Fibronectin type III domains

FIBRONECTIN TYPE-III (FnIII) DOMAINS

Vertebrate Fibronectin precursor(Fibronectin TYPE III DOMAIN REPEATS ONLY) HUMAN . . .609 ..SGPVEVFITETPSQPNSHPIQ W NAPQPSHIS KY ILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQY... MOUSE . . .609 ..TGPVQVIITETPSQPNSHPIQ W NAPEPSHIT KY ILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYGHREVTRFDFTTSASTPVT RAT . . . .609 ..TGPVQVIITETPSQPNSHPIQ W NAPEPSHIT KY ILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYGHQEVTRFDFTTSASTPVT BOVINE . . 578 ..SGPVQVIITETPSQPNSHPIQ W SAPESSHIS KY ILRWKPKNSPDRWKEATIPGHLNSYTIKGLRPGVVYEGQLISVQH... ZFISH . . .706 ..HRPVQVIISEAGNQPNSHPIQ W NAPASAHIT QY ILKWRPKNTHIQWMEVTIPGHVNSYTIAGLKPGVTYEGQLISILRF... XENOPUS. . 612. . .PVQVIITESANFPTSHPIQ W NAPQASHIK NY ILRWKPKLKAGPWKQATIPGHLNSYTISGLKPGILYEGQLISILQYCNREVTTFDFTTT…

HUMAN . . .719 . SPLVATSESVTEITASSFVVS W VSASDTVS GF RVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISED... MOUSE . . .718 . SPVVATSESVTEITASSFVVS W VSASDTVS GF RVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTT RAT . . . .718 . SPVVATSESVTEITASSFVVS W VSASDTVS GF RVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTT BOVINE . . 661 . SPVVATSESVTEITASSFVVS W VSASDTVS GF RVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYTVNVYEISEE... ZFISH . . .712 ..PRMVDTSESVTEITSSSFVIS W VSASDTVS GF RVEYELSEEGGQTGQPMILDLPHSATSVNISELLPGRKYTVNVYEVT... XENOPUS. . 719 ..PPLVSISESVTEITASSFLVS W VSASDTVS GF RVEYELSEDGDEKRYLELPNTATSVNIPDLLPGRRYNVNVYQITEEGEKS…

HUMAN . . .810 ..APDAPPDPTVDQVDDTSIVVR W SRPQAPIT GY RIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQE... RAT . . . .809 . APDAPPDPTVDQVDDTSIVVR W SRPQAPIT GY RIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGVPRS BOVINE . . 781 ....DAPPDPTVDQVDDTSIVVR W SRPRAPIT GY RIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQE... ZFISH . . .808 ....DAPSDHEVEDVADTSIRIS W SKPLAPIT GY RVVYTPSEEGSSGSVELNLPEHSTSLTLGDLRPGVLYNISIFSVEEN... XENOPUS. . 811 . .PDAPPEHNVENVDDTSIMIK W NKPQAPIT GY RVVYSPSVEGSSTELNLPSTANSVTLTELLPGIEYNITIYAVEDSLESV…

HUMAN . . .905 .DTVPSPRDLQFVEVTDVKVTIM W TPPESAVT GY RVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHG... MOUSE . . .905 ..NVPPPTDLQFVELTDVKVTIM W TPPDSVVS GY RVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTT RAT . . . .904 .DDVPAPKDLQFVEVTDVKVTIM W TPPNSAVT GY RVDVLPVNLPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTT BOVINE . ..874 .DKVPPPRDLQFVEVTDVKITIM W TPPESPVT GY RVDVIPVNLPGEHGQRLPVSRNTFAEVTGLSPGVTYHFKVFAVNQG... ZFISH . . .903 .EEVPSPTDLQFYEVSDSKITIT W TSPSSEVS GY RVSVGEVGPDGFDEEVLSVTQNAYAEITHLQPGTLYRFFIFSLKSG... XENOPUS. . 905 .VIVPSPTDLQLVEVTDVKIIIM W TSPQSEVS GY RVVVKPVSPAGRDVQNLPVNRNTFAEVVNLQPGRTYSFEVYAVNRGQESEPLVGEFATKLDAP

HUMAN . . .996 ..KLDAPTNLQFVNETDSTVLVR W TPPRAQIT GY RLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQE... MOUSE . . .995 ..KLDAPTNLQFVNETDRTVLVT W TPPRARIA GY RLTAGLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTATLVAVKGNQQSPKATGVFTTL RAT . . . .995 ..KLDAPTNLQFVNETDRTVLVT W TPPRARIA GY RLTVGLTRGGQPKQYNVGPMASKYPLRNLQPGSEYTVTLMAVKGNQQSPKATGVFTTL BOV .. . . 965 ..KLDAPTNLQFINETDTTVIVT W TPPRARIV GY RLTVGLTRGGQPKQYNVGPAASQYPLRNLQPGSEYAVSLVAVKGNQQ... ZFISH . . .995 ...PDPQTDIYFSNITEDSAVIV W LPPTAQIT GY RLFLTVEGSNPNSCVFQPSGRSYHPSLNLQPDTEYSATLHAERGN. XENOPUS. . 997 ...LDAPTDLQFTDVTESTVVII W IPPQAKIG RY LLSVGQTRGGQPSQFPINPSVTNHKLDNLLPGTEYTVSLVALKGNQQSASASG

HUMAN . ..1085 .LQPGSSIPPYNTEVTETTIVIT W TPAPRI GF KLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQ... MOUSE . . 1085 ..QPLRSIPPYNTEVTETTIVIT W TPAPRI GF KLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTP RAT . . . 1085 ..QPLRSIPPYNTEVTETTIVIT W TPAPRI GF KLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTP BOV . . . 1054 .LQPLGSIPHYNTEVTETTIVIT W TPAPRI GF KLGVRPSQGGEAPREVTSESGSIVVSGLTPGVEYVYTISVLRDGQE... ZFISH . ..1083 .TPPMGNAPYFSTDVTDTSIIVS W SPLPKI GY KLTVRPSQGGEAPRDVTSELGSVLISGLTPGVEYTYSVQPVISGQE... XENOPUS. .1087 ...PVGSIPHYNTEVTETTIVVT W TPVPRI GF KLDVRPSQGGEAPREVISESGSIVISGLTPGVEYTYSISVLTDGVEKDIPITKTVVTPLSPPTNL

HUMAN . . 1175 ...SPPTNLHLEANPDTGVLTVS W ERSTTPDIT GY RITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVY... MOUSE . . 1173 ..LSPPTNLHLEANPDTGVLTVS W ERSTTPDIT GY RITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTVVP RAT . . . 1173 ..LSPPTNLHLEANPDTGVLTVS W ERSTTPDIT GY RITTTPTNGQQGTALEEVVHADQSSCTFENRNPGLEYNVSVYTVKDDKESAPISDTVIP BOV . . . 1141 TPLSPPTNLHLEANPDTGVLTVS W ERSTTPDIT GY RITTTPTNGQQGYSLEEVVHADQSSCTFENLSPGLEYNVSVY... CHICK . . .. 1 .PLSPPTNLRLEPNPDTGILIVS W DRSTTPGIS GY RVTTAPTNGQQGSTLEEVVGADQTSCTFENLNPGVEYNVSVYAVKDDQESIPISKTITQ ZFISH . . 1173 ...SPPTDLNLESNPNTGKLTVQ W NDANIPDIT GY RVTCTPTKGQQGNSLEEFVKAGQNSCTLENLSPGVEYNVSVF... XENOPUS. .1173 .PLSPPTNLRLQPSRDSATLTVY W DRSISPGIT GY RISTTPTPMQVGNSLEEEVGPSQTYCVFENLSPGVEYNVSVYAVKEEEESAPLS NEWT . . . .14 .PISPPTDLHLEPSPDFATLTVS W SRSPSPGIT GY RINTALLLGIRLHSGYTLEEEVTESQSRVCIFDNLSPGVEYNVSVVSVKDDQESEPIWKTITQEV

MOUSE . . 1265 ..EVPQLTDLSFVDITDSSIGLR W TPLNSSTII GY RITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQT RAT . . . 1265 ..EVPQLTDLSFVDITDSSIGLR W TPLNSSTII GY RITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQT CHICK . . . 94 ..EVPQLTDLSFVDITDSSIGLR W TPLNASTII GY RITVVAAGESVPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQT ZFISH . . 1264 ..DVPKITDLSFINVTDSTIGLS W SPLNSTAVT GY RITVLAAGDSVPIFVEFVEPTTGFYTVHGLEPGIDYDITVTTVTE... XENOPUS. .1268 . . PQLTDIKYDDVTDTSIDLR W TPLNSSNII GY RITVVAAGESVPIYEEFVGPTDGYYKVSGLEPGIDYEISLITLINGGESAPTTIIQHTAVPP NEWT . . . 113 ....PSLTDLNFVDVTDTSIDLR W TPLKGPTII GY RVTVVAAGESVPIYEDKVGPTQGYYKVSGLEPGIDYDISVITLVTDGESAPTTLTTADCC

HUMAN . . 1266 ..AVPPPTDLRFTNIGPDTMRVT W APPPSIDLT---NFLV RY SPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYE... MOUSE . . 1356 ..AVPPPTDLRFTNIGPDTMRVT W APPPSIELT---NLLV RY SPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKT RAT . . . 1356 ..AVPPPTDLRFTNIGPDTMRVT W APPPSIELT---NLLV RY SPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKT BOV . . . 1235 ..AVPPPTDLRFTNVGPDTMRVT W APPSSIELT---NLLV RY SPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVY... CHICK . . .186 ..AVPPPTDLRFTNVGPDTMRVT W TAPTSIVLS---SFLV RY SPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQHESAPLSGIQKTG ZFISH . ..1355 ..AVPAPYGLSFGEVTADTMLVT W KAPQVPKSSDINQYII RY HPVDEDDETTERTVEGSENFVVLRHLVPNTEYLVSVICVYEGR XENOPUS. .1358 ....PPPTNLRFTNIGPDNIRVT W SPPTSIELS---SYLV RY SPVKKPDDVTELSLSPSTNMVVLSNLLPFTEYLVSVHSVYESRESSS NEWT . . . 204 ....PTATDLRFTNVGPDSMLVT W SAPPSMVLS---SFLV RY VPSKNEEDAAELTISPSDNMVVLTNLLPGTEYIVSVFAVYEERESTPLTGVQRTG

HUMAN. . .1357 ..GLDSPTGIDFSDITANSFTVH W IAPRATIT GY RIRHHPEHFSGRPREDR-VPHSRNSITLTNLTPGTEYVVSIVALNGR... MOUSE . . 1547 ..GLDSPTGFDSSDITANSFTVH W VAPRAPIT GY IIRHHAEHSVGRPRQDR-VPPSRNSITLTNLNPGTEYVVSIIAVNGR RAT . . . 1447 ..GLDSPTGFDSSDVTANSFTVH W VAPRAPIT GY IIRHHAEHSAGRPRQDR-VPPSRNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQST BOV . . ..1326 ..ALDSPSGIDFSDITANSFTVH W IAPRATIT GY RIRHHPENMGGRPREDR-VPPSRNSITLTNLNPGTEYVVSIVALNSK... CHICK . ...277 ...LDSPTGLDFSDITANSFTVH W IAPRATIT GY KIRHHPEHGVGRPKEDR-VPPSRNSITLTNLLPGTEYVVSIIAVNGREESVPLVGQQTT ZFISH . ..1448 ..LFLMPCCLQFSDVGTTSFTVR W QAPRAIIS GY RIRYQMTSG-GRAKEER-LPPSRSHFTLTGLTPETEYSISVYAVSGSR... XENOPUS. .1449 . .LDSPTGIAFSEITPNSFTVH W IAPRGPIT GY RIRYQLESGAGRPKEER-VPPSRNSITLTHLIPGSEYLVSIIAINGQQESLPLAGQQATVSD NEWT . . . 294 ...LDSPTGLDFSDTTSSSFTVY W MAPRATVT GY KIQYHPETGGAGQKEERCVPPSRNSLTLTNLTPGTEYVVSIFAVNGRQESVPLVGQQATVSDT

HUMAN . ..1447 ..VSDVPRDLEVVAATPTSLLIS W DAPAVTVR YY RITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTG... MOUSE ....1537 ..VSDIPRDLEVIASTPTSLLIS W EPPAVSVR YY RITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYKT RAT . . . 1537 ..VSDVPRDLEVIASTPTSLLIS W EPPAVSVR YY RITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYQT BOV . . . 1416 ..VSDVPRDLEVIAATPTSLLIS W DAPAVTVR YY RITYGETGGSSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTG... CHICK . . .366 ..VSDVPRDLEVNPTSPTSLEIS W DAPAVTVR YY RITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRGDSPASSKPVTVTYKT ZFISH . . 1538 ...SDAPTDLEVISSTPTSITVR W DAPSVTVR YY RITHGESGGSDAPLEFMVPGSQSTATIEDLRPGTDYTITVYAVT... XENOPUS. .1539 . .SDVPTDLEVTSSSPNTLTIS W EAPAVSVR YY RITYSQTGGHGPEKEFTVPGTSNTATIRGLNPGVSYTITVYAVTGRGDSPA NEWT . . . 388 ......PTNLEVTSSTPTSMSIS W DAPPVGVR YY RITYTETGGETPVQEFTVPGDRSDAPIRGLKPGAEYIITVYAVTGRGDSPASSKPVTVTHKT

HUMAN. . .1541 ..EIDKPSQMQVTDVQDNSISVK W LPSSSPVT GY RVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNP... MOUSE. . .1631 . EIDKPSQMQVTDVQDNSISVR W LPSTSPVT GY RVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVT RAT . . . 1631 ..EIDKPSQMQVTDVQDNSISVR W LPSTSPVT GY RVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVT BOVI . . .1510 ..EIDKPSQMQVTDVQDNSISVR W LPSSSPVT GY RVTTAPKNGPGPSKTKTVGPDQTEMTIEGLQPTVEYVVSVYAQNQ... CHICK . . .460 ..EIDTPSQMQVTDVQDNSISIR W LPSSSPVT GY RVTAVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQNGESLPLVETAVT XENOPUS. .1632 ..DVDQPIDMAVTDIQDHSIHVK W SPPPGPVT GY RVTSVPKSGQGETFSQVISPDQTEVTIVGLQPAVEYVVSIYSQGENGFSEPLVETAV NEWT . . . 478 ..VVDKPTQLQVTDVQDHSIQVR W MPSSTPVT GY RVTSVPKSGVGPTVSHVVPPDQTEMTIEGLEPTVEYVVSVYAQGKNGETEPLVETAVT

HUMAN . ..1631 ..NIDRPKGLAFTDVDVDSIKIA W ESPQGQVS RY RVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALH... MOUSE . ..1721 ..NIDRPKGLAFTDVDVDSIKIA W ESPQGQVS RY RVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDMESQPLIGIQST RAT . . . 1721 ..NIDRPKGLAFTDVDVDSIKIA W ESPQGQVS RY RVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVSVVALHGGMESQPLIGVQST CHICK . ...550 ..NIDRPKGLTFTEVDVDSIKIA W ESPQGQVT RY RVTYSSPEDGIHELLPAPGGEEDTAELHGLRPGSEYTINIVAIYDDMESLPLTGTQST ZFISH . . 1631 ..DIDSPSQMEVTDVKDNTITVR W TPAAGPIS RY RVNATPLTGEGPVLHAETTSDHTEITFSGLMPAVEYSIKVYALGQD... XENOPUS. .1721 .TNIDNPKGLTFTDVGVDSIRLA W EVPDGQVT RY RVTYSSPEDGVKELFPAPEGDDDTAELHGLRPGTEYTVSIVALHDDM ZFISH . . 1721 ..TVDKPKDLSFTDVESSSMRIS W DSPDGVVS SY RVLYYSPEEGERELFPAPHGDDESAVLHGLRPGTEYTVKVIALHDQ... NEWT . . . 568 ..NIDRPKGLAFTEVDVDSLKLV W ESPKGQVT TY KVTYSNPEDGIHELVPAPNGDEDTAQLHGLRPGAEYTVSVVALHDDMESQPLIGTQVTAI

HUMAN . . 1721 ..AIPAPTDLKFTQVTPTSLSAQ W TPPNVQLT GY RVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDT... MOUSE . . 1811 . AIPAPTNLKLSQVTPTSFTAQ W IAPSVQLT GY RVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITTLE RAT . . . 1811 ..AIPAPTNLKFTQVSPTTLTAQ W TAPSVKLT GY RVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLE BOV . . . 1600 ..TIPAPTNLKFTQVTPTSLTAQ W TAPNVQLT GY RVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDT... CHICK . . .640 ..AIPPPTNLKFTQVTPTSLTVN W NAPNVRLT GY RVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYALKDSLTSRPAQGVVTTLE ZFISH . . 1811 ..GIPGPTRLQFSQVGPTSFTVS W SSSDASLT GY RVAVSPKSKSGPTKEENITPDSTEFHATGLMPGTDYEVEVYGVKN... XENOPUS. .1814 . . PAPTNLQFSQVTPSGFSLS W HAPTVHLT GY LVRVNPKEKTGPTKEVRLSPGVAATTVTGLMVATKYEVNVYALKDSLTSQPLQGLIS NEWT . . . 660 ....PPPTNLLFSQITPTSVTVS W RPPNVQLT GY RVRVHPKEKAGPMKEINLSPDSTSAVVTGLMVATKYEVSVYALKDSLTSRPAQGIVTTQENVS

HUMAN . ..1813 ..NVSPPRRARVTDATETTITIS W RTKTETIT GF QVDAVPAN-GQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND... MOUSE . . 1903 ..NVSPPRRARVTDATETTITIS W RTKTETIT GF QVDAIPAN-GQTPVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDNARSSPVIIDAST RAT . . . 1903 ..NVSPPRRARVTDATETTITIS W RTKTETIT GF QVDAIPAN-GQTPVQRTISPDVRSYTITGLQPGTDYKIHLYTLNDNARSSPVVIDAST BOV . . ..1691 .ENVSPPRRARVTDATETTITIS W RTKTETIT GF QVDAIPAN-GQTPIQRTIRPDVRSYTITGLQPGTDYKIHLYTLND... HORSE . . . 29 .....PPRRARVTDATETTITIS W RTKTETIT GF QVDAVPAN-GQPPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVIIDAST DOG . . . . 29 . . .PPRRARVTDATETTITIS W RTKTETIT GF QVDAIPAN-GQNPIQRTIRPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDAST CHICK . .. 732 ..NVSPPRRARVTDATETTITIT W RTKTETIT GF QIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENARSSPVVIDAST ZFISH . ..1903 ..NISPPRRVRISNVKDSSITLT W RSKTEAIS GF LVEATPTMGGHNPIQRTIEPDSRTYTIAGLEPGTNYKINIYTLNG... XENOPUS. .1907 . . .PPRRPRIQDVTETTVTLS W RTKTETIT GF QIDAIPAD-GQNPIRRTVDADLRTFTITGLQPGTDYKIYLYTLNDNARSSPVTVDV NEWT. . . .753 .....PPRRRRITDVTETTVTIT W RTKTETIT GF HIDAIPAG-GQNPIQRTISPDLRTYVITGLQPGTDYKIHIYTLNDNARSSPVTIDATTAV

HUMAN . ..1902 ..AIDAPSNLRFLATTPNSLLVS W QPPRARIT GY IIKYEKPGSPPREVVPRPRPGVTEATIT-GLEPGTEYTIYVIALK... MOUSE . . 1992 ..AIDAPSNLRFLTTTPNSLLVS W QAPRARIT GY IIKYEKPGSPPREVVPRPRPGVTEATIT-GLEPGTEYTIYVIALKNNQKSEPLIGRKKT RAT . . . 1992 ..AIDAPSNLRFLTTTPNSLLVS W QAPRARIT GY IIKYEKPGSPPREVVPRPRPGVTEATIT-GLEPGTEYTIYVIALKNNQKSEPLIGRKKT BOV . . ..1741 .....APSNLRFLATTPNSLLVS W QPPRARIT GY IIKYEKPGSPPREVVPRPRPGVTEATIT-GLEPGTEYTIQVIALK... HORSE . . .115 ..AIDAPSNLHFLATTPNSLLIS W QPPRARIT GY IIKYEKPGSPPREVVPRPHPGVTEATIT-GLEPGTEYTIQVIAIKNNQKSEPLIGRRKTDE DOG . . . .115 ..AIDAPSNLRFLATTPNSLLVS W QPPRARIT GY IIKYEKPGSPPREVVPRPRPGVTEATIT-GLEPGTEYTIQVIALKNNQKSEPLIGRKKTDEL CHICK . . .822 ..AIDAPSNLRFLTTTTNSLLAS W QPPRAKIT GY IIRYDKPGSPAKELLPRPRPGTTEATIT-GLEPGTEYTIYIIAVKNNQKSEPLVGRKRT ZFISH . ..1996 ..VISPPTNLHFTSLASTSISFT W EPPRSTIT GY YVTYEEAGGIPKELTPRPQAARTFASIS-GLIPGTEYIIKIVALN... XENOPUS. .1994 . .VDSPSNLRFLTTTSNSLLFT W QPPRARIT GY IIRYEKAGGLIKEHLPRLPAGTTESTLT-NLEPGTEYIIYIIAVRNNMKSEPLVGRK NEWT. . . .841 . ..DSPSNLRFLTTTSNSLLFS W QPPRSKLT GY IIKYEKPGGPVREVVPRPHPGATESQQSQNLEPGTEYTIYIIAVRSNYKSGPLVGKKRTD

HUMAN . . 2101 .HGPGLNPNASTGQEALSQTTIS W APFQDTS EY IISCHPVGTDEEPLQFRVPGTSTSATLT… MOUSE . . 2192 ..VPGLNPNASTGQEALSQTTIS W TPFQESS EY IISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALQNQRRHKVREEVVTV… RAT . . . 2191 .HVPGLNPNASTGQEALSQTTIS W TPFQESS EY IISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALHNQRRHKVREEVVTV BOV . . . 1980 .HVVGLNPNASTGQEALSQTTIS W TPFQESS EY IISCHPVGIDEEPLQFRVPGTSASATLTG… HORSE . . .313 PHVLGLNPNTSTGQEALSQTTIS W TPFQESS EY IISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEALKDQKRHKVREEVVTVGNSVDQG DOG . . . .313 PHVMGLNPNASTGQEALSQTTIS W TPFQESS EY IISCHPVGIDEEPLQFRVPGTSASATLTGLTRGATYNIIVEALKDQKRHKVREEV… ZFISH . . 2192 ...GGLFNETNLPQESQTQTTIV W QPVPHTS EY VVWCDPITEINEKSFQMRLPGTSTSATLI… XENOPUS. .2194 PHGLGPQLNDSGVQEVASHTTIS W RPELETT EY IISCHPIDHEEAPLQFRVPGTSSSATLNGLTRGATYNIVVEAQKGTDKHKVLEK NEWT . . .1051 PTSHDSGPQQVDRTGQEAQTTIS W RPLLETT EY IITCHPVGNEETPQQFTVPGTSSSATLNGLTRGATYNIIVEALKGKNKHKSRELVTV

Vertebrate Contactin(fibronectin domains) HUMAN 1 ...603 PPGPPGGLRIEDIRATSVALT W SRGSDNHSPIS KY TIQTKTILSDD W KDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAA MOUSE 1 ...605 PPGPPGGLRIEDIRATSVALT W SRGSDNHSPIS KY TIQTKTILSDD W KDAKTDPPIIEGNMESAKAVDLIPWMEYEFRVVATNTLGTGEPSIPSNRIKTDGAA RAT 1 .....605 PPGPPGGLRIEDIRATSVALT W SRGSDNHSPIS KY TIQTKTILSDD W KDAKTDPPIIEGNMESAKAVDLIPWMEYEFRVVATNTLGTGEPSIPSNRIKTDGAA BOVINE 1 ..603 PPGPPGGLRIEDIRATSVALT W SRGSDNHSPIS KY TIQTKTILSDD W KDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGIGEPSIPSNKIKTDGAA ZFISH 1 ...616 PPGPPGGVRVDEVTSDSVRVL W SHGTDNLSPIS RY TVQLRESAAQQDW RDAATSPVNVEGNAEMATVVNLLPWTEYEFRVIATNTLGTGPPSEPSPKTTTREAR CHICK 1 ...594 PPGPPGGIRIEEIRDTAVALT W SRGTDNHSPIS KY TIQSKTFLSEE W KDAKTEPSDIEGNMESARVIDLIPWMEYEFRIIATNTLGTGEPSMPSQRIRTEGA HUMAN 2 ...607 PPGPPGGVVVRDIGDTTIQLS W SRGFDNHSPIA KY TLQARTPPAGK W KQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAA RAT 2 .....609 PPGPPGGVVVRDIGDTTVQLS W SRGFDNHSPIA KY TLQARTPPSGK W KQVRTNPVNIEGNAETAQVLGLMPWMDYEFRVSASNILGTGEPSGPSSKIRTKEAV ZFISH 2 ...608 PPGPPGGLVVTSVNDTSVELR W SRGYDNHSPIG KY VILGRSSQTHD W KRMRTDPANIEGNAESARVIDLRPWMDYEFQVIASNILGSGEPSMPSPRAQTKEAA CHICK 2 ...602 PPGPPGGVVVRDIGDTTVQLS W SRGFDNHSPIA RY SIEARTLLSNK W KQMRTNPVNIEGNAETAQVVNLIPWMDYEFRVLASNILGVGEPSLPSSKIRTKEAA MOUSE 3 ...598 .PGPPENVKVDEITDTTAQLS W TEGTDSHSPVI SY AVQARTPFSVG W QSVRTVPEVIDGKTHTATVVELNPWVEYEFRIVASNKIGGGEPSLPSEKVRTEEAA RAT 3 .....597 SPGPPENVKVDEITDTTAQLS W TEGTDSHSPVI SY AVQARTPFSVG W QNVRTVPEAIDGKTRTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAA HUMAN 4 ...596 PPGPPEAVTIDEITDTTAQLS W RPGPDNHSPIT MY VIQARTPFSVG W QAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEAL HUMAN 5 ...596 PPGPPGIVIVEEITESTATLS W SPAADNHSPIS SY NLQARSPFSLG W QTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAV RAT 5 .....670 PPGPPGVVIVEEITESTATLS W SPATDNHSPIS SY NLQARSPFSLG W QTVKTVPEVITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSIPSRMIRTNEAV HUMAN 6 ...597 PPGPPEDVQVEDISSTTSQLS W RAGPDNNSPIQ IF TIQTRTPFSVG W QAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASV MOUSE 6 ...597 PPGPPEDVKVEHISSTTSQLS W RPGPDNNSPIQ IF TIQTRTPFSVG W QAVATVPEILNGQTYNATVVGLSPWVEYEFRVVAGNNIGIGEPSKPSELLRTKASV RAT 6 .....597 PPGPPEDVKVEHISSTTSQLS W RPGPDNNSPIQ IF TIQTRTPFSVG W QAVATVPEILNGQTYNATVIGLSPWVEYEFRVVAGNNIGIGEPSKPSELLRTKASI

HUMAN 1 ...706 PNVAPSDVGGGGGRNRELTIT W APLSREYHYGNNF GY IVAFKPFDGEE W KKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDA MOUSE 1 ...708 PNVAPSDVGGGGGTNRELTIT W APLSREYHYGNNF GY IVAFKPFDGEE W KKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDA RAT 1 .....708 PNVAPSDVGGGGGTNRELTIT W APLSREYHYGNNF GY IVAFKPFDGEE W KKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGDGPYSLIAVINSAQDA BOVINE 1 ..706 PNVAPSDVGGGGGSNRELTIT W APLSREYHYFNNF GY IVAFKPFDGEE W KKVTVTNPDTGRYVHKDETMRPSTAFQVKVKAFNNKGDGPYSLTAVIHSAQDA ZFISH 1 ...720 PIVAPSDIGGGGGTSRELTIT W TPVQSQYYYGSNF GY IIAFKPHNDPE W LRVTVTDPEAQKYVHKDPKIPPSTRFEVKMKAFNSQGEGPFSNSAFIYSAQDV CHICK 1 ...697 PNVAPSDVGGGGGSNRELTIT W MPLSREYHYGNNF GY IVAFKPFGEKE W RRVTVTNPEIGRYVHKDESMPPSTQYQVKVKAFNSKGDGPFSLTAVIYSAQDA HUMAN 2 ...710 PSVAPSGLSGGGGAPGELIVN W TPMSREYQNGDGF GY LLSFRRQGSTH W QTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE MOUSE2’ ... 49 PSVAPSGLSGGGGAPGELTIN W TPMSREYQNGDGF GY LLSFRRQGSSS W QTARVPGADTQYFVYSNDSIHPYTPFEVKIRSYNRRGDGPESLTAIVYSAEEE MOUSE2* ...705 PTVAPSGLGGGGGAPNELIIN W TPTLRDYQNGDGF GY ILSFRKKGTQG W LTARVPHAESLHYVYRNESIGPYTPFEVKIKAYNRKGEGPESLTAIVYSAEEE RAT 2 .....712 PSVAPSGLSGGGGAPGELIIN W TPVSREYQNGDGF GY LLSFRRQGSSS W QTARVPGADAQYFVYGNDSIQPYTPFEVKIRSYNRRGDGPESLTALVYSAEEE ZFISH 2 ...711 PTVAPSGLGGGGGNRNELIIT W TPMAREYQNGDSF GY ILAFRKQGIPT W TVVKVPNVESSRYVYSNDSLTAYCPFEVRIKAYNKKGEGPFSQIAVVHSAEEE CHICK 2 ...705 PTVAPSGLGGGGGAPNELIIN W TPTLRDYQNGDGF GY ILSFRKKGTQG W LTARVPHAESLHYVYRNESIGPYTPFEVKIKAYNRKGEGPESLTAIVYSAEEE MOUSE 3 ...700 PEIAPSEVSGGGGSRSELVIT W DPVPEELQNGGGF GY VVAFRPLGVTT W IQTVVTSPDNPRYVFRNESIVPFSPYEVKVGVYNNKGEGPFSPVTTVFSAEEE RAT 3 .....700 PEVAPSEVSGGGGSRSELVIT W DPVPEELQNGGGF GY VVAFRPLGVTT W IQTVVTSPDNPRYVFRNESIVPFSPYEVKVGVYNNKGEGPFSPVTTVFSAEEE HUMAN 4 ...699 PEVTPANVSGGGGSKSELVIT W ETVPEELQNGRGF GY VVAFRPYGKMI W MLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEE HUMAN 5 ...699 PKTAPTNVSGRSGRRHELVIA W EPVSEEFQNGEGF GY IVAFRPNGTRG W KEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE RAT 5 .....773 PKTAPSNVSGGSGRRHELVIA W EPVSEEFQNGEGF GY IVAFRPNGTRG W KEKMVTSSDASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGE HUMAN 6 ...700 PVVAPVNIHGGGGSRSELVIT W ESIPEELQNGEGF GY IIMFRPVGSTT W SKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDE MOUSE 6 ...700 PNVAPGNINGGGGSRSELVIT W EAIPEELQNGEGF GY IVMFRPVGTTA W MKERVALVESSKFIYRNESIMPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDE RAT 6 .....700 PNVAPVNINGGGGSRSELVIT W EPIPEELQNGEGF GY IIMFRPVGSTT W MKEKVALVESSKFIYRNESIMPLSPFEVKVGVYNNEGEGSLSTVSIVYSGEDE

HUMAN 1 ...808 PSEAPTEVGVKVLSSSEISVH W EHVLE----KIVE SY QIRY W AAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKA MOUSE 1 ...810 PSEAPTEVGVKVLSSSEISVH W KHVLE----KIVE SY QIRY W AGHDKEAAAHRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKA RAT 1 .....810 PSEAPTEVGVKVLSSSEISVH W KHVLE----KIVE SY QIRY W AGHDKEAAAHRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKA BOVINE 1 ..808 PSEAPTAVGVKVLSSSEISVH W EHVVE----KIVE SY QIRY W ASHDKEAAAHRVQVASQEYSARLENLLPDTQYFVEVRACNSAGCGPPSDMTETFTKKA ZFISH 1 ...822 PAEAPIITEARALSATEAIVI W VPVQLP----TVE RY QVRY W RESVENEASAQRVLVSSRENHTRLDNMKPDSHYLVEVRACNGAGYGPASQRNRIYTKKSPPSR CHICK 1 ...799 PTEVPTDVSVKVLSSSEISVS W HHVTE----KSVE GY QIRY W AAHDKEAAAQRVQVSNQEYSTKLENLKPNTRYHIDVSAFNSAGYGPPSRTIDIITRKA HUMAN 2 ...811 PRVAPTKVWAKGVSSSEMNVT W EPVQQ-DMNGILL GY EIRY W KAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMK MOUSE2’ ...151 PKVAPAKVWAKGSSSSEMNVS W EPVLQ-DMNGILL GY EIRY W KAGDKERAADRVRTAGLDSSARVTGLN MOUSE2* ...807 PKVAPFRVTAKAVLSSEMDVS W EPVEQGDMTGV-L GY EIRY W KDGDKEEAADRVRTAGLVTSAHVTGLNPNTKYHVSVRAYNRAGAGPPSPSTNITTTKPP RAT 2 .....814 PRVAPAKVWAKGSSSSEMNVS W EPVLQ-DMNGILL GY EIRY W KAGDNEAAADRVRTAGLDTSARVTGLNPNTKYHVTVRAYNRAGTGPASPSADAMTVK ZFISH 2 ...813 PTVSPRWINATALTAFEIQVS W EPIQHLNINGVLR GY EIRY W RQHEREAAADRVRTAGLENTARVTGLRPNTLYHITVLAYNSAGTGPASPRTTVITKK CHICK 2 ...807 PKVAPFRVTAKAVLSSEMDVS W EPVEQGDMTGVLL GY EIRY W KDGDKEEAADRVRTAGLVTSAHVTGLNPNTKYHVSVRAYNRAGAGPPSPSTNITTTK MOUSE 3 ...802 PTVAPSHISAHSLSSSEIEVS W NTIPWKLSNGHLL GY EVRY W NNGGEEESSRKVKVAGNQTSAVLRGLKSNLAYYTA-VRAYNSAGAGPFSATVNATTKKT RAT 3 .....802 PTVAPSHISAHSLSSSEIEVS W NTIPWKSSNGRLL GY EVRY W NNGGEEESSSKVKVAGNQTSAVLRGLKSNLAYYTAVRAYNTAGAGPFSATVNATTKKT HUMAN 4 ...801 PTKPPASIFARSLSATDIEVF W ASPLEK-NRGRIQ GY EVKY W RHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPP HUMAN 5 ...801 PSAAPTDVKATSVSVSEILVA W KHIKE--SLGRPQ GF EVGY W KDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKS RAT 5 .....875 PTAAPTDVTATSVSVSEIFVV W KHVKE--SLGRPQ GF EIGY W KDTEPEDSAETVRTRGNESFVMLTGLEGDTLYHLTVRAYNGAGYGPPSREVSATTK RH HUMAN 6 ...802 PQLAPRGTSLQSFSASEMEVS W NAIAWNRNTGRVL GY EVLY W TDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKS MOUSE 6 ...802 PQLAPRGTSVQSFSASEMEVS W NAIAWNRNTGRVL GY EVLY W TDNSKESMIGKIRVSGNVTTKNITGLRANTIYFASVRAYNTAGTGPSSLPVNVTTKKS RAT 6 .....802 PRLAPRGTSVQSFSASDMEVS W NAIAWNRNTGRVL GY EVLY W TDNSKESMIGKIRVSGNVTTKNITGLRANTIYFASVRAYNTAGTGPSSPPVNVTTKKS

HUMAN 1 ...904 PPSQPPRIISSVRSGSRYIIT W DHVVALSNESTVT GY KVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSP MOUSE 1 ...906 PPSQPPRIISSVRSGSRYIIT W DHVVALSNESTVT GY KILYRPDGQHDGKLFSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGVSTL RAT 1 .....906 PPSQPPRIISSVRSGSRYIIT W DHVVALSNESTVT GY KILYRPDGQHDGKLFSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGVSTL BOVINE 1 ..904 PPSQPPRIISSVRSGSRYIIT W DHVVALSNESTVT GY KVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQV ZFISH 1 ...923 ..PPKIISTKMHYSGTSINIA W EKVESLNNESTVA GY KVLYRQHGQPSGTLYTTEKQSIDLPMRRGEYLVEVRAHSEGGDGAVAQVRITGSAPAPALASA CHICK 1 ...895 PPSQRPRIISSVRSGSRYIIT W DHVKAMSNESAVE GY KVLYRPDGQHEGKLFSTGKHTIEVPVPSDGEYVVEVRAHSEGGDGEVAQIKISGATAGV HUMAN 2 ...911 PPRRPPGNISWTFSSSSLSIK W DPVVPFRNESAVT GY KMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMV RAT 2 .....913 PPRRPPGNISWTFSSSSLSLK W DPVVPLRNESTVT GY KMLYQNDLHPTPTLHLTSKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSM ZFISH 2 ...913 PPNRPPGNVSWKVDGSWVTVR W DHVKSMDNESAVL GY KVLYKHEGQSALKVLEKSKTSVKLPLPKDNGYVVLEIRSWGDGGDGAAHETIVSRDSGTGM CHICK 2 ...907 PPRRPPGNISWTLTGSTVTIK W DPVVAQADESAVT GY KMLYRQDSHSAPTLYLASKSRIDIPVPEDFTHAFVQIRVTGPGGDGTPAEVHIVRNS MOUSE 3 ...902 PPSQPPGNVVWNATDTKVLLN W EQVKAMENESEVT GY KVFYRTSSQNNVHVLNTNKTSAELLLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDAR RAT 3 .....902 PPSQPPGNVVWNATDTKVLLN W EQVKALENESEVT GY KVFYRTSSQNNVQVLNTNKTSAELLLPIKEDYIIEVKATTDGGDGTSSEQIRIPRITSMDAR HUMAN 4 ...901 PSQPPGNIIW NSSDSKIILN W DQVKALDNESEVK GY KVLYRWNRQSSTSV IETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGS HUMAN 5 ...899 PPSQAPSNLRWEQQGSQVSLG W EPVIPLANESEVV GY KVFYRQEGHSNSQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPS RAT 5 .....973 PPSEPPGNLRWEQQGSQVSLG W EPVRPLANESEVM GY KVFYRQEGHSKGQVIETQKPQAVVPLPEAGVYIIEVRAYSEGGDGTASSQIRVPSYAGGKI HUMAN 6 ...902 PPSQPPANIAWKLTNSKLCLN W EHVKTMENESEVL GY KILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSR MOUSE 6 ...902 PPSQPPANIAWKLSNSKLCLN W EHVKTMENESEVL GY KILYRQNRQSKTHILETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSST RAT 6 .....902 PPSQPPANIAWKLSNSKLCLN W EHVKTMENESEVL GY KILYRQNRQSKTHVLETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSSEEIRIPKMSSLSSV

NeogeninHuman Neogenin precursor. Q92859 GI:12643791 / Chick Neogenin. Q90610 GI:10720134 / mouse Neogenin precursor. P97798 GI:10720133 / rat Neogenin precursor. P97603 GI:10720132 zebrafish neogenin [Danio rerio] a DCC related netrin receptor AAK33004.1 GI:23428357 c.elegans Neogenin (154.4 kD) UNCoordinated locomotion (unc-40/UNC-91) NP_491664.1 GI:17509399

hNEOGEN ...439..PSAPRDVVASLVSTRFIKLT W RTPASDPHGDNL TY SVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL mNEOGEN ...470..PSAPRDVVASLVSTRFIKLT W RTPASDPHGDNL TY SVFYTKEGVDRERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQL RATNEO ... 408..PSAPRDVVASLVSTRFIKLT W RTPASDPHGDNL TY SVFYTKEGVARERVENTSQPGEMQVTIQNLMPATVYIFKVMAQNKHGSGESSAPLRVETQPEVQL CHICKNEO ..425..PTAPRDVVATLVSTRFIRLT W RTPVSDPQGDNL TY SIFYTKEGINRERVENTSRPGETQVMIQNLMPETVYVFRVVAQNKHGHGESSAPLKVATQPEVQL ZFISHNEO ..420..PSAPRDVVASLVSTRFLKLT W RLPA-EPHGDDV TY SVYYSLEGTNRERIVNTSRPGEMQVTIQNLMPDTKYAFRVVAHNKNGPGESSVPLKVETQPEVQV C.EL.NEO ..440..PSAPLGLRSTSSGSRFINVE W DPPVQR-NGNIM RY HIFYKDNLIDRERMINSSSTSATLTSLQPSTMYLIRVTAENEAGMGKFSDSLKVTTNKEQAV

hNEOGEN ...539..PGPAPNLRAYAASPTSITVT W ETPVSGNGEIQ NY KLYYMEKGTDKEQDVDVSSHSY---TINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDV mNEOGEN ...570..PGPAPNIRAYATSPTSITVT W ETPLSGNGEIQ NY KLYYMEKGTDKEQDIDVSSHSY---TINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDV RATNEO .. .508. PGPAPNIRAYATSPTSITVT W ETPLSGNGEIQ NY KLYYMEKGTDKEQDVDVSSHSY---TINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDV CHICKNEO ..525. PGPAPNIRAYAGSPTSVTVT W ETPLSGNGEIQ NY KLYYMEKGQDSEQDVDVAGLSY---TITGLKKYTEYSFRVVAYNKHGPGVSTQDVVVRTLSDV ZFISHNEO ..519. PGPAPNLHAVVMSPSTVSLS W DVPLIGNGEIQ NY KIYYMEKGMDSEQDLDVNTLSY---TMTGLKKFTEYSFRLVAYNKHGPGVSTEDISVRTYSDV C.EL.NEO ..536. PGKVASLTTTATGPETIDIR W S-PPSGGQPAL RY KIFYSHDPLEKNEKETLITTSTTHYTLHGMDKYTGYQIRIEAEGSNGSGLSSDTVKVRTQSDE

hNEOGEN... 633 PSAAPQNLSLEVRNSKSIMIH W QPPAPATQNGQIT GY KIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRV mNEOGEN... 664 PSAAPQNLSLEVRNSKSIVIH W QPPSSTTQNGQIT GY KIRYRKASRKSDVTETLVTGTQLSQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETFESDLDETRV RATNEO.. . 602 PSAAPQNLSLEVRNSKSIVIH W QPPSSATQNGQIT GY KIRYRKASRKSDVTETVVTGTQLSQLIEGLDRGTEYNFRVAALTVNGTGPATDWLSAETFESDLDESRV CHICKNEO.. 619 PSAAPQNLTLEARNSKSIMLH W QPPPAGTHSGQIT GY KIRYRKVSRKSDVTESV-GGTQLFQLIEGLERGTEYNFRIAAMTVNGTGPATDWVSAETFESDLDESRV ZFISHNEO.. 613 PSSPPQNMTVEVLNSKSLMIR W QPPPADAQNGEIT GY KIRYRKGTRKSEVAE-ITSGSQLYQLIDGLQRGTEYMLRVSAMTVNGTGPATDWTTAETFESDLDESRV C.EL.NEO.. 632 PSAPPVNIQAEADSSTSVRVS W DEPEEESVNGEIT GY RLKYKTKARGAKGNTLVIDATAREYTMGNLEPNTQYLIRMAVVNHNGTGPFSDWVSIDTPGQDKEERTL

hNEOGEN ...739 ..PEVPSSLHVRPLVTSIVVS W TPPENQNIVVR GY AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTS--EVDL mNEOGEN ...770.. PEVPSSLHVRPLVTSIVVS W TPPENQNIVVR GY AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTS--EVDL RATNEO .. .708.. PEVPSSLHVRPLVTSIVVS W TPPENQNIVVR GY AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTS--EVDL CHICKNEO ..724.. PEVPSSLHVRPLVTSIVVS W TPPENQNIVVR GY AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHSDTS--EVDL ZFISHNEO ..718.. PDVPSSLHVRSLVNSIVVS W TPPENQDIVVR GY SISYGIGSPHAQTIKVDYKQRYYTIENLNPNSHYVITLKAFNNVGEGIPVYESAITRPQSDPIDPDVDL C.EL.NEO ..738 ...GAPREIRPHAGIDYILVS W LPPADEQNLVR GY QIGWGLSVPDTETIRVTASTTQYKIARLHSERDYVISLRAFNNLGSGFPIYETVRTLSRETPSH

hNEOGEN ...853 PMMPPVGVQASILSHDTIRIT W ADNSLPKHQKITDSR YY TVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSV-MVTKGRRSSTWSMTAHGTTFELVPTS mNEOGEN ...884 PMMPPVGVQASILSHDTIRIT W ADNSLPKHQKITDSR YY TVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSV-MVTKGRRSSTWSMTAHGATFELVPTS RATNEO .. .862 PMMPPVGVQASILSHDTIRIT W ADNSLPKHQKITDSR YY TVRWKTNIPANTKYKNANATTLSYLVTGLKPNTLYEFSV-MVTKGRRSSTWSMTAHGATFELVPTS CHICKNEO ..838 PMMPPVGVQASILSHDTIRIT W ADNSLPKNQKITDAR YY TVRWKTNIPANTKYKTANATTLSYLVTGLKPNTLYEFSV-MVTKGRRSSTWSMTAHGTTFELVPTS ZFISHNEO ..835 PMLPPVGVQASVLNQDTIKVT W ADNSLPKNQKITDAR YY TVRWKTNIPANTKFKVANTTTLFHTVTGLKPNTLYEFSV-MVTKGRRTSTWSMTAHGTTFESIPSS C.EL.NEO ..852 ....PVGVRAEAISATSIRVM W TESDETAFNT----- QY TVRYSTAVDGNQHRYV-NSTETWATVEGLRPATEYEFAVRAVASNGQLSTWSMATRNRTLAAPPSSA

hNEOGEN ...957..PPKDVTVVSKEGKPKTIIVN W QPPSEANGKIT GY IIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTP mNEOGEN ...988..PPKDVTVVSKEGKPRTIIVN W QPPSEANGKIT GY IIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTP RATNEO .. .926..PPKDVTVVSKEGKPRTIIVN W QPPSEANGKIT GY IIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT CHICKNEO ..942..PPKDVTVVSKEGKPRTIIVN W QPPSEANGKIT GY IIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRTP ZFISHNEO ..939..PPKDVTVVSKEGRPKTIIVN W QPPSEANGKIT GY IIYYSTDVKAEVHDWVIEPVVGNRLTHQIQELTLDTTYYFKIQARNSKGMGPMS C.EL.NEO ..948..PRDLTVLPAESGDPHSSSLH W QPPKYSNGEIE EY LVFYTDRASLADKDWTINYVAGDKLSHQVSNLLPKANYFFKIQARNEKGHGPFS

Human & Mouse Myomesin 1 & 2HMYOM1 ....374. PAAPLDVKCLEANKDYIIIS W KQPAVDGGSPIL GY FIDKCEVGTDS W SQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKMGIGFPS MMYOM1 ....489 .PAAPLDVVSLDANKDYIIIS W KQPAVDGGSPIL GY FIDKCEVGTDT W SQCNDTPVKFARFPVTGLIEGRSYIFRVRAVNKTGIGLPS HMYOM2 ....383 .PGAPMDLQCHDANRDYVIVT W KPPNTTTESPVM GY FVDRCEVGTNN W VQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPS MMYOM2 ....383 .PGAPMDLQCHDANRDYVIVT W KPPNTTTESPVI GY FIDKCEVGTNN W VQCNDAPVKICKYPVTGLFEGRSYVFRVRAVNNAGISRPS

HMYOM1 ....501 .PGPPTDLSVTEATRSYVVLS W KPPGQRG-HEGI MY FVEKCEAGTEN W QRVNTELPVKSPRFALFDLAEGKSYCFRVRCSNSAGVGEPS MMYOM1 ....617 .PGPPTDLSVTEATRSYVVLS W KPPGQRG-HEGI MY FVEKCDVGAEN W QRVNTELPVKSPRFALFDLVEGKSYRFRVRCSNSAGVGEPS HMYOM2 ....511 .PGPPTGVHASEISRNYVVLS W EPPTPRG-KDPL MY FIEKSVVGSGT W QRVNAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEIT MMYOM2 ....511 .PGPPTNVQASEVSRNYVVLS W DPPSPRG-KDPL MY FIEKSAVGSGS W QRVNAQTAVRSPRYAVFDLAEGKSYVFRVLSANKHGLSDPSEIT

HMYOM1 ....602 .PKAPGKIIPSRNTDTSVVVS W EESKDA--KELV GY YIEANVAGSGK W EPCNNNPVKTHRFTCHGLVTGQSYIFRVRAVNAAGLSEYS MMYOM1 ....718 .PKAPGKIIPSRNTDTSVVVS W EESRDA--KELV GY YIEASVVGSGK W EPCNNNPVKGSRFTCHGLTTAQSYIFRVRAVNAAGLSEYS HMYOM2 ....612 .PSAPGRVLASRNTKTSVVVQ W DRPKHE--EDLL GY YVDCCVAGTNL W EPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQ MMYOM2 ....612 .PSAPGRVLASRNTKTSVVVQ W DRPKHE--EDLL GY YVDCCVAGTNM W EPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGTSENSQ

HMYOM1 ....701 .PSPPCDITCLESFRDSMVLG W KQPDKTGGAEIT GY YVNYREVIDGVPGK W REANVKAVREEAYKISNLKENMVYQFQVAAMNMAGLGAPS MMYOM1 ....915 .PSAPYDITCLESFRDSMVLG W KQPDTTGGAEIT GY YVNYREVVGEVPGK W REANIKAVSDAAYKISNLKENTLYQFQVSAMNIAGLGAPS RATSIM1.....01 .PSPPYDITCLESFRDSMVLG W KQPDKTGGAEIT GY YVNYREVVGGVPGK W REANIKAVSDAAYKISELKENTVYQFQVSAMNIAGLGA HMYOM2 ....711 .PSHPYGITLLNCDGHSMTLG W KVPKFSGGSPIL GY YLDKREV---HHKN W HEVNSSPSKPTILTVDGLTEGSL MMYOM2 ....711 .PSHPYGITLLNCDGHSMTLG W KVPKFSGGSAII GY YLDKREV---HHKN W HEVNSSPVKERILTVEGLTEGSLYEFKIAATNLAGIGQPSD

HMYOM1 ....806 .PGPPHSLKCSEVRKDSLVLQ W KPPVHSGRTPVT GY FVDLKEK-AKEDQ W RGLNEAAIKNVYLKVRGLKEGVSYVFRVRAINQAGVGKPSDLAGPVV MMYOM1 ...1020 .PGPPHSVKLSEVRKNSLVLQ W KPPVYSGRTPVT GY FVDLKEASAKDDQ W RGLNEAAIVNKYLRVQGLKEGTCYVFRVRAVNQAGVGKPS RATSIM ....206 .PGPPHSLKLSEVRKNSLVLQ W KPPVYSGRTPVT GY FVDLKEASAKDDQ W RGLNEAAIPNKYLRVQGLKEGISYVFRVRAINQAGVGKPSDLAGPV HMYOM2 ....813 .PGPAYDLTFCEVRDTSLVML W KAPVYSGSSPVS GY FVDFREEDA--GE W ITVDQTTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSD MMYOM2 ....813 .PGPAYDLTFCEVRDTSLVIL W KAPVYSGSSPVS GY FVDFKEEDS--GE W KTTSEAATPNRYLKVCDLQQGKTYVFRIRAVNASGPGKPSD

Integrin beta-4 HUMAN ....1127. LGAPQNPNAKAAGSRKIHFN W LPPS---GKPM GY RVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCR RAT ......1129. LGAPQNPNAKAAGSRKIHFN W LPPP---GKPM GY RVKYWVQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAHGEGPYS MOUSE ....1125. LGAPQNPNAKAAGSRKIHFN W LPPP---GKPM GY RVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVS CRTHQEV

HUMAN ....1220 .PSEPGRLAFNVVSSTVTQLS W AEPAETNGEIT AY EVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAI RAT ......1222 .PSEPGRLAFNVVSSTVTQLS W AEPAETNGEIT AY EVCYGLVNEDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGP MOUSE ....1218 .PSEPGRLAFNVVSSTVTQLS W AEPAETNGEIT AY EVCYGLVNEDNPRTHWTYEEGARGQPQEPDAAH

HUMAN ....1528 .PDTPTRLVFSALGPTSLRVS W QEPRC-ERPLQ GY SVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVI RAT ......1512. PDTPTRLVFSALGPTSLKVS W QEPQC-DRALL GY SVEYQLLNGGEMHRLNIPNPGQTSVVVEDLLPNHSYVFRVRAQSQEGWGRE.

HUMAN ....1641. PSAPGPLVFTALSPDSLQLS W ERPRRPNGDIV GY LVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGII RAT ......1625. PSAPGPLVFTALSPDSLQLS W ERPRRPNGDIL GY LVTCEMAQGGGPARTFRVDGDNPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIES

Cytokine receptor common gamma chain precursor (Gamma-C)humang2 ...151 LVIPWAPENLTLHKLSESQLELN W NNRFL-NHCLEHLV QY RTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSN bovineg2 ..158 LVIPWAPENLTLRNLSEFQLELS W SNRYL-DHCLEHLV QY RSDRDRSWTEQSVDHRHSFSLPSVDAQKLYTFRVRSRYNPLCGSAQHWSDWSYPIHWGSN dogg2 .....151 LVIPWAPENLTLHNLSESQLELS W SNRHL-DHCLEHVV QY RSDWDRSWTEQSVDHRNSFSLPSVDGQKFYTFRVRSRYNPLCGSAQRWSEWSHPIHWGSN mouseg2 ...151 LVIPRAPENLTLSNLSESQLELR W KSRHIKERCLQYLV QY RSNRDRSWTELIVNHEPRFSLPSVDELKRYTFRVRSRYNPICGSSQQWSKWSQPVHWGSH

Interleukin-6 receptor beta chainsHUMAN6Rb ..223 NPPHNLSVINSEELSSILKLT W TNPSIKSVIILKYNI QY RTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYED MOUSE6Rb ..221 TPPYNLSVTNSEELSSILKLS W VSSGLGGLLDLKSDI QY RTKDASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYED RAT6Rb ....222 SPPHNLSVTNSEELSSILKLA W VNSGLDSILRLKSDI QY RTKDASTWIQVPLEDTVSPRTSFTVQDLKPFTEYVFRIRSIKENGKGYWSDWSEEASGTTYED

HUMAN6Rb ..325 RPSKAPSFWYKIDPSHTQGYRTVQLV W KTLPPFEANGKIL DY EVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPAC MOUSE6Rb ..323 RPSRPPSFWYKTNPSHGQEYRSVRLI W KALPLSEANGKIL DY EVILTQSKSVSQTYTVTGTELTVNLTNDRYVASLAARNKVGKSAAAVLTIPSPHVT RAT6Rb ....324 RPSKAPSFWYKVNANHPQEYRSARLI W KTLPLSEANGKIL DY EVVLTQSKSVSQTYTVNGTELIVNLTNNRYVASLAARNVVGKSPATVLTIPGSHFKA

HUMAN6Rb ..420 DFQATHPVMDLKAFPKDNML W VEWTTPRESVK KY ILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQA MOUSE6Rb ..421 ...AAYSVVNLKAFPKDNLL W VEWTPPPKPVS KY ILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGPGGSESLKAYLKQA RAT6Rb .. .423 .SHPVVDLKAFPKDNLLWVE W TPPS---KPVN KY ILEWCVLSENSPCIPDWQQEDGTVNRTHLRGSLLESKCYLITVTPVFPGGPGSPESMKAYLKQA

HUMAN6Rb ..518 PPSKGPTVRTKKVGKNEAVLE W DQLPVDVQNGFIR NY TIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKF MOUSE6Rb ..516 APARGPTVRTKKVGKNEAVLA W DQIPVDDQNGFIR NY SISYRTSVGKEMVVHVDSSHTEYTLSSLSSDTLYMVRMAAYTDEGGKDGPEFTFTTPKF RAT6Rb ....517 APSKGPTVRTKKVGKNEAVLE W DHLPVDVQNGFIR NY SISYRTSVGKEMVVRVDSSHTEYTLSSLSSDTLYMVHMAAYTEEGGKDGPEFTFTTLKF

Interleukin-7 receptor alphaHUMAN .....128 KPEAPFDLSVIYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSY MOUSE .....128 KAEAPSDLKVVYRKEANDFLVTFNAPHLKKKYLKKVKHDVAYRPARGESNWTHVSLFHTRTTIPQRKLRPKAMYEIKVRSIPHNDYFKGFWSEWSPSS

INTERLEUKIN-9 RECEPTOR PRECURSORHUMAN9R ...150 PSDLQSNISSGHCILT W SISPALEPMTTLL SY ELAFKKQEEAWEQAQHRDHIVGVTWLILEAFELDPGFIHEARLRVQMATLEDDVVEEERYTGQ MOUSE9R ...149 PSDLQSNVSSGRCVLT W GINLALEPLITSL SY ELAFKRQEEAWEARHKDRIVGVTWLILEAVELNPGSIYEARLRVQMTLESYEDKTEGEYYKS

Interleukin-12 RECEPTOR beta-1 chainsHUMANb1 ....43 .SASGPRDLRCYRISSDRYECS W QYEGPTAGVSHFLRCCLSSGRCCYFAAGSATRLQFSDQAGVSVLYTVTLWVESWARNQTEKSPEVTLQLYNSV HUMANb1 ...138 .KYEPPLGDIKVSKLAGQLRME W ETPDNQVGAEVQFRHRTPSSPWKLGDCGPQDDDTESCLCPLEMNVAQEFQLRRRQLGSQGSSWSKWSSPVCVPPENP HUMANb1 ...237 .PQPQVRFSVEQLGQDGRRRLTLKEQPTQLELPEGCQGLAPGTEVTYRLQLHMLSCPCKAKATRTLHLGKMPYLSGAAYNVAVISSNQFGPG LNQTWHIPAD HUMANb1 ...338 .THTEPVALNISVGTNGTTMY W PARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPDPAGMATYSWSRESGAMGQEKCYYITIFASAHPEKLTLWSTVLS

humanb1 ...446 .AGTPHHVSVKNHSLDSVSVD W APSLLSTCPGVLK EY VVRCRDEDSKQVSEHPVQPTETQVTLSGLRAGVAYTVQVRADTAWLRGVWSQPQRFSIE mouseb1 ...467 .AGTPRHVSVRNQTGDSVSVE W TASQLSTCPGVLT QY VVRCEAEDGAWESEWLVPPTKTQVTLDGLRSRVMYKVQVRADTARLPGAWSHPQRFSF ratb1’ ....467 .AGTPRHVSVRNQTGDSVSVE W TASQLSTCPGVLT QY VVRCEAEDGAWESEWLVPPTKTQVTLDGLRSRVMYKVQVRADTARLPGAWSHPQRFSF ..

Interleukin-12 RECEPTOR beta-2 chainshumanb2 ...226 .PPWDIRIKFQKASVSRCTLY W RDEGLVLLNRL RY RPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHL.YKGSWSDWSESLRAQTPEEE cowb2 .....226 .PPWDIRIKFVNASVDRCTLL W RDEGLVLLNRL RY RPINSRSWNMVNVTNAKGRHDLLDLKPFTEYEFQISSKLHL.

humanb2 ...421 .LLAPRQVSANSEGMDNILVT W QPPRKDPSAVQ EY VVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIRVYALSGDQGGCSSILGNSKHKA mouseb2 ...436 .LLAPHQVSAKSENMDNILVT W QPPKKADSAVR EY IVEWRALQPGSITKFPPHWLRIPPDNMSALISENIKPYICYEIRVHALSESQGGCS COWb2 .....421 .LLAPQQVLAKSEGMDKLMVT W TPPEKATAAVQ EY VVEWRELHPGAGMQPPLGWLWSPPYRLSALISENIKPYICYEIRVHALAGDQGGCNSTRGNSQHKA ratb2’ ....613 .FLAPHQVSAKSGNMDNIMVT W QPPGKADSVIR EY IVEWRALQQGSVMNLTPHWLRIPPYNMSALISEKIKPYICYEIRVHALSEDQGGCSSIRGDSSHKV

humanb2 ...521 .PLSGPHINAITEEKGSILIS W NSIPVQEQMGCLL HY RIYWKERDSNSQPQLCEIPYRVSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGK mouseb2 ...536 .PVSGPHITAITEKKERLFIS W THIPFPEQRGCIL HY RIYWKERDSTAQPELCEIQYRRSQNSHPISSLQPRVTYVLWMTAVTAAGESPQGNEREF cowb2 .....521 .PLSGPHINAISEEKGSVLIS W DEIPAREQMGCIL HY RIYWKERDSNSQPQLCEIPYRISPNSHPIDSLQPRVTYVLWMTA ratb2’ ....713 .PLSGPHITAITEKKESLFIS W THIPFLEQRGCIL HY RIYWKERHSTAQPELCEIQYRHSQNSHPISSLQPKVTYVLWMTAVTAAGESP

Interleukin-12 beta chainHUMAN .....236 .DPPKNLQLKPLKNSRQVEVS W EYPDTWSTPHS YF SLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS MONKEY ....236 .DPPKNLQLKPLKNSRQVEVS W EYPDTWSTPHS YF SLTFCIQVQGKSKREKKDRIFTDKTSATVICRKNASFSVQAQDRYYSSSWSEWASVPCS MANGABEY ..236 .DPPKNLQLKPLKNSRQVEVS W EYPDTWSTPHS YF SLTFCIQVQGKSKREKKDRIFTDKTSATVICRKNASFSVQAQDRYYSSSWNEWTSVPCS MOUSE .....233 PDPPKNLQMKPLKNS-QVEVS W EYPDSWSTPHS YF SLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSK PIG .......231 PDPPKNLQLNPLKNSRHVEIS W EYPDTWSTPHS YF SLMFGVQVQGKNKREKKDKLFTDQISAKVTCHKDANIRVQARDRYYSSSWSEWASVSCN COW .......236 PDPPKNLQLRPLKNSRQVEVS W EYPDTWSTPHS YF SLTFCVQVQGKNKREKKLFMDQTSAKVTCHKDANVRVQARDRYYSSFWSEWASVSCS DOG .......237 .DPPTNLQLKPLKNSRHVEVS W EYPDTWSTPHS YF SLTFCVQAQGKNNREKKDRLCVDKTSAKVVCHKDAKIRVQARDRYYSSSWSDWASVSCS CAT .......236 .DPPKNLQLKPLKNSRHVEVS W EYPDTWSTPHS YF SLTFGVQVQGKNNREKKDRLSVDKTSAKVVCHKDAKIRVQARDRYYSSSWSNWASVSCS WOODCHUCK .236 .DPPKNLKMKPSKTPQQVEVT W EYPDSWSTPHS YF SLTFSVQVQGKKKKRSNTLHVDKTSVTVTCQKGAKVSVQARDRYYNSSWSEWATMSCP RED DEER ..237 .DPPKNLQLRPLKNSRQVEVS W EYPDTWSTPHS YF SLTFCVQVQGKNKREKKLFMDQTSAKVTCHKDASIRVQARDRYYNSFWSEWASVSCS

Interleukin-21 receptorHUMAN21R ..120 ...PAPPFNVTVTFSGQYNIS W RSDYEDPAFYMLKGKL QY ELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSS MOUSE21R ..120 ...PAPPLNVTVAFSGRYDIS W DSAYDEPSNYVLRGKL QY ELQYRNLRDPYAVRPVTKLISVDSRNVSLLPEEFHKDSSYQLQVRAAPQPGTS

Human sidekick homologs 1 & 2 NP_689957.2/GI:32880201 & NP_061937.2/GI:21735577 hsidekck1 .670 .SPQNLLVSPNSSHSHAVVLS W VRPFDGNSPIL YY IVELSENSSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYS hsidekck2 .216 .APEHPVATLSTVERRAINLT W TKPFDGNSPLI RY ILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFS

hsidekck1 .769 .SAPPKNIVASGRTNQSIMVQ W QPPPETEHNGVLR GY ILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFS hsidekck2 .315 .TAPPQNVIASGRTNQSIMIQ W QPPPESHQNGILK GY IIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS

hsidekck1 .870 .TAPPQNVQTEAVNSTTIQFL W NPPPQQFINGINQ GY KLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS hsidekck2 .416 .TVPPGNVHAEATNSTTIRFT W NAPSPQFINGINQ GY KLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRS

hsidekck1 .972 .PGAVGHLSFTEILDTSLKVS W QEPLEKNGIIT GY QISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSST hsidekck2 .519 .PGPVGHLSFSEILDTSLKVS W QEPGEKNGILT GY RISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVS

hsidekck1 1074 ..SNLVISNISPRSATLQFRP GY DGKTSISR W IVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYS hsidekck2 .620 .PTNLGISNIGPRSVTLQFRP GY DGKTSISR W LVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPS

hsidekck1 1174 .DVAPTSVTVRTASETSLRLR W VPLPDSQYNGNPESV GY RIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGP hsidekck2 .721 .DMAPANVSLRTASETSLWLR W MPLPEMEYNGNPESV GY KIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWS

hsidekck1 1277 .SAAPENVSAEAVSSTQILLT W TSVPEQDQNGLIL GY KILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVP hsidekck2 .824 .SSGPTNVSALATTSSSMLVR W SEVPEADRNGLVL GY KVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPS

hsidekck1 1378 .PGPPVRLVFPEVRLTSVRIV W QPPEEPNGIIL GY QIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPL hsidekck2 .925 .PGPPMGILFPEVRTTSVRLI W QPPAAPNGIIL AY QITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEA

hsidekck1 1479 .PPRELLVPQAEVTARSLRLQ W VPGSDGASPIR YF TMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFS hsidekck2 1026 .PPSRPMVQQEDVRARSVLLS W EPGSDGLSPVR YY TIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEF

hsidekck1 1579 .GEPPGSVSATPHTTSSVLIQ W QPPRDESLNGLLQ GY RIYYRELEYEAGSGTEAKTLKNPIALXAELTAQSSFKTVNSSSTSTMCELTHL hsidekck2 1126 .DEAPTILSVTPHTTTSVLIR W QPPAEDKINGILL GF RIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRM

hsidekck1 1702 .AMAPQNVQVTPLTASQLEVT W DPPPPESQNGNIQ GY KIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDP hsidekck2 1248 .TAAPRNVVVHGATATQLDVT W EPPPLDSQNGDIQ GY KIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPR

hsidekck1 1802 .PGAPSFLAFSEITSTTLNVS W GEPAAANGILQ GY RVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPEL hsidekck2 1348 .PSAPSSVKFSELTTTSVNVS W EAPQFPNGILE GY RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPE

hsidekck1 1902 .SPGSPRDVLVTKSASELTLQ W TEGHSGDTPTT GY VIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNP hsidekck2 1448 .APGPPGVPIIVRYSSAIAIH W SSGDPGKGPIT RY VIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGF

human retina specific protein PAL[Homo sapiens]. NP_056428.1 GI:14149694 rat retina specific glycoprotein; putative type I transmembrane protein NP_647547.1 GI:21326459 similar to retina specific protein PAL [Mus musculus]. XP_138990.1 GI:20873125 human .....428 .ARMVRSVKVVGDTYHSVSLV W KAPQAKNTT AF SVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKTKYVACVCV mouse .....423 .AQMVRSLKVVGDTYHSVSLV W KAPQAGNTT AF SVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKYVACVCVRGLVP rat .......422 .TQMVRSLKVVGDTYHSVSLV W KAPQAGNTT AF SVLYAVFGQRDMRRMTVEAGKTSVTIEGLAPKTKYVACVCVRGLVPT

Neuroglian precursor.Drosophila P20241/GI:14286138 & c.elegans NP_500276.2/GI:25148680 DROME .....614 VPNAPKLTGITCQADKAEIH W EQQGDNRSPIL HY TIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVP C.ELEGANS .611 VPAHPVVETAHCSERKATVK W VAASDHGDSIK KY IVEMFTDFKKNEWEVINEEVNVNKETFEVDITLTPWVNYTFRVVAVNSHGRS

DROME.....714 FKNPDNVVGQGTEPNNLVIS W TPMPEIEHNAPNF HY YVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPL C.ELEGANS .719 YTNPTGVKGEGTEPDNLVIS W KPLDRYYWNAPNM QY LVRYKLDEPIHGWTEFLVEDSLANFTIIRDQPTFRKYLIQ

DROME.....817 DAPTNFTMRQITSSTSGYMA W TPVSEESVRGHFK GY KIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGV C.ELEGANS .832 EAPRDFHIDTQINFTTINFT W NPVDANTVNGHFV GY EIEYWKAENTIRKYSIKIPANSTYKVINSFHAVTNYSAHIRTRNKRLRSAPSD

DROME.....917 PSPVQGLDAYPLGSSAFMLH W KKPLYPNGKLT GY KIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEG C.ELEGANS .921 PGKVHNLRVYSVGSTAILLQ W DAPLQPNGRIR GY FISFQNEKNETEETYVIHRQKHYLHEKSEPDTGYKVSVWAETRAGEGPVT

DROME....1025 PSFSWEQLPSDNGLAKFRIN W LPSTE--GHPGTH FF TMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGP C.ELEGANS 1016 .PDAPIFRVKNISLDSFVVE W QPNNHSVWKMPGA AF FVNYTAESSKTWFQSEIIYLPYTEITIRNLKEDQKYFMQGIAKDGPRRSE

human tripartite motif protein 9isoform 2; homolog of rat RING finger Spring NP_443210.1 GI:16519559 rat tripartite motif protein 9; NP_569104.1 GI:18426848 mouse tripartite motif protein 9 [Mus musculus]. XP_127056.4 GI:28521544 similar to tripartite motif protein 36; human homolog of rat zinc-binding Rbcc728 XP_225947.1 GI:27681771 c.elegans Tripartite motif protein 9 (83.7 kD) NP_503395.1 GI:17558548 similar to tripartite motif protein 9, isoform 1; human homolog of rat RING finger XP_226563.1 GI:27659604

HUMANSIMTRIP36 309 ...PEINEEQSKVYNN-ALID W HHPEK--DKAD SY VLEYRKINRDEEMISWNEIEVHGTSKVVSNLESNSPYAFRVRAYRGSICSPCS HUMANSIMTRP9 ...93 .PVPLLQLEKCCTRNNSATLA W RTPPFTHSPAD GY ILELDDGDGGQFREVYVGKETLCTIDGLHFNSTYNARVK HUMAN TRIP9 ...441 PATPILQLEECCTHNNSATLS W KQPPLSTVPAD GY ILELDDGNGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYS MOUSETRIP9 ....441 PATPILQLEECCTHNNSATLS W KQPPLSTVAAD GY ILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYS RATTRIP9 ......441 PATPILQLEECCTHNNSATLS W KQPPLSTVAAD GY ILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYS C.ELTRIP9. ....499 PSAPIIETSECSAENNSVTVV W RPRNDG-SAVD GF ALEIDTGRDDGNFKEVYSGPDTICTIDGLHFNTVYAARVKSYNS

Cellulomonas fimiExoglucanase A & B precursors(Exocellobiohydrolase A & B) (1,4-beta-cellobiohydrolase A) (CBP95) P50401/GI:1708083 (1,4-beta-cellobiohydrolase B) (CBP120) P50899/GI:1708084

EXOGLUA 478 DTTAPTVPTGLTAGTTTATSVPLS W TASTD---NVAVT GY DVYRGTTLVGTTAATSYTVTGLTPATAYSFTVRAKDAAGNVSAASAAAAATTQSGTVT EXOGLUB 700 DTTAPTVPTGLQAGVVTSTEATIS W TASTD---DTRVT GY DVYRGATKVGTATTTSFTDTGLTASTAYAYTVRAFDAAGNVSAPSAALTVTTKATPS

EXOGLUA 573 DTTAPSVPAGLTAGTTTTTTVPLS W TASTDNAGGSGVA GY EVLRGTTVVGTTTATSYTVTGLTAGTTYSFSVRAKDVAGNTSAASAAVSATTQTGTVV EXOGLUB 794 DTTAPSVPAITSS-SSTANSVTIG W SASTDNAGGSGLA GY DVYRGATRVAQTTALTFTDTGLTASTAYEYTVRARDVAGNVSAPSTAVSVTTKSDTTP

EXOGLUA 671 DTTAPSVPTGLTAGTTTTSSVPLT W TASTDNAGGSGVA GY EVFNGTTRVATVTSTSYTVTGLAADTAYSFTVKAKDVAGNVSAASAAVSARTQAATSGGCT EXOGLUB 891 DTTAPSVPAGLAAMTVTETSVALT W NASTD-TGGSGLK GY DVYRGATRVGSTTTASYTDTGLTAATAYQYTVRATDNAGNVSAASAALS

Streptomyces coelicolor putative secreted beta-mannosidaseNP_733506.1 GI:32141115 Cellulomonas fimi Endoglucanase B precursor (Endo-1,4-beta-glucanase B) (Cellulase) P26225 GI:121813 Cellulomonas fimi Endoglucanase D precursor (Endo-1,4-beta-glucanase) (Cellulase). P50400 GI:1708080 Thermobifida fusca Endoglucanase E-4 precursor (Endo-1,4-beta-glucanase E-4) (Cellulase E4). P26221 GI:2506384

S.COELbMANNASE 364 .PTAPGAPSVTAVTDSSVTLG W VAATDD--TAVS GY DVVLVGDGTSSTVASSTTTTATVTGLTAATTYTFAVHARDAAGNRSARSATVEVT C.FIMI ENDOB ..650 PPTTPGTPVATGVTTVGASLS W AASTD-AGSGVA GY ELYRVQGTTQTLVGTTTAAAYILRDLTPGTAYSYVVKAKDVAGNVSAASAAVTFTT C.FIMI ENDOB ..748 PPTTPGTPVASAVTSTGATLA W APSTGDP--AVS GY DVLRVQGTTTTVVAQTTVPTVTLSGLTPSTAYTYAVRAKNVAGDVSALSAPVTFTT C.FIMI ENDOB ..847 .PTVPGTPVASNVATTGATLT W TASTDSGGSGLA GY EVLRVSGTTQTLVASPTTATVALAGLTPATAYSYVVRAKDGAGNVSAVSSPVTFTT C.FIMI ENDOD ..454 .PTAPTGLRAGTPTASTVPLT W SASTDTGGSGVA GY EVYRGTTLVGTTTATSYTVTGLAADSAYTFSVRAKDGAGNTSAASAAVTARTAAGG C.FIMI ENDOD ..550 .PSVPTGLTAGTPTATSVPLT W TASTDTGGSGVT GY EVYRGSTLVARPTGTSHTVTGLSAATAYTFTVRAVDAAGNVSAASAPVGVTTAPDPTT T.FUSCAENDO-E4 675 PPSAPGSPAVRDVTSTSAVLT W SASSDTGGSGVA GY DVFLRAGTGQEQKVGSTTRTSFTLTGLEPDTTYIAAVVARDNAGNVSQRSTVSFTT

Bacterial ChitinaseStreptomyces coelicolor putative secreted glycosyl hydrolase NP_631079.1 GI:21225300 Streptomyces lividans Chitinase C precursor. P36909 GI:544014 Streptomyces plicatus Chitinase 63 precursor. P11220 GI:116350 Streptomyces olivaceoviridis EXOCHITINASE 1 PRECURSOR. Q05638 GI:544016 Bacillus circulans CHITINASE D PRECURSOR. P27050 GI:6226570 Bacillus circulans Chitinase A1 precursor. P20533 GI:116300

s.coelGlyase ...322 .PTTPANLAFTEPATGQIRLT W NESSDDTAVT GY DVYANGDLLTSVAGDVTTYTDTRPAGTTVTYHVRAKDAAGNQSGDSNSVTRRADT s.coelGlyase ...415 .PTAPSNLALTEPVPGQVKLT W TASTDDRGVT GY DVYADNKLRKSVAGNVTTYTDTQPASANVTYFVRAKDAAGNESGDSNSVFRGGT b.circchitaseA1 465 .PSVPGNARSTGVTANSVTLA W NASTDNVGVT GY NVYNGANLATSVTGTTATISGLTAGTSYTFTIKAKDAAGNLSAASNAVTVSTTAQPGGDTQA b.circchitaseA1 560 .PTAPTNLASTAQTTSSITLS W TASTDNVGVT GY DVYNGTALATTVTGTTATISGLAADTSYTFTVKAKDAAGNVSAASNAVSVKT b.circ chitaseD .92 PPTVPAGLTSSLVTDTSVNLT W NASTDNVGVT GY EVYRNGTLVANTSTTTAVVTGLTAGTTYVFTVKAKDAAGNLSAASTSLSVTTSTG s.olivexo ......169 PPAPPTGLRTGSVTATSVALS W SPVT---GAT GY AVYRDGVKVATASGTSATVTGLTPDTAYAFQVAAVNGAGESAKSATVTATT s.liviChitase-C 142 .PSAPGTPTASNITDTSVKLS W SAATDDKGVK NY DVLRDGAKVATVTGTTYTDNGLTKGTAYSYSVKARDTADQTGPASGAVKVTTTGGG s.plichitase-63 142 .PSAPGTPTASNITDTSVKLS W SAATDDKGVK NY DVLRDGATVATVTGTTYTDNGLTKGTDYSYSVKARDTGDQTGPASGSVKVTTTGGD

Amylopullulanase precursor(Alpha-amylase/pullulanase) T.tfurigenes ...929 .APQAPSNVVVTSGNGKVDLS W LQSD---GAT GY NIYRSSVEGGLYEKIASNVTET-TFEDANVTNGLKYVYAISAIDELGNESGISNDAVAYP T.ethano .......927 .APQPITDLKAVSGNGQVDLS W SAVD---RAV SY NIYRSTVKGGLYEKIASNVTQI-TYIDTDVTNGLKYVYSVTAVDSDGNESALSNEVEAYP T.sacch ........930 .APQVPSNVVATSGNGKVDLS W SQSD---GAT GY NIYRSSVEGGLYEKIASNVTGT-TFEDTNVTNGLKYVYAISAVDELGNESEMSIDTVAYP T.tfuricus .....928 .APQPITDLKAVSGNGKVDLS W SVVD---KAV SY NIYRSTVKGGLYEKIASNVTQI-TYTDTEVTNGLKYVYAVTAVDNDGNESALSNEVEAYP

T.tfurigenes..1158 .KPTAPYLNQPGTESSRVSLT W NPSTDNVGIY DY EIYRSDG--GTFNKIATVSNEVYNYIDTSVINGVTYNYKVVAVDLSFNRTESNVVTIKPD T.ethano ......1159 .PPTALGLQQPGIESSRVTLN W SLSTDNVAIY GY EIYKSLSETGPFVKIATVADTVYNYVDTDVVNGKVYYYKVVAVDTSFNRTASNIVKATP T.sacch .......1158 .KPTAPILNQPGVESSRVSLT W SPSTDNVGIY NY EIYRSDG--GTFNKIATVSNEVYNYVDTSVINGTTYSYKVVAADPSFNRTESNVVTIKPD T.tfuricus ....1164 .TPTAPVLQQPGIESSRVTLN W SPSADDVAIF GY EIYKSSSETGPFIKIATVSDSVYNYVDTDVVNGNVYYYKVVAVDTSYNRTASNTVKATP .V

Chitin Biosynthesis proteinS.cerevisiae ...76 THKPESPVLKIVNVTQTSCVLA W DPLKLGSAKLKSLI LY RKGIRSMVIPNPFKVTTTKISGLSVDTPYEFQLKLITTSGTLWSEKVILRTH S.pombe ........77 QKLPSPPVLKLKNATQTSIVLE W DPLQLSTARLKSLC LY RNNVRVLNISNPMTTHNAKLSGLSLDTEYDFSLVLDTTAGTFPSKHITIKTL Candida ........74 TNLPQPPNLKIKNVTQTSCVLE W DKLNLGTATLKNLI LF KDGKKLGSIPQPLNNRTSKLSGLPIDKSFKVQLRLDTTAGTFLSNEIEVTTH

Roundabout 1,2 & 3 human-1: NP_002932.1/GI:4506569 Zebrafish-2: NP_571556.1/GI:24371280 Drosophila melanogaster-3. AAG41426.1 GI:11907990 human-1 ..561 PSAPSKPEVTDVSRNTVTLS W QPNLNSGAT-PT SY IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISD Zfish-1 ..523 PSAPSKPDVTDVSRTSVSLS W KPNLNAGAT-PT SY VIEAFSHAAGSSWQTLADHVKTESFVLKGLKPSAVYLFLVRAANAYGLSDPS Zfish-2 ..529 PGPPSKPQVTDVTKNSVSLS W QPGLP-GASAIS TY VIEAFSQSVSNSWQTVADHVKTTQYTIKGLRPNTIYLFMVRAVNVQGLSDPSPMSEPV Drome-3 ..519 PSAPGQPKILNATASALTIV W PTSDKAGASSFL GY SVEMYCTNQSRTWIPIASRLSEPIFTVESLTQGAAYMFIVRAENSLGFSPPSPISEPITAGKLVGVR .

human-1 ..675 NAVLHLHNPTVLSSSSIEVH W TVDQQSQYIQ GY KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA Zfish-1 ..637 DVVIHLHNPTILSSSSVRVQ W TVEQQPQYIQ GY KVMYRPSPEGAPQRVDWAMFEVGAPGEHSAVVTQLKKGITYEFKVRPFFNEFQG Zfish-2 ..643 EVIVRLHNPVVLSPTTIQVT W TVDRQSQFIQ GY RVLYRQMSGLSSPGAWQTQDVKVPSERSMVLSALKKGIVYEIKVRPYFNEFQGMDS Drome-3 ..643 NDVVELLEANASDSTTARLS W DIDS-GQYIE GF YLYARELHSSEYKMVTLLNKGQGLSSCTVPGLAKASTYEFFLVPFYKSIVGKPSNSRRMRTLEDVP

human-1 ..778 PPQGVTVSKNDGNGTAILVS W QPPPEDT-QNGMVQ EY KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP Zfish-1 ..741 APRGVTVTGSGDNGTAVLVA W QPPPEEE-QNGVVQ EY KIWCLGNESRYHINRTVDGSTHSVLIPGLVAGVTYRLEVAAGTGAGPGVKS Zfish-2 ..647 PQQVTVLTVGNQNSTSISIS W DPPPAEH-QNGIIQ EY KIWCLGNETRFHVNKTVDAAIRSVVVGGLQAGVQYRVEVAASTSAGVGVKSEP Drome-3 ..741 EAPPYGMEAIQFNRTSVFLK W LPPQPNRTRNGILT SY NVVVKGLDVHNTTRIFKNMTIDAATPTLLLANLTTGVTYYIAV AAATRVGVGP

Rat ROBO4 AAP32918.1 GI:30575795 a.k.a. Magic Roundabout 4 (gi31077126/NP_852040.1) 256 ENVTLLNPEPVKGPKPGPAV W LSWKVSGPAAPAQ SY TALFRAQRDPRDQGSPWTEVLLDGLLNAKLGGLRWGQDYEFKVRPSSGRARGPDSNVLLLRLPEQV 358 PSAPPQEVTLRPGNGSVFVS W APPPAENHNGFIR GY QVWSLGNASLPAANWTVVGEQTQLEIAARMPGSYCVQVAAVTGAGAGEPSIPVCLLLEQAMEQSARD

c.eleganssensory AXon guidance SAX-3, roundabout homolog NP_741748.1 GI:25147920 531 PSSPTQPIIVNVTDTEVELH W NAPSTSGAGPIT GY IIQYYSPDLGQTWFNIPDYVASTEYRIK—-GLKPSHSYMFVIRAENE-KGIGTPS 652 EQLIKLEEVKTINSTAVRLF W KKRKL--EELID GY YIKWRGPPRTNDNQYVNVTSPSTENYVVSNLMPFTNYEFFVIPYHSGVHSIHGAPS

western wild mouse Midline 1 protein. P82457 GI:22653813 383 NPPTIREELCTASYDTITVH W TSDDEFSVV SY ELQYTIFTGQANVVSLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFMVKAINQAGSRSSEPG

Protein-tyrosine phosphatase Delta & Sigma precursorsHuman Delta-GI:1709906; rat Delta-GI:9507011; mouse Delta-GI:20833032; human Sigma- NP_002841.2/gi:19743919; mouse Sigma -NP_035348.1 GI:25092609; rat Sigma- S466217/GI:1085568 hDelta 320 KALPKPPGTPVVTESTATSITLT W DSGNPEPVS YY IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP mDelta .76 ...PKPPGTPVVTESTATSITLT W DSGNPEPVS YY IIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSEQA rDelta 319 ...PKAPGTPVVTENTATSITVT W DSGNPDPVS YY VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP hSigma 317 KSLPKAPGTPMVTENTATSITIT W DSGNPDPVS YY VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAP mSigma 319 ...PKAPGTPVVTENTATSITVT W DSGNPDPVS YY VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA rSigma 319 ...PKAPGTPVVTENTATSITVT W DSGNPDPVS YY VIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQA

hDelta 418 ...SSAPRDVQARMLSSTTILVQ W KEPEEPNGQIQ GY RVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQT mDelta 170 ..PSSAPRDVQARMLSSTTILVQ W KEPEEPNGQIQ GY RVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV rDelta 414 ...ASAPRNVQARMLSATTMIVQ W EEPVEPNGLIR GY RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV hSigma 414 ..PARPPRNVQARMLSATTMIVQ W EEPVEPNGLIR GY RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKT mSigma 413 ..PASAPRNVQARMLSATTMIVQ W EEPVEPNGLIR GY RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV rSigma 413 ..PASAPRNVQARMLSATTMIVQ W EEPVEPNGLIR GY RVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV

hDelta 514 .GVPGQPLNFKAEPESETSILLS W TPPRSDTIA NY ELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQ mDelta 269 ...PGQPLNFKAEPESETSILLS W TPPRSDTIA SY ELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQS rDelta 512 ...PGQPMNLRAEAKSETSIGLS W SAPRQESVI KY ELLFREGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVCQRTLQ hSigma 511 .GVPGQPMNLRAEARSETSITLS W SPPRQESII KY ELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTL mSigma 512 ...PGQPMNLRAEAKSETSIGLS W SAPRQESVI KY ELLFREGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVRQRTLQAK rSigma 512 ...PGQPMNLRAEAKSETSIGLS W SAPRQESVI KY ELLFREGDRGREVGRTFDPTTAFVVEDLKPNTEYAFRLAARSPQGLGAFTAVVCQRTLQ

hDelta 607 SKPSAPPQDISCTSPSSTSILVS W QPPPVEKQNGIIT EY SIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDV rDelta 603 AKPSAPPQDVKCTSLRSTAILI------------------------------------------------LLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDV hSigma 604 SKPSAPPQDVKCVSVRSTAILVS W RPPPPETHNGALV GY SVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDV mSigma 605 ..PSAPPQDVKCTSLRSTAILVS W RPPPPETHNGALV GY SVRYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDV rSigma 603 AKPSAPPQDVKCTSLRSTAILI------------------------------------------------LLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDV

hDelta 711 PSGPPRKVEVEAVNSTSVKVS W RSPVPNKQHGQIR GY QVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGA rDelta 663 PSAPPRKVEAEALNATAIRVL W RSPTPGRQHGQIR GY QVHYVRMEGTEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA hSigma 708 PSAPPRKVEAEALNATAIRVL W RSPAPGRQHGQIR GY QVHYVRMERREARGRRSIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVV mSigma 707 PSAPPRKVEAEALNATAIRVL W RSPTPGRQHGQIR GY QVHYVRMEGAEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA rSigma 664 PSAPPRKVEAEALNATAIRVL W RSPTPGRQHGQIR GY QVHYVRMEGTEARGPPRIKDIMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGA

hDelta 823 .VPGKPRLVINHTQMNTALIQ W HPPVD-TFGPLQ GY RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPE rDelta 766 .VLGRPTLSVQQTPEGSLLAR W EPPADAAEDPVL GY RLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEASAALSIPEDAPR hSigma 811 .VLGRPTLSVQQTPEGSLLAR W EPPAGTAEDQVL GY RLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSPGGLGEEAAEVLSIPE mSigma 810 .VLGRPTLSVQQTPEGSLLAR W EPPADAAEDPVL GY RLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEAAAALSIPEDAPR rSigma 766 .VLGRPTLSVQQTPEGSLLAR W EPPADAAEDPVL GY RLQFGREDAAPATLELAAWERRFAAPAHKGATYVFRLAARGRAGLGEEASAALSIPEDAPR

hDelta 916 EVPTGFPQNLHSEGTTSTSVQLS W QPPVLAERNGIIT KY TLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVD rDelta 872 ...GFPQILGPAGNVSAGSVILR W LPPVPAEGNGAII KY TVSVREAGTPGPATETELAAAAQPGAETALTLQGLRPETAYELRVRAHTRRGPGPFSPPLRYRLARD hSigma 906 TPRGHPQILEAAGNASAGTVLLR W LPPVPAERNGAIV KY TVAVREAGALGPARETELPAGRLSRARRTLTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRT mSigma 906 ...GFPQILGAAGNVSAGSVLLR W LPPVPAERNGAII KY TVSVREAGAPGPATETELAAAAQPGAETALTLRGLRPETAYELRVRAHTRRGPGPFSPP rSigma 862... GFPQILGPAGNVSAGSVILR W LPPVPAEGNGAII KY TVSVREAGTPGPATETELAAAAQPGAETALTLQGLRPETAYELRVRAHTRRGPGPFSPPLRYRLAR

hDelta 1018 ..QVFAKNFHVKAVMKTSVLLS W EIPENYNSAM PF KILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNL rDelta .965 ..PVSPKNFKVKMIMKTSVLLS W EFPDNYNSPT PY KIQYNGLTL—DVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNMLSGKPSVAPKPDNDGSIV mSigma 1009 ..PVSPKNFKVKMIMKTSVLLS W EFPDNYNSPT PY KIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNMLSGK rSigma .965.. PVSPKNFKVKMIMKTSVLLS W EFPDNYNSPT PY KIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTARTAFNMLSGKPSVAPKPDND

PTPases Mu, PCP-2 & KappahMU ....482 .PGAVPTESIQGSTFEEKIFLQ W REPTQTYGVIT LY EITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSM mMu ....482 .PGAVPTESIQGSAFEEKIFLQ W REPTQTYGVIT LY EITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFT hPCP2 ..481 .PSGIAAESLTFTPLEDMIFLK W EEPQEPNGLIT QY EISYQSIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPS hKAPPA .490 .PGPVPVKSLQGTSFENKIFLN W KEPLDPNGIIT QY EISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPT mKappa .489 .PGPVPVKSLQGTSFENKIFLN W KEPLEPNGIIT QY EVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNI

LAR-like PTPasec.elegans-gi:29427539/Q9BMN8; Drosophila-TDFFLK/GI:538578; Anopheles mosquito frag.-S53089/GI:1079024; rat.-S46216/GI:1071964; human-P10586/GI:125978 human 309 .PKPPIDLVVTETTATSVTLT W DSGNSEP-VT YY GIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA rat ..319 .PKPPIDLVVTETTATSVTLT W DSGNTEP-VS FY GIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA D.M. .322 .PTAPTDVQISEVTATSVRLE W SYKGPED-LQ YY VIQYKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGETKM c.el .339 .PPPPVNIVVSSVTSESVVIT W KPPKYNEAIN KY VVNYRLKYSEGRSSRGKTMETLENSLVIDGLVAFQTYEFTVRSAGPVGVGLESLPVEAQTKPSK

human 403 PSSPPRRVQARMLSASTMLVQ W EPPEEPNGLVR GY RVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV rat ..413 PSSPPRRVQARMLSASTMLVQ W EPPEEPNGLVR GY RVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQG D.M. .417 .ESAPRNVQVRTLSSSTMVIT W EPPETPNGQVT GY KVYYTTNSNQPEASWNSQMVDNSELTTVSDVTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGV c.el .436 PATAPVSPQARSLNRDSILVK W GPCEQPNGLIT GY KVYYTNDLVTTPIREWKQHDAKSDEFMTTINGLEPDSRYFVRVIAQNSEGDSPLSTLVTVATRQGI

human 802 .PAQPADFQAEVESDTRIQLS W LLPPQ--ERII MY ELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQST rat ..511 VPAQPADFQAKAESDTRIQLS W LLPPQ--ERII KY ELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEACTAQST D.M. .515 .PSQPSNFRATDIGETAVTLQ W TKPTHSSENIV HY ELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYV c.el .537 IPGQPPMLTVKALDSRRMQLT W DKPLYSSP-VV GY TVRYNTSDGEKELTLTSPHEKHVVTGLHPDKYYYFRVAAYSDRGQGEFTEPMISKTIASIP

human 596 PSAPPQKVMCVSMGSTTVRVS W VPPPADSRNGVIT QY SVAHEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDV rat ..606 PSAPPQKVTCVSTGSTTVRVS W VPPPADSRNGIIT QY SVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDV D.M. .610 PGAPPRNITAIATSSTTISLS W LPPPVERSNGRII YY KVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDV c.el .630 PLSSPTIVSAAATSSKSVEIR W KGPEQKKLNGVLT AY RINYFRLEDSKTANLESVEYDEDMDDSSSFLDRMSVVVPSDATSYVLSDLLPYSSYEITVAASTMDGYGPESSI.

human 698 PSGPPRKVEVEPLNSTAVHVY W KLPVPSKQHGQIR GY QVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSK rat ..708 PSGPPRKVEVEPLNSTAVHVS W KLPVPNKQHGQIR GY QVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGA D.M. .709 .PGDPQDVKATPLNSTSIHVS W KPPLEKDRNGIIR GY HIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVP c.el .750 .PSAPRNFNAELTSATSVKLT W DAPAA--ANGALL GY YVYLDRMVNGEPVVEKGSKKRIVMIRDSSKRYFELDSLDPNTEYSFRLNAFNRNGDGEFSERKSIITQGIP

human 810 .VPGRPTMMISTTAMNTALLQ W HPPKELP--GELL GY RLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDL rat ..811 .VPGRPTMMVSTTAMHTALLQ W HPPKELP--GELL GY RLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDAP D.M. .814 .RPTVSLKIMEREPIVSIELE W ERPAQ--TYGELR GY RLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGT An ....16 .RLAVTLKILELDPTVSIELE W ERPRQ--AYGELR GY RVRWGVREQALNEEILQGTQLAVKRINNLERGVEYEFRVAGMNHIGIGQEAVKHLQTPEGS c.el .858 .PEIVSVSLDRDEPPVVARIE W KMPKMKPNETPIE KY NLWLRAQGYPDSYVKAKTVDGTDLSTTISGLWMGVVYDVLLAAENREGRSQNATETIATPVGS

human 905 PSGFPQNLHVTGLTTSTTELA W DPPVLAERNGRII SY TVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVE rat ..907 .SGFPQNLRVTGLTTSTTELA W DPPVLAERNGRIT NY TVVYRDINSQHELQNVTGDVHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPME D.M. .909 PGGPPSNITIRFQTPDVLCVT W DPPTREHRNGIIT RY DVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGPFSDKLIVETERDM An ...111 PTGPPTGIAVRFQTPDVVCIT W EPPTREHRNGQIT RY DVQFHKKIDHGLGTERNTTVRKAVFTNLDESTEYIVRVRAYTKQGAGPFSEKVVIATERDM c.el .957 .PDGEPIDVQYEVMKGKIVVS W RPPSEEKRNGNIT SY KAILSAMDATADRYEQPV PAPSTSSTFEVNVRRAYLFKVAAATMKGIGPYSPVLTINPDPAAL

human 1002 QVFAKNFRVAAAMKTSVLLS W EVPDSYKSAV PF KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAY rat ..1003 QVFAKNFRVAAAMKTSVLLS W EVPDSYKSAV PF KILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGTSAGGLQHLVSIRTAPDLLPQKPLPASA D.M. .1007 GRAPMSLQAEATSEQTAEIW W EPVTSRGKLL GY KIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIK An ....209 GRAPFSVQAVATSEQTVEVW W EPVPSRGKLV GY KIFYTMTAVEDLDEWQTKVVGVTESADLINLEKFAQYAVAIAAMYKTGLGKLSEKATVKVK c.el .1056 VGPPTNVRVEATSNSTAVVQ W DFE--SQKAD SF VVKYMHEPGNRMDTEKWKQLPVVSIDKENPKRFAVVSDLNAHKPYAFCVLAVKNNLTLNEQFNKVRVTNYMTNF

D.M. .1101 PEDVPLNLRAHDVSTHSMTLS W SPPIRLTPV NY KISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSD YSYRPPTKIT An ....303 PEDVPLNLRAHDVSTHSMTLS W APPIRLNPI NY KISFDAVKEFVDSQGISQKQILPRKEIILKSHVKSHTISELSPFTTYFVNVSAVPTDYSYKPPAK c.el .1178 PTYMVQNLRVLWKTSNSVQLT W EY-NGPRNV GF YVNHTGRKDYVNHELQEKTMSTPGFGQDVDEKHREYLWTNLRPHMMYTIHVGVRTLPPGAR

PTPase BetaHuman- P23467/GI:126469 Mouse- NP_084204.1 /GI:23618914 human .23 EPERCNFTLAESKASSHSVSIQ W RILGSPC NF SLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFKIISLD-EERTVVLQTDP mouse .25 ..VKCNFTLLESRVSSLSASIQ W RTFASPC NF SLIYSSDTSGPMWCHPIRIDNFTYGCNPKDLQAGTVYNFRIVSLDGEESTLVLQTDPL

human 111 .LPPARFGVSKEKTTSTGLHVW W TPSSGKVT SY EVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNG mouse 113 ..PPARFEVNREKTASTTLQVR W TPSSGKVS WY EVQLFDHNNQKIQEVQVQESTTWSQYTFLNLTEGNSYKVAITAVSGEKRSFPVYINGST

human 200 STVPSPVKDIGISTKANSLLIS W SHGSGNVE RY RLMLMDKGILVHGGVVDKHATSYAFHGLSPGYLYNLTVMTEAAGLQNYRWKLVRTA mouse 203 ..VPSPVKDLGISPNPNSLLIS W SRGSGNVE QY RLVLMDKGAIVQDTNVDRRDTSYAFHELTPGHLYNLTIVTMASGLQNSRWKLVRTA

human 290 .PMEVSNLKVTNDGSLTSLKVK W QRPPGNVD SY NITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSCVSGELSAQKMAVGRT mouse 290 .PMEVSNLKVTNDGRLTSLNVK W QKPPGDVD SY SITLSHQGTIKESKTLAPPVTETQFKDLVPGRLYQVTISCISGELSAEKSAAGRTV

human 376 FPDKVANLEANNNGRMRSLVVS W SPPAGDWE QY RILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTV mouse 378 .PEKVRNLVSYNEIWMKSFTVN W TPPAGDWE HY RIVLFNESLVLLNTTVGKEETHYALDGLELIPGRQYEIEVIVESGNLRNSERCQGRTV

human 468 ..PLAVLQLRVKHANETSLSIM W QTPVAEWE KY IISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGDLKNSSSVKGRT mouse 468 ..PLAVLQLRVKHANETSLGIT W RAPLGEWE KY IISLMDRELLVIHKSLSKDAKEFTFTDLMPGRNYKATVTSMSGDLKQSSSIKGRTV

human 553 VPAQVTDLHVANQGMTSSLFTN W TQAQGDVE FY QVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTV mouse 555 .PAQVTDLHVNNQGMTSSLFTN W TKALGDVE FY QVLLIHENVVVKNESVSSDTSRYSFRALKPGSLYSVVVTTVSGGISSRQVVAEGRTV

human 643 .PSSVSGVTVNNSGRNDYLSVS W LVAPGDVD NY EVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTV mouse 644 .PSSVSGVTVNNSGRNDYLSVS W LPAPGEVD HY VVSLSHEGKVDQFLIIAKSVSECSFSSLTPGRLYNVTVTTKSGNYASHSFTEERTV

human 731 .PDKVQGVSVSNSARSDYLRVS W VHATGDFD HY EVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTI mouse 732 .PDKVQGISVSNSARSDYLKVS W VHATGDFD HY EVTIKNRESFIQTKTIPKSENECEFIELVPGRLYSVTVSTKSGQYEASEQGTGRTI

human 819 ..PEPVKDLTLRNRSTEDLHVT W SGANGDVD QY EIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTV mouse 820 ..PEPVKDLTLLNRSTEDLHVT W SRANGDVD QY EVQLLFNDMKVFPHIHLVNTATEYKFTALTPGRHYKILVLTISGDVQQSAFIEGLPV

human 907 .PSAVKNIHISPNGATDSLTVN W TPGGGDVD SY TVSAFRHSQKVDSQTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTV mouse 908 .PSTVKNIHISANGATDRLMVT W SPGGGDVD SY VVSAFRQDEKVDSQTIPKHASEHTFHRLEAGAKYRIAIVSVSGSLRNQIDALGQTV

human 995 .PASVQGVIADNAYSSYSLIVS W QKAAGVAE RY DILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEGRTV mouse 996 .PASVQGVVAANAYSSNSLTVS W QKALGVAE RY DILLLNENGLLLSNVSEPATARQHKFEDLTPGKKYKMQILTVSGGLFSKESQAEGRTV

human 1085 .PAAVTDLRITENSTRHLSFR W TASEGELS WY NIFLYNPDGNLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFG mouse 1086 .PAAVTNLRITENSSRYLSFG W TASEGELS WY NIFLYNPDRTLQERAQVDPLVQSFSFQNLLQGRMYKMVIVTHSGELSNESFIFGRTV

human 1170 RTVPASVSHLRGSNRNTTDSL W FNWSPASG DF DFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA mouse 1174 PAAVNHLKGSHRNTTDSLWFS W SPASGDFD FY ELILYNPNGTKKENWKEKDVTEWRFQGLVPGRKYTLYVVTHSGDLSNKVTGEGRTA

human 1261 .PSPPSLMSFADIANTSLAIT W KGPPDWTDYN DF ELQWLPRDALTVFNPYNNRKSEGRIVYGLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTK mouse 1262 .PSPPSLLSFADVANTSLAIT W KGPPDWTDYN DF ELQWFPGDALTIFNPYSSRKSEGRIVYGLHPGRSYQFSVKTVSGDSWKTYSKPISGSVRTK human 1355 .PDKIQNLHCRPQNSTAIACS W IPPDSDFD GY SIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDSTITMIDRPPPPPP mouse 1356 .PDKIQNLHCRPQNSTAIACS W IPPDSDFD GY SIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVED

Tumor suppressor protein DCC precursors.Mouse-P70211/GI:2497302; human-P43146/GI:1169233 human .429 .PSAPRDVVPVLVSSRFVRLS W RPPAEAKGNIQ TF TVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ mouse .429 .PSAPRDVLPVLVSSRFVRLS W RPPAEAKGNIQ TF TVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQ

human .528 .PGPVENLQAVSTSPTSILIT W EPPAYANGPVQ GY RLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVP mouse .528 .PGPVENLHAVSTSPTSILIT W EPPAYANGPVQ GY RLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVP

human .623 .SAPPQNVSLEVVNSRSIKVS W LPPPSGTQN GF ITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQ mouse .623 .SAPPQNISLEVVNSRSIKVS W LPPPSGTQN GF ITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQ

human .725 .VPDQPSSLHVRPQTNCIIMS W TPPLNPNIVVR GY IIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDP mouse .725 .VPDQPSSLHVRPQTNCIIMS W TPPLNPNIVVR GY IIGYGVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRS

human .843 PMLPPVGVQAVALTHDAVRVS W ADNSVPKNQKTSEVR LY TVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTY mouse .843 PMLPPVGVQAVALTHEAVRVS W ADNSVPKNQKTSDVR LY TVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTY

human .946 SAPKDFTVITREGKPRAVIVS W QPPLEANGKIT AY ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFR mouse .946 SAPKDLTVITREGKPRAVIVS W QPPLEANGKIT AY ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFR

Down syndrome cell adhesion molecule (human & rat)hDSCam 885 PPDPPEIEIKDVKARTITLR W TMGFDGNSPIT GY DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAP rDSCam 885 PPDPPEIEIKDVKARTITLR W TMGFDGNSPIT GY DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEITITADEAAP

hDSCam 985 DGPPQEVHLEPISSQSIRVT W KAPKKHLQNGIIR GY QIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP rDSCam 985 DGPPQEVHLEPTSSQSIRVT W KAPKKHLQNGIIR GY QIGYREYSTGGNFQFNIISIDTTGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP

hDSCam 1089 SYPPENVQAIATSPESISIS W STLSKEALNGILQ GF RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV rDSCam 1089 SYPPENVQAIATSPESISIS W STLSKEALNGILQ GF RVIYWANLIDGELGEIKNVTTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV

hDSCam 1189 PGPPAGVKAAAASASMVFVS W LPPLKLNGIIR KY TVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILT rDSCam 1189 PGPPAGVKAAAASASMVFVS W LPPLKLNGIIR KY TVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILT

hDSCam 1379 PPDQPRLTVSKTTSSSITLS W LPGDNGGSSIR GY ILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE rDSCam 1379 PPDQPRLTVSKTTSSSITLS W LPGDNGGSSIR GY ILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE

Human putative neuronal cell adhesion moleculeNP_004875.1 GI:30911097 427 PRNVRAVSVSSTEVRVS W SEPLANTKEII GY VLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPTLASTLGEAPA 524 PPPLSVRVLGSSSLQLL W EPWPRLAQHEG GF KLFYRPASKTSFTGPILLPGTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNAT.

Neural cell adhesion molecule L1 precursor(N-CAM L1) (CD171antigen). P32004 GI:1705571 L1 CAM ADhesion molecule homolog (lad-1) [Caenorhabditis elegans]. NP_501349.1 GI:17538700 rat neural cell adhesion molecule L1 [Rattus norvegicus]. NP_059041.1 GI:8393820 hNCAML1 ..615 VPRLVLSDLHLLTQSQVRVS W SPAEDHNAPIE KY DIEFEDKEMAPEKWYSLGKVPG NQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAP mNCAML1 ..614 VPHLELSDRHLLKQSQVHLS W SPAEDHNSPIE KY DIEFEDKEMAPEKWFSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSESVVTPEAAP rNCAML1 ..614 VPHLELSDRHLLKQSQVHLS W SPAEDHNSPIE KY DIEFEDKEMAPEKWFSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAA

hNCAML1 ..715 EKNPVDVKGEGNETTNMVIT W KPLRWMDWNAPQV QY RVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYP mNCAML1 ..714 EKNPVDVRGEGNETNNMVIT W KPLRWMDWNAPQI QY RVQWRPQGKQETWRKQTVSDPFLVVSNTSTFVPYEIKVQAVNNQGKGPEPQVTIGYSGEDYP rNCAML1 ..714 EKNPVDVRGEGNETNNMVIT W KPLRWMDWNAPQI QY RVQWRPLGKQETWKEQTVSDPFLVVSNTSTFVPYEIKVQAVNNQGKGPEPQVTIGYSGEDY c.elegans 712 DKNPDEVAAKGTSPENIIVQ W KPMSREEWNGADF HY VVKYRPKDEDQRVGDWKEVAVEDPFADRVTVNLDDEKDVKPFQPYEVQVQAVNSEGRT

hNCAML1 ..813 QAIPELEGIEILNSSAVLVK W RPVDLAQVKGHLR GY NVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFST mNCAML1 ..812 QVSPELEDITIFNSSTVLVR W RPVDLAQVKGHLK GY NVTYWWKGSQRKHSKRHIHKSHIVVPANTTSAILSGLRPYSSYHVEVQAFNGRGLGPASEWTFSTP rNCAML1 ..812 QVSPELEDITIFNSSTVLVR W RPVDLAQVKGHLR GY NVTYWWKGSQRKHSKRHVHKSHMVVPANTTSAILSGLRPYSSYHVEVQAFNGRGLGPASEWTF c.elegans 822 SSIPSGLRVLEKSGTTVTLA W NGVDPQTANGNFT GY KITYWVDEADQDSDDSSEDDEDDEKRKFRWKRSIRVKRQSGIRKTVVFGPSATQGTLTDLKPA

hNCAML1 ..918 PGHPEALHLECQSNTSLLLR W QPPLSHNGVLT GY VLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALS mNCAML1 ..917 PGHPEALHLECQSDTSLLLH W QPPLSHNGVLT GY LLSYHPVEGESKEQLFFNLSDPELRTHNLTNLNPDLQYRFQLQATTQQGGPGEAIVREGGTMALF rNCAML1 ..917 PGHPEALHLECQSDTSLLLH W QPPLSHNGVLT GY LLSYHPLDGESKEQLFFNLSDPELRTHNLTNLNPDLQYRFQLQATTHQGPGEAIVREGGTMALFGK c.elegans 957 LRAYPMNSKVGGEKGVVVLV W KKPRQTNGKLA RY EVEYCKTQNGKLVEKSCPRKQIDADSKEIRITGLENETPYRFILRAHTSAGEGDPN

hNCAML1 .1016 GISDFGNISATAGENYSVVS W VPKEGQCNF RF HILFKALGEEKGGASLSPQYVSYNQSSYTQWDLQPDTDYEIHLFKERMFRHQMAVKTNGTGRV mNCAML1 .1016 GKPDFGNISATAGENYSVVS W VPRKGQCNF RF HILFKALPEGKVSPDHQPQPQYVSYNQSSYTQWNLQPDTKYEIHLIKEKVLLHHLDVKTNGTG

c.elegansJuxtamembrane domain-Associated Catenin JAC-1NP_502910.1 GI:17541130 C.EL JAC1 240.PLAPGRPTVIAVDGQGVLLE W TPPVADVHSSPPQ GY QVEYRVYGSRD- W IVANEQLVQENVFTVESLRPNGVYEFRVRGKNQDGLGHPS C.EL JAC1 455 PNILEAPEFLEVDGDKITIC W LPAQ---SQLPVM GY DVEFRDLQQDDR W YKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNASGCSQPS

Nephrin precursor (Renal glomerulus-specific cell adhesion receptor). mouse Q9QZS7/GI:20178015; Human: O60500/GI:20177993; Rat: Q9R044/GI:20177992 human ....941 PDPPSGLKVVSLTPHSVGLE W KPGFDGGLPQ RF CIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLA mouse ....941 PDPPLGLKVVSVSPHSVGLE W KPGFDGGLPQ RF QIRYEALETPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLT rat ......937 PDPPLGLKVVSISPHSVGLE W KPGFDGGLPQ RF QIRYEALETPGFLHVDVLPTQATTFTLTGLKPSTRYRIWLLASNALGDSGLT..D

Myosin-binding Protein C(cardiac and skeletal muscle) HUMAN MYBCC .772 PDAPAAPKISNVGEDSCTVQ W EPPAYDGGQPIL GY ILERKKKKSYR W MQLNFDLIQELSHEARRMIEGVVYEMRVYAVNAIGMSRPSPASQPFMPIGP MOUSE MYBCC .768 PDAPAAPKISNVGEDSCTVQ W EPPAYDGGQPVL GY ILERKKKKSYR W MRLNFDLLRELSHEARRMIEGVAYEMRVYAVNAVGMSRPSPASQPFMPIGP CHICK MYBCC .770 PDPPEAPKISNIGEDYCTVQ W QPPTYDGGQPVL GY ILERKKKKSYR W MRLNFDLLKELTYEAKRMIEGVVYEMRIYAVNSIGMSRPSPASQPFMPIAP HUMAN MYBCS .620 PDPPVAPTVTEVGDDWCIMN W EPPAYDGGSPIL GY FIERKKKQSSR W MRLNFDLCKETTFEPKKMIEGVAYEVRIFAVNAIGISKPSMPSRPFVPLAV MOUSE MYBC’ .307 PDAPAAPKISNVGEDSCTVQ W EPPAYDGGQPVL GY ILERKKKKSYR W MRLNFDLLRELSHEARRMIEGVAYEMRVYAVNAVGMSRPSPASQPFMPIGP MOUSE MYBCF .634 PDPPEAVRVTSVGENWAILV W EPPKYDGGQPVT GY LMERKKKGSQR W MKINFEVFTDTTYESTKMIEGVLYEMRVFAVNAIGVSQPSMNTKPFMPIAP CHICK MYBC ..631 PDPPQSVRVTSVGEDWAVLS W EAPPFDGGMPIT GY LMERKKKGSMR W MKLNFEVFPDTTYESTKMIEGVFYEMRVFAVNAIGVSQPSLNTQPFMPIAP

HUMAN MYBCC .870 PSEPTHLAVEDVSDTTVSLK W RPPERVGAGGLD GY SVEYCPEGCSE W VAALQGLTEHTSILVKDLPTGARLLFRVRAHNMAGPGAPVTTTE MOUSE MYBCC .866 PGEPTHLAVEDVSDTTVSLK W RPPERVGAGGLD GY SVEYCQEGCSE W TPALQGLTERRSMLVKDLPTGARLLFRVRAHNVAGPGGPIVTKEPVTV CHICK MYBCC .868 PSEPTHFTVEDVSDTTVALK W RPPERIGAGGLD GY IVEYCKDGSAE W TPALPGLTERTSALIKDLVTGDKLYFRVKAINLAGESGAAIIKEPV HUMAN MYBCS .718 TSPPTLLTVDSVTDTTVTMR W RPPDHIGAAGLD GY VLEYCFEGTED W IVANKDLIDKTKFTITGLPTDAKIFVRVKAVNAAGASEPKYYSQPI MOUSE MYBC’ .405 PGEPTHLAVEDVSDTTVSLK W RPPERVGAGGLD GY SVEYCQEGCSE W TPALQGLTERTSMLVKDLPTGARLLFRVR MOUSE MYBCF .732 TSAPQHLTVEDVTDTTTTLK W RPPDRIGAGGID GY LVEYCLEGSEE W VPANKEPVERCGFTVKDLPTGARILFRVVGVNIAGRSEPATLLQPVTIREI CHICK MYBC ..729 TSEPTHVVLEDVTDTTATIK W RPPERIGAGGVD GY LVEWCREGSNE W VAANTELVERCGLTA RGLPTGERLLFRVISVNMAGKSPPATMAQP

HUMAN MYBCC 1066 PSPPQDLRVTDAWGLNVALE W KPPQDVGNTELW GY TVQKADKKTME W FTVLEHYRRTHCVVPELIIGNGYYFRVFSQNMVGFSDRAATTKEPVFI MOUSE MYBCC 1062 PSPPQDIRIVETWGFNVALE W KPPQDDGNTEIW GY TVQKADKKTME W FTVLEHYRRTHCVVSELIIGNGYYFRVFSHNMVGSSDKAAATKEPVFIPRP CHICK MYBCC 1064 PGPPQNIKLADVWGFNVALE W TPPQDDGNAQIL GY TVQKADKKTME W YTVYDHYRRTNCVVSDLIMGNEYFFRVFSE HUMAN MYBCS .914 PGPPQIVKIEDVWGENVALT W TPPKDDGNAAIT GY TIQKADKKSME W FTVIEHYHRTSATITELVIGNEYYFRVFSENMCGLSEDATMTKESAVIAR MOUSE MYBC’ .601 PSPPQDIRIVETWGFNVALE W KPPQDDGNTEIW GY TVQKADKKTME W FTVLEHYRRTHCVVSELIIGNGYYFRVFSHNMVGSSDKAAATKEPVFIPRP MOUSE MYBCF .928 AGPAENVMVKEVWGTNALVE W QPPKDDGNSEIT GY FVQKADKKTME W FNVYEHNRHTSCTVSDLIVGNEYYFRIFSENICGLSDSPGVSKNTA CHICK MYBC ..924 PGPPQAVRVMEVWGSNALLQ W EPPKDDGNAEIS GY TVQKADTRTME W FTVLEHSRPTRCTVSELVMGNEYRFRVYSENVCGTSQEPATSHNTARIAK

Myosin Binding Protein H HUMAN MYBH . .71 PSAPLLLTLDDVSSSSVTVS W EPPERLGRLGLQ GY VLELCREGASE W VPVSARPMMVTQQTVRNLALGDKFLLRVSAVSSAGAGPPAMLDQPIHIRENIE MOUSE MYBH . .77 PSAPLRLTLEDVSHSSLTVS W EPPEKLGKLGLQ GY VLEFCREGASE W VPVNPRPVMVTQQTVRNLALGDKFFLRVTAVSSAGAGPPAVLDQPVH RAT ..MYBH . .78 PSAPLQLTLEDVSHSSLTVS W EPPEDLGSWGSR AM CWSSVREGASE W VPVNPRPVMVTQQTVRNLALGDKFFLRVTAVNSAGAGPPAVLDQPV CHICK MYBH ..135 PSVPLSLAVEEVTENSVTLT W KAPEHTGKSSLD GY VVEICKDGSTD W TAVNKEPFLSTRYKIHDLASGEKVHVRVKAISASGTSDPATLEQPVLIR

HUMAN MYBH ..267 PGPPSSIRLLDVWGCNAALQ W TPPQDTGNTELL GY MVQKADKKTGQ W FTVLERYHPTTCTISDLIIGNSYSFRVFSENLCGLSTSATVTKELAH MOUSE MYBH ..273 PGPPSSIKLLDVWGCNAALE W TPPQDTGNTELL GY TVQKADKRTGQ W FTVLERYHPTTCTISDLIIGNSYSFRVFSENLCGLSDLATTTKELAHIHKA RAT ..MYBH ..274 PGPPSSIKLLDVWGCNAALE W MPPQDTGNTELL GY TVQKADKKTGQ W FTVLERYHPTTCTVSDLIIGNSYSFRVFSENLCGLSDLAT CHICK MYBH ..331 PGPPQNLKLVDVWGFNVALE W SPPADNGNSEIK GY TVQKSDKKSGK W FTVLERCTRTSCTISDLIIGNTYSFRVFSENACGMSETAAVAA

Collagen Isoforms

RAT Collagen alpha-1 (III) 477 PMTVPRKHWWTDAGAEKKHV W FGESMNG GF QFSYGNPDLPEDVLDVQLAFLRLLSSRASQNITYHCKNSIAYMDQANGNVKKSL

Collagen alpha-1 (VII)HUMAN a1(VII) .232 TSAPRDLVLSEPSSQSLRVQ W TAASGPVT GY KVQYTPLTGLGQPLPSERQEVNVPAGETSVRLRGLRPLTEYQVTVIALYANSIGEAVSGTARTT MOUSE a1(VII) .233 PSGPRDLVLSEPSSQSLRVQ W TAASGPVT GY KVQYTPLTGLGQPLPSERQEVNIPAGETSTRLQGLRPLTDYQVTVVALYANSIGEAVSGTARTT

HUMAN a1(VII) .327 ALEGPELTIQNTTAHSLLVA W RSVPGAT GY RVTWRVLSGGPTQQQELGPGQGSVLLRDLEPGTDYEVTVSTLFGRSVGPATSLMARTD MOUSE a1(VII) .328 AKEGLELSLQNITSHSLLVA W RRVPGAN GY RVTWRDLSGGPTQQQDLSPGQGSVFLDHLEPGTDYEVTVSALFGHSVGPAASLTARTA

HUMAN a1(VII) .415 ASVEQTLRPVILGPTSILLS W NLVPEAR GY RLEWRRETGLEPPQKVVLPSDVTRYQLDGLQPGTEYRLTLYTLLEGHEVATPATVVPTGPELP MOUSE a1(VII) .416 SSVEQTLHPIILSPTSILLS W NLVPEAR GY RLEWRRESGLETPQKVELPPDVTRHQLDGLQPGTEYRLTLYTLLEGREVATPATVVPTGLEQL

HUMAN a1(VII) .508 VSPVTDLQATELPGQRVRVS W SPVPGAT QY RIIVRSTQGVERTLVLPGSQTAFDLDDVQAGLSYTVRVSARVGPREGSASVLTVRREPET MOUSE a1(VII) .509 VSPVMNLQAIELPGQRVRVS W NPVPGAT EY RFTVRTTQGVERTLLLPGSQTTFDLDDVRAGLSYTVRVSARVGAQEGDASILTIHRDPEA

HUMAN a1(VII) .598 PLAVPGLRVVVSDATRVRVA W GPVPGAS GF RISWSTGSGPESSQTLPPDSTATDITGLQPGTTYQVAVSVLRGREEGPAAVIVARTDP MOUSE a1(VII) .599 PLVVPGLRVVASDATRIRVA W GLVPGAS GF RISWRTGSGPESSRTLTPDSTVTDILGLQPGTSYQVAVSALRGREEGPPVVIVARTDP HUMAN a1(VII) .685 LGPVRTVHVTQASSSSVTIT W TRVPGAT GY RVSWHSAHGPEKSQLVSGEATVAELDGLEPDTEYTVHVRAHVAGVDGPPASVVVRTAPEP MOUSE a1(VII) .687 LGPVRRVHLTQAGSSSVSIT W TGVPGAT GY RVSWHSGHGPEKSLLVSGDATVAEIDGLEPDTEYIVRVRTHVAGVDGAPASVVVRTAPEP

HUMAN a1(VII) .776 VGRVSRLQILNASSDVLRIT W VGVTGAT AY RLAWGRSEGGPMRHQILPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPVSIVVTTPPEA MOUSE a1(VII) .777 VGSVSKLQILNASSDVLRVT W VGVPGAT SY KLAW GRSEGGPMKHRILPGNKESAEIRDLEGGVSYSVRVTALVGDREGAPVSIVITTPPAT.

HUMAN a1(VII) .867 PPALGTLHVVQRGEHSLRLR W EPVPRAQ GF LLHWQPEGGQEQSRVLGPELSSYHLDGLEPATQYRVRLSVLGPAGEGPSAEVTARTESP MOUSE a1(VII) .868 PALLETLQVVQSGEHSLRLR W EPVPGAP GF RLHWQPEGGQEQSLTLGPESNSYNLVGLEPATKYQVWLTVLGQTGEGPPRKVTAYTEPS

HUMAN a1(VII) .956 RVPSIELRVVDTSIDSVTLA W TPVSRAS SY ILSWRPLRGPGQEVPGSPQTLPGISSSQRVTGLEPGVSYIFSLTPVLDGVRGPEA MOUSE a1(VII) .957 HIPSTELRVVDTSIDSVTLT W TPVSGAS SY ILSWRPLRGTGQEVPRAPQTLPGTSSSHRVTGLEPGISYVFSLTPIQSGVRGSEISVTQTPACS

Collagen a1(XII)HUMAN a1(XII) ..25 VDPPSDLNFKIIDENTVHMS W AEPVDPIV GY RITVDPTTDGPTKEFTLSASTTETLLSELVPETEYVVTITSYDEVEESVPVIGQLTIQT MOUSE a1(XII) ..25 VDPPSDLNFKIIDENTVHMS W ERPVDPIV GY RITVDPTTDGPTKEFTLAASTTETLLSDLIPETQYVVTITSYNEVEESVPVIGQLTIQT CHICK a1(XII) ..25 VNPPSDLNFTIIDEHNVQMS W KRPPDAIV GY RITVVPTNDGPTKEFTLSPSTTQTVLSDLIPEIEYVVSIASYDEVEESLPVFGQLTIQTGGPGIP

HUMAN a1(XII) .334 VEPPSNLIAMEVSSKYVKLN W NPSPSPVT GY KVILTPMTAGSRQHALSVGPQTTTLSVRDLSADTEYQISVSAMKGMTSSEPISIME MOUSE a1(XII) .334 IEPPSNLVVTELSSKYIRLS W DPSPSAVT GY KILLTPMAAGSRHHALSVGPQTTTLNVRDLTADTEYQISVFAMKGLTSSEPTSVMEKTQ CHICK a1(XII) .333 VEPASNLVATQISSKSVRIT W DPSTSQIT GY RVQFIPMIAGGKQHVLSVGPQTTALNVKDLSPDTEYQINVYAMKGLTPSEPITIMEKTQQVKVQVEC

HUMAN a1(XII) .632 YVPPKDLSFSEVTSYGFKTN W SPAGENVF SY HITYKEAAGDDEVTVVEPASSTSVVLSSLKPETLYLVNVTAEYEDGFSIPLAGEETTEEV MOUSE a1(XII) .636 YVPPKDLRFTQVTANSFKAE W SPPGDNVF SY HVTYKDANGDDEVTVVEPASSTSVVLNSLRPETLYLVNVTAEYEDGFSVPITGEETTAEV NEWT a1(XII) ...65 LTPPRDLSFAEVTSSSFRVS W SPAAEDAI AY LVNYTVALGGEEFVVSVPAPTTSTVLTNLFPKTTYEVRVVAEYPEGESPPLKGEETTLEV CHICK a1(XII). 631 YVPAKNMVFSDVTSDSFKVS W SAAGSEEK SY LIKYKVAIGGDEFIVSVPASSTSSVLTNLLPETTYAVSVIAEYEDGDGPPLDGEETTLEV

HUMAN a1(XII) .723 KGAPRNLKVTDETTDSFKIT W TQAPGRVL RC RIIYRPVAGGESREVTTPPNQRRRTLENLIPDTKYEVSVIPEYFSGPGTPLTGNAATEEV MOUSE a1(XII) .727 KGVPRNLKVTDETTDSFKLT W SQAPGRVL RY RIRYRPVSGGESKEVSTPANQRRKTLENLTPDTKYEISVIAEYPSGPGSPLTGNAATEEV NEWT a1(XII) ..156 RGAPRNLRVTDETTDSFKVG W TPAPGNVL RY RIAYRPVAGGERKEVTVQGNERATTLYNLFPDTKYHVSGVPEYQSGPGTALNGNGATEEVV CHICK a1(XII) .722 KGAPRNLRITDETTDSFIVG W TPAPGNVL RY RLVYRPLTGGERRQVTVSANERSTTLRNLIPDTRYEVSVIAEYQSGPGNALNGYAKTDEVR

HUMAN a1(XII) .814 RGNPRDLRVSDPTTSTMKLS W SGAPGKVK QY LVTYTP-VAGGETQEVTVRGDTTNTVLQGLKEGTQYALSVTALYASGAGDALFGEGTTLEE MOUSE a1(XII) .818 RGNPRDLRVSDATTSTLKLS W SRAPGKVK QY LVTYTP-AAGGETQEVTVRGDTTTTMLRKLKEGTQYDLSVTALYASGAGEALSGKGSTLEE NEWT a1(XII) ..248 GEPKNLRVSEPTTSTAMRLT W DKAPGKVQ RY LRNLHSRSAGGDIKEVTVKGDTSTTVLKELDPGTAYTLSVNPLYASGAGTAVTGEGATLQE CHICK a1(XII) .814 GNPRNLRVSDATTSTTMKLS W SAAPGKVQ HV LYNLHTRYAGVETKELTVKGDTTSKELKGLDEATRYALTVSALYASGAGEALSGEGETLEE

HUMAN a1(XII) .905 RGSPQDLVTKDITDTSIGAY W TSAPGMVR GY RVSWKSLYDDVDTGEKNLPEDAIHTMIENLQPETKYRISVFATYSSGEGEPLTGDATTEL MOUSE a1(XII) .909 RGSPQNLVTKDITDTSIGAY W TSAPGMVR GY RVSWKSLYDDIEAGETTLNGDAIHTMIENLQPETKYKISVFATYSSGEGEPVTGDATTEL NEWT a1(XII) ..340 RGSPRDLIIKDITDTTIGTS W TAAPGMVR GY RIAWQSLFDDKTGENHVPGDTTNTVLRNLDPETKYRLSVYANYASGEGDPLSGEATTEA CHICK a1(XII) .906 RGSPRNLITTDITDTTVGLS W TPAPGTVN NY RIVWKSLYDDTMGEKRVPGNTVDAVLDGLEPETKYRISIYAAYSSGEGDPVEGEAFTDVSQSAR

HUMAN a1(XII) .996 SQDSKTLKVDEETENTMRVT W KPAP-GKVV NY RVVYRPHGRGKQMVAKVPPTVTSTVLKRLQPQTTYDITVLPIYKMGEGKLRQGSGTTASR MOUSE a1(XII) 1000 SQDSKILRVDEETEHTMRVT W KAAP-GKVV NY RVVYRPQGGGRQMVAKVPPTVTSTVLKRLQPQTTYDITVLPMYKTGEGKLRQRSGTTASR NEWT a1(XII) ..430 SPDGKIVKISEETETTMKAT W QPAP-GNVL NY RVVYRPRAGGRQIVAKVPPAVTSTVLRRLTPLTTYDISVIPVYKEGDGKTRQGSGTTLSP CHICK a1(XII) 1001 TVTVDNETENTMRVSVAALT W EGLVLARVL PN RSGGRQMFGKVNASATSIVLKRLKPRTTYDLSVVPIYDFGQGKSRKAEGTTASP

HUMAN a1(XII) 1087 FKSPRNLKTSDPTMSSFRVT W EPAPGEVK GY KVTFHPTGDDRRLGELVVGPYDNTVVLEELRAGTTYKVNVFGMFDGGESSPLVGQEMTTLSDTTVMPILSSGM MOUSE a1(XII) 1091 FKSPRNLKTSDPTMSSFRVT W EPAPGEVK GY KVTFHPTGDDRRLGELVLGPYDNTVVLEELRAGTTYRVNVFGMFDGGESLPLVGQEMTTLS NEWT a1(XII)...521 FNAPRSIKTSEPTRSTFRVT W EPAPGEVK GY KITFHPEGDDGYLGEMMVGPYDSTVVLEELRARTSYKVNVFGVFDDGQS CHICK a1(XII) 1087 FKPPRNLRTSDSTMSSFRVT W EPAPGRVK GY KVTFHPTEDDRNLGELVVGPYDSTVVLEELRAGTTYKVNVFGMFDGGESNPLVGQEMTTLSDT

HUMAN a1(XII) 1385 LEAPSNLVISERTHRSFRVS W TPPSDSVD RY KVEYYPVSGGKRQEFYVSRMETSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTL MOUSE a1(XII) 1389 LEAPTNLVISERTHRSFRVS W TPPSDSVD RY KVEYYPVSGGKRQEFYVSRLDTSTVLKDLKPETDYVVNVYSVVEDEYSEPLKGTEKAL RABBIT a1(XII).128 LEAPSNLVISERTHRSFRVS W TPPSDSVD RY KVEYYPVSGGKRQEFYVSRLETSTVLKDLKPETEYVVNVYSVVEDEYSEPLKGTEKTL NEWT a1(XII) ..819 LNPPSNLVTSEPTPRSFRVT W VPPSQSVE RF KVEYYPVAGGRPQEVYVRGTQTTTVLVGLKPETEYYVNVYSVEGNEISEPLAGTETTLPIP CHICK a1(XII) 1385 LPPPSNLVISEVTPHSFRLR W SPPPESVD RY RVEYYPTTGGPPKQFYVSRMETTTVLKDLTPETEYIVNVFSVVEDESSEPLIGREITYP

HUMAN a1(XII) 1474 PVPVVSLNIYDVGPTTMHVQ W QPV-GGAT GY ILSYKPVKDTEPTRPKEVRLGPTVNDMQLTDLVPNTEYAVTVQAVLHDLTSEPVTVREVTLP MOUSE a1(XII) 1478 PVPVVSLNIYDVGPTTMHVQ W QPV-GGAT GY TVSYQPTRSPEGTKPKEMRVEPTVNDVQLTGLLPNTEYEVTVQAVLYDLTSEPAKAREVTLP RABBIT a1(XII) 217 PVPIVSLNIYDIGPTTMRVQ W QPV-GGAT GY TVSYEPVKTTESTKPKEMRVGPTVNDVQLTDLLPSTEYEVTVQAVLHDLTSEPATAREMTLP CHICK a1(XII) 1475 LSSVRNLNVYDIGSTSMRVR W EPV-NGAT GY LLTYEPVNATVPTTEKEMRVGPSVNEVQLVDLIPNTEYTLTAYVLYGDITSDPLTSQEVTLP

HUMAN a1(XII) 1566 LPRPQDLKLRDVTHSTMNVF W EPVPGKVR KY IVRYKTPEEDVKEVEVDRSETSTSLKDLFSQTLYTVSVSAVHDEGESPPVTAQETTRP MOUSE a1(XII) 1570 LPRPQDVKLRDVTHSTMNVV W EPVLGKVR KY IVRYKTPDEEFKEVEVDRSRASTILKDLSSQTQYTVSVSAVYDEGTSPPATAYDTTRR RABBIT a1(XII) 309 LPRPQDVKLRDVTHSTMSVF W EPVLGKVR KY VVRYQTPEEDVKEVEVDRSRTSTSLKDLLSQTLYTVSVSAVYDEGESPPVTAQETTRP CHICK a1(XII) 1567 LPGPRGVTIRDVTHSTMNVL W DPAPGKVR KY IIRYKIADEADVKEVEIDRLKTSTTLTDLSSQRLYNVKVVAVYDEGESLPVVASCYSA

HUMAN a1(XII) 1655 VPAPTNLKITEVTSEGFRGT W DHGASDVS LY RITWGPFGSSDKMETILNGDENTLVFENLNPNTIYEVSITAIYADESESDDLIGSERTLPILTTQAP MOUSE a1(XII) 1669 VPAPTNLQFTEVTPESFRGT W DHGASDVS LY RITWAPVGNPDKMETILNGDENTLVFENLNPNTPYEVSITAIYPDESESEDLSGTE RABBIT a1(XII) 398 VPAPTNLRITEVTPESFRGT W DHGASDVS LY RITWAPFGSSDKMETILNGDENTLVFENLNPNTLYEVSVTAIYPDESESDDLTGSERTSP CHICK a1(XII) 1656 VPSPVNLRITEITKNSFRGT W DHGAPDVS LY RITWGPYGRSEKAESIVNGDVNSLLFENLNPDTLYEVSVTAIYPDESETVDDLIGSERTL

HUMAN a1(XII) 1753 KSGPRNLQVYNATSNSLTVK W DPASGRVQ KY RITYQPSTGEGNEQTTTIGGRQNSVVLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKP MOUSE a1(XII) 1759 KSGPRNLQVYNATSNSLTIK W DPASGRVQ KY RITYQPSTGEGNEQTITVGGRQNSVLLQKLKPDTPYTITVYSQYPGGEGGRMTGRGKTKP RABBIT a1(XII) 489 KSGPRNLQVYNATSNSLTVK W DPASGRVQ KY RITYQPSRGEGNEQTTTIGGRQNSVVLQKLKPDTPYTITVSSLYPDGEGGRMTGRGKTKP CHICK a1(XII) 1757 KSGPRNLQVYNATSHSLTVK W DPASGRVQ RY KIIYQPINGDGPEQSTMVGGRQNSVVIQKLQPDTPYAITVSSMYADGEGGRMTGRGRTKP

HUMAN a1(XII) 1844 LNTVRNLRVYDPSTSTLNVR W DHAEGNPR QY KLFYAPAAGGPEELVPIPGNTNYAILRNLQPDTSYTVTVVPVYTEGDGGRTSDTGRTLM MOUSE a1(XII) 1850 LNTVRNLRVYDPSTSSLSVR W DHAEGNPR QY KLFYAPTSGGPEELVPIPGNTNYAILRNLQPDTPYTITVVPVYTEGDGGRTSDTGRTLV RABBIT a1(XII) 580 LNTVRNLRVYDPSTSTLNVR W DHAEGNPR QY KLFYAPTAGGSEELVPIPGNTNYAILRNL CHICK a1(XII) 1848 LTTVKNMLVYDPTTSTLNVR W DHAEGNPR QY KVFYRPTAGGAEEMTTVPGNTNYVILRSLEPNTPYTVTVVPVFPEGDGGRTTDTGRTLE

HUMAN a1(XII) 1934 RGLARNVQVYNPTPNRLGVR W DPAPGPVL QY RVVYSPVDGTRPSESIVVPGNTRMVHLERLIPDTLYSVNLVALYSDGEGNPSPAQGRTLP MOUSE a1(XII) 1940 RGLSRNIQVYNPTPNSLDVR W DPAPGPVQ QY RIVYSPVAGTRPSESIVVPGNTRTVHLERLIPDTPYSVYIVALYSDGEGNPSPSQGRTLP CHICK a1(XII) 1938 RGTPRNIQVYNPTPNSMNVR W EPAPGPVQ QY RVNYSPLSGPRPSESIVVPANTRDVMLERLTPDTAYSINVIALYADGEGNPSQAQGRTLP

HUMAN a1(XII) 2025 RSGPRNLRVFGETTNSLSVA W DHADGPVQ QY RIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIAVYEDGDGGHLTGNGRTVG MOUSE a1(XII) 2031 RSGPRNIRVFGETTNSLSVA W DHADGPVQ QY RIIYSPTVGDPIDEYTTVPGRRNNVILQPLQPDTPYKITVIAIYEDGDGGHLTGNGRTVG CHICK a1(XII) 2029 RSGPRNLRVFDETTNSLSVQ W DHADGPVQ QY RIIYSPTVGDPIDEYTTVPGIRNNVILQPLQSDTPYKITVVAVYEDGDGGQLTGNGRTVG

HUMAN a1(XII) 2116 LLPPQNIHISDEWYTRFRVS W DPSPSPVL GY KIVYKPVGSNEPMEAFVGEMTSYTLHNLNPSTTYDVNVYAQYDSGLSVPLTDQGTTL MOUSE a1(XII) 2122 LLPPQNIHIFDEWYTRFRVS W DPSPSPVL GY KIVYKPVGSNEPMEAFVGEVTSYTLHNLNPSTTYDVSVYAQYDSGLSVPLTDQGTTL CHICK a1(XII) 2120 LLPPQNIYITDEWYTRFRVS W DPSPSPVL GY KIVYKPVGSNEPMEVFVGEVTSYTLHNLSPSTTYDVNVYAQYDSGMSIPLTDQGTTL

HUMAN a1(XII) 2204 YLNVTDLKTYQIGWDTFCVK W SPHRAAT SY RLKLSPADGTRGQEITVRGSETSHCFTGLSPDTDYGVTVFVQTPNLEGPGVSVKEHTTVKPTEAPTE MOUSE a1(XII) 2210 YLNVTDLKTYQVGWDTFCVK W SPHRAAT SY RLKLSPADGTRGQEITVRGSETSHCFTGLSPEAEYGVTVFVQTPNLEGPGVPIKEQTTVKP CHICK a1(XII) 2208 YLNVTDLTTYKIGWDTFCIR W SPHRSAT SY RLKLNPADGSRGQEITVRGSETSHCFTGLSPDTEYNATVFVQTPNLEGPPVSVREHTVLKPTE

Collagen alpha-1 (XIV)a.k.a. Undulin RAT a1(XIV) ...23 VAPPTRLRYNVISHDSIQIS W KAPRGKFG GY KLLVAPASGGKTNQMNLQNGATKAIIQGLLPEQNYTVQLIAYYKDKESKPAQGQFRI

RAT a1(XIV) ..351 IGPPTELITSEVTARSFMVN W THSPGKVE KY RVVYYPTRGGKPEEVVADGRVSSIVLKNLMSSTEYQIAVFAVSAHTASEGLRGTETTL

RAT a1(XIV) ..453 LPMASDLELYDVTENSMRVK W DAVPGAT GY LILYAPLTEGLAGDEKEMKIGETHTDIELSGLFPNTEYTVTVYAMFGEEASDPATGQETTLP CHICK a1(XIV) 443 LPMASDLKLYDVSHSSMRAK W NGVAGAT GY MILYAPLTEGLAADEKEIKIGEASTELELDGLLPNTEYTVTVYAMFGEEASDPLTGQETTLP

RAT a1(XIV) ..545 LTPPRNLRISNVGSNSARLT W DPTSGKIT GY RIVYTSADGTEINEVEVDPITTFPLKGLTPLTDYSIAIFSIYEEGQSLPLVGEFTTEE CHICK a1(XIV) 535 LSPPSNLKFSDVGHNSAKLT W DPASKNVK GY RIMYVKTDGTETNEVEVGPVSTHTLKSLTALTEYTVAIFSLYDEGQSEPLTGSFTTRK

RAT a1(XIV) ..634 VPAQQYLEIDEVKTDSFRVT W HPLSAEEG QH KLMWIPVYGGKTQEVALKEEQDSYVVEGLDPGTEYEVSLLAVLDDGSESEVVTAVGTTLL CHICK a1(XIV) 624 VPPPQHLEVDEASTDSFRVS W KPTSSDIA FY RLAWIPLDGGESEEVVLSGDADSYVIEGLLPNTEYEVSLLAVFDDETESEVVAVLG RAT a1(XIV) ..725 QTGIRNLVVDDEAATSLRVT W DISDSNVE HF RVTYLTAQGDPKEEVVMVPGVQNSLLLKNLLPDTEYKVTVTPIYTVGEGVSVSAPGKTLP CHICK a1(XIV) 742 RTGVRNLVIDDETTSSLRVV W DISDHNAQ QF RVTYLTAKGDRAEEAIMVPGRQNTLLLQPLLPDTEYKVTITPIYADGEGVSVSAPGKTLP

RAT a1(XIV) ..816 TSGPQNLRVSEEWYNRLRIT W DPPSAPVK GY RIVYKPVSVPGQTLETFVGADVNTIVMTNLLSGMDYNVKIFASQAAGYSDALTG CHICK a1(XIV) 833 LSAPRNLRVSDEWYNRLRIS W DAPPSPTM GY RIVYKSINVPGPALETFVGDDINTILILNLFSGTEYSVKVFASYSTGFSDALTGVAKTL

CHICK a1(XIV) 923 YLGVTNLDTYQVRMTSLCAQ W QLHRHAT AY RVVIESLVDGKKQEVNLGGGVPRHCFFELMPGTEYKISVHAQLQEIEGPAVSIMETTLP

Collagen alpha 1 type XVIII c.el a1 (XVIII) 32 .VPNAPQNVRIKTQSTSATLW W DAPPD-------PTVLIR GY TVEYGEGSISQRILIEGPDSTSFTVTRLSPNTNYVFAVSAYNEAEG c.el a1 (XVIII)136 PPTSVRARIDEKSAAGSAFVS W DDPNPESSSENSIDSTQK QY VINYGIYESDTQQKVRSNAKAVRLTGLIPGKEYEVAVKVVAGDGRESPWS

Immunoglobulin superfamily member 9; NCAM-like protein NRT1. human-NP_065840.1/GI:21357327; mouse-NP_291086.1/GI:18426807 human ..491 .SPHVVTNVSVVALPKGANVS W EPGFDGGYLQ RF SVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGL mouse ..507 .SPHVVTNVSVVPLPKGANVS W EPGFDGGYLQ RF SVWYTPLAKRPDRAHHDWVSLAVPIGATHLLVPGLQAHAQYQFSVLAQNKLGSGPFSEIVLSIPEGLPT

human ..607 .PLSPPRGLVAVRTPRGVLLH W DPPELVPKRLD GY VLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTS mouse ..622 PPLSPPRGLVAVRTPRGVLLH W DPPELIPGRLD GY ILEGRQGSQGWEILDQGVAGTEIQLLVPGLIKDVLYEFRLVAFADSYVSDPSNVANISTSGLEV

Surface glycoprotein CDO,Ig superfamily member human-NP_058648.1/GI:8393084; rat-NP_059054.1/GI:8393087 human 553 PDAPIILSPPQTHTPDTYNLV W RAGKDGGLPIN AY FVKYRKLDDGVGMLGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMITFRTS rat ..574 PDAPNILSPPQTHMPDTYTLV W RTGRDGGMPIN AY FVKYRKLDDGSGAVGSWHTVRVPGSESELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKN

human 697 .PEAPDRPTISTASETSVYVT W IPRANGGSPIT AF KVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAINHYGESFRSSASRPYQ rat ..718 .PEAPDRPTISMASETSVYVT W IPRANGGSPIT AF KVEYKRMKSSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIVINHYGESFRSSASRPYQVAGFPNRFSNR

human 802 PITGPHIAYTEAVSDTQIMLK W TYIPSSNNNTPIQ GF YIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESEFSNVMICETK rat ..823 PITGPHIAYTEAVSDTQIMLK W TYIPSSNNNTPIQ GF YIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICET

brother of CDOhuman-NP_150279.1/GI:15147240; mouse-NP_766094.1 GI:27777681 human 473 .EAPIILSSPRTSKTDSYELV W RPRHEGSGRAPIL YY VVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRR mouse 468 .EAPIILSSPRTSKTDSYELV W RPRHEGSSRTPIL YY VVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTF

human 606 .PEAPDRPTISTASETSVYVT W IPRGNGGFPIQ SF RVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRVRALNMLGESEPSAPSRPYV mouse 601 .PEAPDRPTISTASETSVYVT W IPRGNGGFPIQ SF RVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGESEPSAPSRPYVVSGY

human 713 .VAGPYITFTDAVNETTIMLK W MYIPASNNNTPIH GF YIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGGESEFSNVMICETK mouse 708 .VAGPYITFTDAVNETTIMLK W MYIPASNNNTPIH GF YIYYRPTDSDNDSDYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSNVM

c.elegansUNCoordinated locomotion UNC-22 protein kinasefamily member (unc-22) NP_502274.1 GI:17542662 1596 PKPPKGPLETKNVTAEGLDLV W GTPDPDEGAPVK AY IIEMQEGRSGN W AKVGETKGTDFKVKDLKEHGEYKFRVKALNECGLSDPLTGESVLAKNPYGV 1696 .PGKPKNMDAIDVDKDHCTLA W EPPEEDGGAPIT GY IIERREKSEKD W HQVGQTKPDCCELTDKKVVEDKEYLYRVKAVNKAGPGDPCDHGKPIKMKAKKASPEFT 1831 PTPPKGPLDIADVCADGATLS W NPPDDDGGDPLT GY IVEAQDMDNKGKYIEVGKVDPNTTTLKVNGLRNKGNYKFRVKAVNNEGESEPLSADQYTQIKDPWDE 1994 .PGKPGRPEITDFDADRIDIA W EPPHKDGGAPIE EY IVEVRDPDTKE W KEVKRVPDTNASISGLKEGKEYQFRVRAVNKAGPGQPSEPSEKQLAKPKFI 2188 PSKPNGPLEVSDVFEDNLNLS W KPPDDDGGEPIE YY EVEKLDTATGR W VPCAKVKDTKAHIDGLKKGQTYQFRVKAVNKEGASDALSTDKDTKAKNPYDE 2288 .PGKTGTPDVVDWDADRVSLE W EPPKSDGGAPIT QY VIEKKGKHGRD W QECGKVSGDQTNAEILGLKEGEEYQFRVKAVNKAG 2482 PSSPLGPLEVSNVYEDRADLE W KVPEDDGGAPID HY EIEKMDLATGR W VPCGRSETTKTTVPNLQPGHEYKFRVRAVNKEGESDPLTTNTAILAKNPYEV 2582 .PGKVDKPELVDWDKDHVDLA W NAPDD-GGAPIE AF VIEKKDKNGR W EEALVVPGDQKTATVPNLKEGEEYQFRISARNKAGTGDPSDPSDRVVAKP 2773 PTKPKGPIEVTDVFEDRATLD W KPPEDDGGEPIE FY EIEKMNTKDGI W VPCGRSGDTHFTVDSLNKGDHYKFRVKAVNSEGPSDPLETETDILAKNPFDR 2874 .PDRPGRPEPTDWDSDHVDLK W DPPLSDGGAPIE EY QIEKRTKYGR W EPAITVPGGQTTATVPDLTPNEEYEFRVVAVNKGGPSDPSDASKAVIAKPRNLKPHID 3069 PTSPNGPLDVSDVHGDHVTLN W RAPDDDGGIPIE NY VIEKYDTASGR W VPAAKVAGDKTTAVVDGLIPGHEYKFRVAAVNAEGESDPLETFGTTLAKDPFDK 3171 .PGKTNAPEITDWDKDHVDLE W KPPANDGGAPIE EY VVEMKDEFSPF W NDVAHVPAGQTNATVGNLKEGSKYEFRIRAKNKAGLGDPSDSASAVAKARNVPPVID 3365 PSSPRGPLDVTNIVKDGCDLA W KEPEDDGGAEIS HY VIEKQDAATGR W TACGESKDTNFHVDDLTQGHEYKFRVKAVNRHGDSDPLEAREAIIAKDPFDR 3465 .ADKPGTPEIVDWDKDHADLK W TPPADDGGAPIE GY LVEMRTPSGD W VPAVTVGAGELTATVDGLKPGQTYQFRVKALNKAGESTPSDPSRTMVAKP 3660 PGAPEGPLRHKDITKESVVLK W DEPLDDGGSPIT NY VVEKQEDGGR W VPCGETSDTSLKVNKLSEGHEYKFRVKAVNRQGTSAPLTSDHAIVAKNPFDE 3759 .PDAPTDVTPVDWDKDHVDLE W KPPANDGGAPID AY IVEKKDKFGD W VECARVDGKTTKATADNLTPGETYQFRVKAVNKAGPGKPSDPTGNVVAKP 3953 PGTPEGPLKIDEIHKEGCTLN W KPPTDNGGTDVL HY IVEKMDTSRGT W QEVGTFPDCTAKVNKLVPGKEYAFRVKAVNLQGESKPLEAEEPIIAKNQFDV 4053 .PDPVDKPEVTDWDKDRIDIK W NPTANNGGAPVT GY IVEKKEKGSAI W TEAGKTPGTTFSADNLKPGVEYEFRVIAVNAAGPSDPSDPT 4245 PSAPEGPLEVSDVTKDSCVLN W KPPKDDGGAEIS NY VVEKRDTKTNT W VPVSAFVTGTSITVPKLTEGHEYEFRVMAENTFGRSDSLNTDEPVLAKDPFGT 4346 .PGKPGRPEIVDTDNDHIDIK W DPPRDNGGSPVD HY DIERKDAKTGR W IKVNTSPVQGTAFSDTRVQKGHTYEYRVVAVNKAGPGQPSDSSAAATA 4538 .PGAPENITYPAVSRHTCTLN W DAPKDDGGAEIA GY KIEYQEVGSQI W DKVPGLISGTAYTVRGLEHGQQYRFRIRAENAVGLSDYCQGVPVVIKDPFDP 4637 .PGAPSTPEITGYDTNQVSLA W NPPRDDGGSPIL GY VVERFEKRGGGD W APVKMPMVKGTECIVPGLHENETYQFRVRAVNAAGHGEPSNGSEPVTCRPYVEK 4739 .PGAPDAPRVGKITKNSAELT W NRPLRDGGAPID GY IVEKKKLGDND W TRCNDKPVRDTAFEVKNLGEKEEYEFRVIAVNSAGEGEPSKPSDL 4935 PGKPTGPIRATDIQADAMTLS W RPPKDNGGDAIT NY VVEKRTPG-GD W VTVGHPVGTTLRVRNLDANTPYEFRVRAENQYGVGEPLETDDAIVAKNPFDT 5034 .PGAPGQPEAVETSEEAITLQ W TRPTSDGGAPIQ GY VIEKREVGSTE W TKAAFGNILDTKHRVTGLTPKKTYEFRVAAYNAAGQGEYSVNSVPITADN 5231 .PASPQHIRVEDIAPDCCTLY W MPPSSDGGSPIT NY IVEKLDLRHSDGK W EKVSSFVRNLNYTVGGLIKDNRYRFRVRAETQYGVSEPCELADVVVAKYQFEV 5333 .PNQPEAPTVRDKDSTWAELE W DPPR-DGGSKII GY QVQYRDTSSGR W INAKMDLSEQCHARVTGLRQNGEFEFRIIAKNAAGFSKPSPPSERCQLKSRFGP 5433 .PGPPIHVGAKSIGRNHCTIT W MAPLEDGGSKIT GY NVEIREYGSTL W TVASDYNVREPEFTVDKLREFNDYEFRVVAINAAGKGIPSLPSGPIKIQESGGS 5722 PEAPQGPLHISNIGPSTATLS W RPPVTDGGSKIT SY VVEKRDLSKDE W VTVTSNVKDMNYIVTGLFENHEYEFRVSAQNENGIGAPLVSEHPIIARLPFDP 5823 .PTSPLNLEIVQVGGDYVTLS W QRPLSDGGGRLR GY IVEKQEEEHDE W FRCNQNPSPPNNYNVPNLIDGRKYRYRVFAVNDAGLSDLAELDQTLFQASG 6114 .PEPPRFPIIENILDEAVILS W KPPALDGGSLVT NY TIEKREAMGGS W SPCAKSRYTYTTIEGLRAGK

METALLOPROTEINASES Matrix metalloproteinases (MMP-16) & (MMP-17)HUMAN MMP16 346 NFNTLAILRREMFVFKDQWF W RVRNNRVMD GY PMQITYFWRGLPPSI MOUSE MMP16 346 NFNTLAILRREMFVFKDQWF W RVRNNRVMD GY PMQITYFWRGLPPSI RAT ..MMP16 346 NFNTLAILRREMFVFKDQWF W RVRNNRVMD GY PMQITYFWRGLPPSI

HUMAN MMP16 393 DAVYEN-SDGNFVFFKGNKY W VFKDTTLQP GY PHDLITLGSGIPPHGI MOUSE MMP16 393 DAVYEN-SDGNFVFFKGNKY W VFKDTTLQP GY PHDLITLGNGIPPHGI RAT ..MMP16 393 DAVYEN-SDGNFVFFKGNKY W VFKDTTLQP GY PHDLITLGNGIPPHGI HUMAN MMP17 389 DAVYERTSDHKIVFFKGDRY W VFKDNNVEE GY PRPVSDFSLPPGGI MOUSE MMP17 390 DAVYERTSDHKIVFFKGDRY W VFKDNNVEE GY PRPVSDFSLPPGGI

HUMAN MMP16 440 DSAIWWEDVGKTYFFKGDRY W RYSEEMKTMDP GY PKPITVWKGIPESP MOUSE MMP16 440 DSAIWWEDVGKTYFFKGDRY W RYSEEMKTMDP GY PKPITIWKGIPESP RAT ..MMP16 440 DSAIWWEDVGKTYFFKGDRY W RYSEEMKTMDP GY PKPITIWKGIPESP HUMAN MMP17 435 DAAFSWAHNDRTYFFKDQLY W RYDDHTRHMDP GY PAQSPLWRGVPST MOUSE MMP17 436 DAVFSWAHNDRTYFFKDQLY W RYDDHTRRMDP GY PAQGPLWRGVPSM

HUMAN MMP16 488 QGAFVHKENGFTYFYKGKEY W KFNNQILKVEP GY PRSILKDFMGCDGPTDRVK MOUSE MMP16 488 QGAFVHKENGFTYFYKGKEY W KFNNQILKVEP GY PRSILKDFMGCDGPT RAT ..MMP16 488 QGAFVHKENGFTYFYKGKEY W KFNNQILKVEP GY PRSILKDFMGCDGPT HUMAN MMP17 482 LDDAMRWSDGASYFFRGQEY W KVLDGELEVAP GY PQSTARDWLVCGDSQ ADGSVAAGVD MOUSE MMP17 483 LDDAMRWSDGASYFFRGQEY W KVLDGELEAAP GY PQSTARDWLVCGEP

Matrix metalloproteinases (MMP-3) & (MMP-10) HUMAN MMP-3 295 SFDAVSTLRGEILIFKDRHF W RKSLRKLEP EL HLISSFWPSLPSGV MOUSE MMP-3 295 FFDAVSTLRGEVLFFKDRHF W RKSLRTPEP EF YLISSFWPSLPSNM RAT ..MMP-3 293 SFDAVSTLRGEVLFFKDRHF W RKSLRTPEP GF YLISSFWPSLPSNM HORSE MMP-3 295 SFDAISTLRGEILFFKDRYF W RKTFRTLVP EF HPISSFWPSLPSGI HUMAN MMP10 294 SFDAISTLRGEYLFFKDRYF W RRSHWNPEP EF HLISAFWPSLPSYL MOUSE MMP10 294 SFDSVSTLRGEVLFFKDRYF W RRSHWNPEP EF HLISAFWPTLPSDL RAT ..MMP10 294 SFDAVTMLRGEFLFFKDRHF W RRTQWNPEP EF HLISAFWPSLPSGL

HUMAN MMP-3 341 DAAYEVTSKDLVFIFKGNQF W AIRGNEVRA GY PRGIHTLGFPPTVRKI MOUSE MMP-3 341 DAAYEVTNRDTVFIFKGNQF W AIRGHEELA GY PKSIHTLGLPATVKKI RAT ..MMP-3 339 DAAYEVTNRDTVFILKGNQI W AIRGHEELA GY PKSIHTLGLPETVQKI HORSE MMP-3 341 DAAYEVTSRDSVFIFKGNKF W AIRGNEEQA GY PRGIHTLGFPPTVRKI HUMAN MMP10 340 DAAYEVNSRDTVFIFKGNEF W AIRGNEVQA GY PRGIHTLGFPPTIRKI MOUSE MMP10 340 DAAYEAHNTDSVLIFKGSQF W AVRGNEVQA GY PKGIHTLGFPPTVKKI RAT ..MMP10 340 DAAYEANNKDRVLIFKGSQF W AVRGNEVQA GY PKRIHTLGFPPTVKKI

HUMAN MMP-3 389 DAAISDKEKNKTYFFVEDKY W RFDEKRNSMEP GF PKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC MOUSE MMP-3 389 DAAISNKEKRKTYFFVEDKY W RFDEKKQSMEP GF PRKIAEDFPGVDSRVDAVFEAFGFLYFFSGSSQLEFDPNAKKVTHILKSNSWFNC RAT ..MMP-3 387 DAAISLKDQKKTYFFVEDKF W RFDEKKQSMDP EF PRKIAENFPGIGTKVDAVFEAFGFLYFFSGSSQLEFDPNAGKVTHILKSNSWFNC HORSE MMP-3 389 DAAIFDKEKQKTYFFVEDKY W RFDEKRQSMEP GY PKQIAEDFPGIDSKLDAAFESFGFFYFFSGSSQFEFDPNAKKVTHVLKSNSWFNC HUMAN MMP10 388 DAAVSDKEKKKTYFFAADKY W RFDENSQSMEQ GF PRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC MOUSE MMP10 388 DAAVFEKEKKKTYFFVGDKY W RFDETRHVMDK GF PRQITDDFPGIEPQVDAVLHEFGFFYFFRGSSQFEFDPNARTVTHILKSNSWLLC RAT ..MMP10 388 DAAVFEKEKKKTYFFVGDKY W RFDETRQLMDK GF PRLITDDFPGIEPQVDAVLHAFGFFYFFCGSSQFEFDPNARTVTHTLKSNSWLLC

DROSOPHILA MELANOGASTER Sevenless protein. P13368 GI:14424434 .313 QPQLERAPRADGQSTPLTIR W AMHFPEHYLASRPFNIQYQFVDHHGEELDLEQEDQDASGETGSSAWFNLADYDCDEYYVCEILEALIPYTQYRFRFELPFGENRDEVLY .438 ISAPVIEHLMGLDDSHLAVH W HPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAGTNYTLALSMINKQGEGPVAKGFVQT .824 AGGKPHSLKALLGAQAAKIS W KEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAART 1300 VFVERLATALQEANVSAVLR W DAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPDQTYHFQVEARVAATGAAAGAASHAL 1680 LLLPSSGGSLLKATDCEEQR C LLNLPMITASEDCPLPIPGVRYQLNLTLARGPGSEEHDHGVEPLGQWLLGAGESLNLTDLLPFTRYRVSGILSSFYQKKLALPTLVLAPL 1799 PSPPRNFSVRVLSPRELEVS W LPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRS 1899 FAELPELQLLELGPYSLSLT W AGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPRTRYQCRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPGKPQ

Rat Osteotesticular phosphatase;PTPase, receptor type, V NP_149090.1 GI:14861868 mouse ES cell phosphatase-P70289 GI:3183134 RAT ..36 ..GPLLSVNVSSHGKSTSLFLS W VAAELGGF DY ALSLRSVNSSGSPEGQQLQAHTNESGFEFHGLVPGSRYQLKLTVLRPCWQNVTITLTARTA MOUSE 36 ..GPPLSVSVTSRGRPTSLFLS W VAAEPGGF DY ALCLRAMNLSGFPEGQQLQAHTNESSFEFHGLVPGSRYQLELTVLRPCWQNVTITLTARTA

RAT ..128 PTVVRGLQLHSAGSPARLEAS W SDAPGDQD SY QLLLYHLESQTLACNVSVSPDTLSYSFGDLLPGTQYVLEVITWAGSLHAKTSILQWTE MOUSE 128 PTVVRGLQLHSTGSPASLEAS W SDASGDQD SY QLLLYHPESHTLACNVSVSPDTLSYNFGDLLPGSQYVLEVITWAGSLHAKTSILQWTE

RAT ..218 .PVPPDHLALRALGTSSLQAF W NSSEGAT SF HLMLTDLLGGTNTTAVIRQGVSTHTFLHLSPGTPHELKICASAGPHQIWGPSATEW MOUSE 218 .PVPPDHLRVRALGTSSLQAF W NSSEGAT WF HLILTDLLEGTNLTKVVRQGISTHTFLRLSPGTPYQLKICAAAGPHQIWGPNATEW

RAT ..304 TYPSYPSDLVLTPLRNELWAS W KAGLGARD GY VLKLSGPMESTSTLGPEECNAVFPGPLPPGHYTLQLKVLAGPYDAWVE MOUSE 301 TYPSYPSDLVLTPLWNELWAS W KAGQGARD GY VLKLSGPVENTTTLGPEECNAVFPGPLPPGHYTLGLRVLAGPYDAWVE

RAT ..384 .GSTWLAESAALPREVPGARL W LDGLEASKQPGRRALLYSDDAPGSLGNISVPSGATHVIFCGLVPGAHYRVDIASSTGDISQSISGYTS MOUSE 384 .GSIWLAESAARPMEVPGARL W LEGLEATKQPGRRALLYSVDAPGLLGNISVSSGATHVTFCGLVPGAHYRVDIASSMGDITQSLTGYTS

RAT ..473 PLPPQSLEVISRSSPSDLTIA W GPAPGQLE GY KVTWHQDGSQRSPGDLVDLGPDTLSLTLKSLVPGSCYTVSAWAWAG NLDSDSQKIH SCTR MOUSE 473 PLPPQSLEIISRNSPSDLTIG W APAPGQME GY KVTWHQDGSQRSPGDLVDLGPDISSLTLKSLVPGSCYTVSAWAWSGNLSSDSQKIH SCTR

RAT ..565 PAPPTNLSLGFAHQPAALKAS W YHPPGGRD AF HLRLYRLRPLTLES EKVLPREAQN FSWAQLTAGC EFQVQLSTLW GSERSSSANA TGWT MOUSE 565 PAPPTNLSLGFAHQPATLRAS W CHPPGGRD AF QLRLYRLRPLTLESEKILSQEAQNFSWAQLPAGYEFQVQLSTLWGSEESGSANTTGWT

RAT ..655 PPSAPTLVNVTSDAPTQLQVS W AHVPGGRS RY QVTLYQESTRTATSIMGPKEDGTSFLGLTPGTKYKVEVISWAGPLYTAAANVSAWTY MOUSE 655 PPSAPTLVNVTSEAPTQLHVS W VHAAGDRS SY QVTLYQESTRTATSIVGPKADSTSFWGLTPGTKYKVEAISWAGPLYTAAANVSAWTY

RAT ..744 PLIPNELLVSMQAGSAVVNLA W PSGPLGQGACHAQLSDAGHLSWEQPLKLGQELFMLRDLTPGHTISMSVRCRAGPLQASTHLVVLS MOUSE 744 PLTPNELLASMQAGSAVVNLA W PSGPLGRGTCHAQLSDAGHLSWEQPLSLGQDLLMLRNLIPGHTVSLSVKCRAGPLQASTHPLVLS

RAT ..831 VEPGPVEDVLCHPEATYLALN W TMPAGDVDVCLVVVERLVPGGGTHFVFQVNTSGDALLLPNLMPTTSYRLSLTVLGRNSRWSRAVSLVCSTSAEAWHPP MOUSE 831 VEPGPVEDVFCQPEATYLSLN W TMPTGDVAVCLVEVEQLVPGGSAHFVFQVNTSEDALLLPNLTPTTSYRLSLTVLGGNRQWSRAVTLVCTTSAEVWHPP

Granulocyte colony stimulating factor receptor precursorhuman -Q99062/ GI:729564; mouse -P40223/ GI:729565 human 123 ..PAIPHNLSCLMNLTTSSLICQ W EPGPETHLPT SF TLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVK mouse 124 ..PASPSNLSCLMHLTTNSLVCQ W EPGPETHLPT SF ILKSFRSRADCQYQGDTIPDCVAKKRQNNCSIPRKNLLLYQYMAIWVQAENMLGSSESPKLCLDPMDVVK

human 230 PMLRTMDPSPEAAPPQAGCLQLC W EPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERA mouse 231 PMLQALDIGPDVVSHQPGCLWLS W KPWKPSEYMEQECELRYQPQLKGANWTLVFHLPSSKDQFELCGLHQAPVYTLQMRCIRSSLPGFWSPWSPGLQLRPTMKA

human 334 PTVRLDTWWRQRQLDPRTV--QLF W KPVPLEEDSGRIQ GY VVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRG mouse 335 PTIRLDTWCQKKQLDPGTVSVQLF W KPTPLQEDSGQIQ GY LLSWNSPDHQGQDIHLCNTTQLSCIFLLPSEAQNVTLVAYNKAGTSSPTTVVFLENEG

human 430 PALTRLHAMARDPHSLWVG W EPPNPWPQ GY VIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMA mouse 433 PAVTGLHAMAQDLNTIWVD W EAPSLLPQ GY LIEWEMSSPSYNNSYKSWMIEPNGNITGILLKDNINPFQLYRITVAPLYPGIVGPPVNVYTFAGERAP

human 527 PSHAPELHLKHIGKTWAQLE W VPEPPELGKSPLT HY TIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIIL mouse 531 P-HAPALHLKHVGTTWAQLE W VPEAPRLGMIPLT HY TIFWADAGDHSFSVTLNISLHDFVLKHLEPASLYHVYLMATSRAGSTNSTGLTLRTLDPSDLNIF

C.elegans Hypothetical proteinC34F6.10 CAB03937.1 GI:3874793 752 .PSAPEDVAVSQVQIDRCTVS W TAAEGNGSPII GY VVRMMLNGELFSEHFVTESENETNYRHVLKYLDPNTEYLINIAAKNSVGFSEKIE

C. elegans Hypothetical proteinC27B7.7 CAA90982.1 GI:3874523 648 PDSPPDNLKVLINEANQVIVY W NTPNSTTEVT GY LIYYTRDLSLSNDDYKNWQFVEMNNNSTRYKFDLSVGLKPKTFYRVRISGKNSHADGPASEVVEFETAY

Rat neurofascinNP_446361.1 GI:19924211 (1 of 4) 931 ....PRRFRVRQPNLETINLE W DHPEHPNGILI GY TLRYVPFNGTKLGKQMVENFSPNQTKFSVQRADPVSRYRFSLSARTQVGSGEAATEESP

rat Leukocyte common antigen variant 4 precursor(L-CA) (CD45) (T200). P04157 GI:116008 343 .PEMLPHVQCKNSTNSTTLVS W AEPASKHH GY ILCYKKTPSEKCENLANDVNSFEVKNLRPYTEYTVSLFAYVIGRVQRNGPAKDCNFRTK

Tyrosine-protein kinase receptor UFO (AXL oncogene)Human-P30530/GI:267193 mouse- Q00993/gi:267194 human 426 PLGPPENISATRNGSQAFVH W QEPRAPLQGTLL GY RLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWR mouse 327 PLGPPENVSAMRNGSQVLVR W QEPRVPLQGTLL GY RLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVTAYTSAGDGPWSLPVPL

Bifidobacterium protein.....1906 NSGQPLDVTDLAVAADGNYA W SVKVTGGP GY SGLDNTADGGSVAGTRPSDSSEGTKSLKSGTDVTTLAKNPWILGFGNTPISSTTIHKQ

Hosted by www.Geocities.ws