the condition is an "X-linked dominant pattern of inheritance. Using PCR scientists were recently able to localize the gene "to an interval in Xq24-q27.1 region of the X-chromosome. Some enviromental factors can induce secondary sympotoms that resemble CGH. These "exogenous medications" include "phenyton, minoxidil, cycosporine," etc. There are also some evidence that could suggest that spontaneous mutations could cause CGH. |
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