Apoptosis-related Receptors
human Lymphocyte-associated receptors
of death (LARD-1 to LARD-11)
human TRAMP fetal lung; Human TRAMP' brain
human Death domain receptor-3
human Apoptosis-inducing Receptor
human Apo-3
human WSL-splice varients
hLARD11 1 ...RPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF
HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hLARD9 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hLARD8 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAA----------------------
hLARD7 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PA-----------------------
hLARD6 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAA----------------------
hLARD5 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAA----------------------
hLARD3 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hLARD2 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hLARD1B 1 MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF
HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hLARD1A 1 MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF
HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
.TRAMP' 1 ...AAAG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF
HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
.TRAMP .1
...AAAG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
.hDDR3 .1
......G C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hApoIR .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
.Apo-3 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
WSL-1R .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
WSL-S1 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
WSL-S2 .1
MEQRPRG C AAVAAALLLVLLGARAQGGTRSPR C D C AG DF HKKIGLFC C RG C PAGHYLKAP C TEPCGNSTCLV C
hLARD1171 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD9 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD8 55 --------------------------------SQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD7 54 -----------------------------------------------------------------------------------------
hLARD6 55 --------------------------------SQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD5 55 --------------------------------SQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD3 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD2 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD1B74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD1A74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
TRAMP' 71 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
TRAMP .71
PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hDDR3 .68
PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hApoIR 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
Apo-3 .74
PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C KP GW
FVE C QVSQ C VSSSPFY CQPCLD
WSL-1R 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
WSL-S1 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
WSL-S2 74 PQDTFLAWENHHNSE C AR C QA C DEQASQVALEN C SAVADTR C G C
KP GW
FVE C QVSQ C VSSSPFY CQPCLD
hLARD11 141 .........................C GALHRHTRLL C SRRDTD C GT C
LP GF
YEHGDG C VS C PT.
hLARD9 .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C PT.
hLARD8 ..99 .........................C GALHRHTRLL C SRRDTD
C GT C
LP GF
YEHGDG C VS C PT.
hLARD6 ..99 .........................C GALHRHTRLL C HPSVTLGQRPHPSSTS.
hLARD5 ..99 .........................C GALHRHTRLL C SRRDTD
C GT C
LP GF
YEHGDG C VS C PT.
hLARD3 .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P.
hLARD2 .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P.
hLARD1B 144 .........................C GALHRHTRLL C SRRDTD C GT C
LP GF
YEHGDG C VS C P.
hLARD1A 144 .........................C GALHRHTRLL C SRRDTD C GT C
LP GF
YEHGDG C VS C P.
TRAMP' .141
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C PT.
TRAMP ..141
.........................C GALHRHTRLL C SRRDTD C GT C LL GF
YEHGDG C VS C P
hDDR3 ..138
.........................C GALHRHTRLL C SRRDTD C GT C LL GF
YEHGDG C VS C P
hApoIR .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P
Apo-3 ..144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P
WSL-1R .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P
WSL-S1 .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P.
WSL-S2 .144
.........................C GALHRHTRLL C SRRDTD C GT C LP GF
YEHGDG C VS C P
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human MIHB (Inhibitor
of Apoptosis)
MIHB 1 mhktasqrlfpgpsyqniksimedstilsdwtnsnkqkmkydfs
c elyrmstystfpagv
MIHC 1 .................mnivensiflsnlmksantfelkydls c elyrmstystfpagv
MIHB 61 pvserslara gf yytgvndkvk c
fc c glmldnwklgdspiqkhkqlyps c sfiqnl-vsas
MIHC 44 pvserslara gf yytgvndkvk c fc c glmldnwkrgdsptekhkklyps c rfvqslnsvnn
MIHB 121 lgstskntspmrns-fahslsptlehsslfsgsysslspnp-nsravedisssrtnpysyamsteearfltyhmwpltfls
MIHC 105 leatsqptfpssvtnsthsllpgtensgyfrgsysnspsnpvnsranqdfsalmrssyhcamnnenarlltfqtwpltfls
MIHB 201 ..pselara gf yyigpgdrva c fa c ggklsnwepkddamsehrrhfpn c pflensle
MIHC 186 ..ptdlaka gf yyigpgdrva c fa c ggklsnwepkdnamsehlrhfpk c pfienqlq
MIHB 256 .tlrfsisnlsmqthaarmrtfmywpssvpv
MIHC 241 dtsrytvsnlsmqthaarfktffnwpssvl
MIHB 286 .qpeqlasa gf yyvgrnddvk c
fc c dgglr c wesgddpwvehakwfpr c eflirmk
MIHC 271 vnpeqlasa gf yyvgnsddvk c fc c dgglr c wesgddpwvqhakwfpr c eylirikgqef
MIHB 341 gqefvdeiqgryphlleqllstsdttgeenadppiihfgpgesssedavmmntpvvksalemgfnrdlvkqtvqskiltt
MIHC 331 ....irqvqasyphlleqllstsdspgdenaessiihfepgedhsedaimmntpvinaavemgfsrslvkqtvqrkilatgeny
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Human Tumor Necrosis Factor
Receptors
TNFR1 .21 ............GIHPSGVTGLVPSLGDREKRDNL
C
PQG KY
AHPKNNSI C
TNFR2 .21
................HALPAQVAFTPYAPEPGST C RLR EY
YDQTAQM C
TNFR1 .60
..C
TK C --HKGTYLVSD C PSPGQETV CEV C DKG TF TASQNHVRQ C L
TNFR2 .54
..C
SK C --SPGQHAKVF C TK-TSDTV CDS C EDS TY TQLWNWVPE C L
TNFR1 101 S C KT- C RKEMFQVEISP C KADMDTV C G C KKN QF
QRYLSETHFQ C V
TNFR2 105 S C GSR C --SSDQVETQA C TREQNRI C T C RPG WY
CALSKQEG C R
TNFR1 145 .D C SP--- C FNGT-VTIPCKEKQNTV
C N- C
H-A GF
FLSGNE C T...
TNFR2 136 .L C APLRK C RPGFGVARPGTETSDVV C KP C APG TF
SNTTSSTDI C R...
Human TRAIL receptors (DR5/TRAIL-R2)
hTRAIL (R2/DR5) 61 ............lapqqraapqqkrsspsegl
c ppghhisedgrd c is c kygq dy sthwndllf c l
hTRAIL? .......121 .....................qqwehsplgel c ppgshrserpga c nr c tegv gy tnasnnlfa
c l
hTRAIL-R4A&B... 61.......... qdevpqqtvapqqqrrslkeee c pagshrseytga c np c tegv
dy tiasnnlps c l
hTRAIL-R3 ......61 vlaysattarqeevpqqtvapqqqrhsfkgee c pagshrsehtga
c np c tegv dy tnasnneps c f
hTRAIL-R3' .....41.......... qeevpqqtvapqqqrhsfkgee c pagshrsehtga c np c tegv
dy tnasnneps c f
hdecoy-R2 ......61.......... qdevpqqtvapqqqrrslkeee c pagshrseytga c np c tegv
dy tiasnnlps c l
hdecoy-R1 ......31.......... qeevpqqtvapqqqrhsfkgee c pagshrsehtga c np c tegv
dy tnasnneps c f
hLIT ...........51.............................. ee c pagshrsehtga c np c tegv dy tnasnneps c f
TRUNND......... 61.......... qdevpqqtvapqqqrrslkeee c pagshrseytga c np c tegv
dy tiasnnlps c l
hTRICK-2A&B ....61 ............lapqqrvapqqkrsspsegl c ppghhisedgrd c is c kygq
dy sthwndllf c l
hTRID ..........25.... sattarqeevpqqtvapqqqrhsfkgee c pagshrsehtga c
np c tegv dy tnasnneps c f
hFASLR(CD95)....51......... eglhhdgqf c hkp c ppgerkard c tvngdepd c vp c
qegk ey tdkahfssk c r
MoFASLR ........41... kn c seglyqggpf c cqp c qpgkkkved c kmnggtpt c
ap c tegk ey mdknhyadk c r
BoFASLR ........42...ans c qeglyrehqf c cqp c ppgkrkngd c krdgdtpe
c vl c segn ey tdkshhsdk c i
hTRAIL DR5 ....115 .....................r c tr c dsgevelsp c tttrntv c q c eeg tf reedspem
c r
hTRAIL? .......166 .....................p c ta c ksdeeersp c tttrnta c q c kpg tf rndnsaem
c r
hTRAIL-R4A&B ..117 .....................l c tv c ksgqtnkss c tttrdtv c q c ekg sf qdknspem
c r
hTRAIL-R3 .....126 .....................p c tv c ksdqkhkss c tmtrdtv c q c keg tf rnenspem
c r
hTRAIL-R3' .....87 .....................p c tv c ksdqkhkss c tmtrdtv c q c keg tf rnvnspem
c r
hdecoy-R2 .....117 .....................l c tv c ksgqtnkss c tttrdtv c q c ekg sf qdknspem
c r
hdecoy-R1 ......87 .....................p c tv c ksdqkhkss c tmtrdtv c q c keg tf rnenspem
c r
hLIT ...........87 .....................p c tv c ksdqkhkss c tmtrdtv c q c keg tf rnenspem
c r
TRUNND ........117 .....................l c tv c ksgqtnkss c tttrdtv c q c ekg sf qdknspem
c r
hTRICK-2A&B ...115 .....................r c tr c dsgevelsp c tttrntv c q c eeg tf reedspem
c r
hTRID ..........87 .....................p c tv c ksdqkhkss c tmtrdtv c q c keg tf rnenspem
c r
hFASLR ........103 .....................r c rl cdeghgleveinc trtqntk c r c kpn ff c nstv c
e
MoFASLR ........98 .....................r c tl cdeehglevetnc tltqntk c k c kpd fy c dspg c
e
BoFASLR .......100 .....................r c si cdeehgleveqnc trtrntk c r c ksn ff c nssp c
e
hTRAIL DR5 ..155 k c rtg c --prgmvkvgd c tpwsdie c vh...
hTRAIL? .....105 k c stg c --prgmvkvkd c tpwsdie c vh...
hTRAIL-R4A&B 157 t c rtg c --prgmvkvsn c tprsdik c ....
hTRAIL-R3... 167 k c -sr c --psgevqvsn c tswddiq c ve...
hTRAIL-R3' ..127 k c -sr c --psgevqvsn c tswddiq c ve...
hdecoy-R2 ...157 t c rtg c --prgmvkvsn c tprsdik c
hdecoy-R1 ...127 k c -sr c --psgevqvsn c tswddiq c ve..
hLIT ........127 k c -sr c --psgevqvsn c tswddiq c ve...
TRUNND ......157 t c rtg c --prgmvkvsn c tprsdik c ...
hTRICK-2A&B .155 k c rtg c --prgmvkvgd c tpwsdie c vh
hTRID .......127 k c -sr c --psgevqvsn c tswddiq c ve...
hFASLR ......142 h c -dp c -tkcehgiike c tltsntk c keegsrsnlgwl c ll...
MoFASLR .....128 h c -vr c -ascehgtlep c tatsntn c rkqsprnrlwlltilvlli...
BoFASLR .....139 h c -np c -ttcehgiiek c tptsntk c kgsrshanslwallilli...
Human TUMOR NECROSIS FACTOR-INDUCIBLE
PROTEIN TSG-6
.71 ....LEAARKIGFHV C AAGWMA--K--GRV- GY PIVKPGPN- C GFGKTGIIDYGIRLNRSERW
124 ..DAY C YNPHAKE C GGVFTD-PKRIFKSP GF PNEYEDNQI C YWHIRLKYGQRIHLSFLDF
181 ........DLEDDPG C LADYVEIYDSYDDVH GF VGRY----- C GDELPDDIISTGNVMTLKF...
Osteoproteregin OPG (involved in regulation of Bone Density)
Human OPG 21 ........qetfppkylhydeetshqll c dk c ppg ty lkqh c takwkt
Rat.. OPG 21 ........qetfppkylhydpetgrqll c dk c apg ty lkqh c tvrrkt
Mouse OPG 21 ........qetlppkylhydpetghqll c dk c apg ty lkqh c tvrrkt
Human OPG 61 ...........................v c ap c pdh yy tdswhtsde c l
Rat.. OPG 61 ...........................l c vp c pdy sy tdswhtsde c v
Mouse OPG 61 ...........................l c vp c pdh sy tdswhtsde c v
Human OPG 81 y c spv c kelqyvkqe c nrthnrv c e c keg ry leief c lk
Rat.. OPG 81 y c spv c kelqtvkqe c nrthnrv c e c eeg ry lelef c lk
mouse OPG 81 y c spv c kelqsvkqe c nrthnrv c e c eeg ry leief c lk
Human OPG 121 ....hrs c ppgfgvvqagtperntv c kr c pd gf
fsnetsskap c rkhtn c svfgllltqkgnat
Rat.. OPG 121 ....hrs c ppglgvlqagtperntv c kr c pd gf
fsgetsskap c rkhtn c sslgllliqkgnat
Mouse OPG 121 ....hrs c ppgsgvvqagtperntv c kk c pd gf
fsgetsskap c ikhtn c stfgllliqkgnat
Human OPG 181 .......hdni c sgnsestqk c gidvtl c ee af frfavptkftpnwlsvlvdnlpgtkvnaesveri...
Rat.. OPG 181 .......hdnv c sgnreatqn c gidvtl c ee af frfavptkiipnwlsvlvdslpgtkvnaesveri...
Mouse OPG 181 .......hdnv c sgnreatqk c gidvtl c ee af frfavptkiipnwlsvlvdslpgtkvnaesveri..