THE FOLLOWING ARTICLE IS ALL IN MY OPINION, AND CONTAINS MY SUGGESTIONS, BASED ON MY PERSONAL EXPERIENCE.

YOU ARE AS ALWAYS AT YOUR OWN RISK

PLEASE CONSULT YOUR DOCTOR OR HEALTH CARE PROFESSIONAL

I have debated with myself whether I should post these articles. This is still very new territory, and risky business. Many things are not known. I know that I would want to know such information and I like to make my own decisions about what risks I take, so I'm going to go ahead. If things go wrong I don't blame anyone else. Please understand that nothing can be guaranteed. You must accept responsibility for whatever risk you take. This may or may not work for you.

For my source of Quercetin I initially used a "Hay Fever and Sinus" Formula. I think these formulas are not desirable sources of Quercetin, because they typically contain several other ingredients.

I then started using Orthoplex Lymphodram from BioOrganics in Kelvin Grove, Brisbane.

This contains
Quercetin 200mg
Rutin 500mg
Ascorbic Acid 50mg
Rutin is a form of Quercetin and almost identical, but I'm not absolutely sure if it has identical properties.

For Calcium-spirulan I used 1 gram Spirulina tablets. These are available from most vitamin and health food stores.

Beta Carotene is referred to as a pro-vitamin. It is converted by the body into Vitamin A on an as needed basis.

The fat soluble vitamins are A, D and E. They are stored in the liver.

Vitamin C and the B complex vitamins are water soluble and are not stored.

The Flavanoids were once considered Vitamins, and are no doubt related. My experience suggests that Quercetin and Calcium-spirulan are being stored in the body, probably the liver, like fat-soluble vitamins. Even a month after I stopped taking Quercetin and Spirulina, I still experienced side effects from using Vitamin C and Calcium.

I shall use the word pro-inhibitor to refer to Quercetin or Spirulan and co-factor to refer to Vitamin C or Calcium, since both seem to behave in a similar fashion. When the pro-inhibitor reactors with the co-factor, an active anti-viral results, which I shall call an active-inhibitor.

When the pro-inhibitor Quercetin reacts with it's co-factor Vitamin C it creates an active CK2 inhibitor - a Quercetin glycoside?

When the pro-inhibitor spirulan reacts with its co-factor calcium, it creates an active CK2 inhibitor - calcium-spirulan.

The pro-inhibitors appear to be relatively inert, and I suspect are stored in the liver like fat-soluble vitamins. Repeated dosing of pro-inhibitor will result in accumulation of a pool of inert pro-inhibitor in the body. Once you have taken any amount of pro-inhibitor, you are committed to that amount, for a long period of time. Eventually accumulation of pro-inhibitor will "overflow" and severe side effects will result.

There is a maximum amount of pro-inhibitor, which when it reacts with the corresponding maximum amount of co-factor, creates a concentration of active-inhibitor which is at the top of the efficacy zone. If either pro-inhibitor is less than maximum or co-factor is less than maximum this will still result in concentration of active-inhibitor which is in the zone.

It is desirable for pro-inhibitor to NOT be beyond the maximum. In this case it is possible to use amounts of co-factor beyond the maximum, which is nutritionally desirable.

If pro-inhibitor is beyond the maximum, it is still possible to use less than or equal maximum amounts of co-factor to obtain a concentration of active-inhibitor, which is in the zone.

These maximum amounts are "fuzzy", not exact.

Half-life of active-inhibitor, which is in the zone, appears to be from one half to one day.

The following is a simplified and approximate model for dosing pro-inhibitors and co-factors.

For a person using Quercetin or Spirulina, at any given time there are the following possible scenarios

1. The amount of pro-inhibitor in the body is less than or equal the maximum amount.

In addition, either of the following:

1. The amount of co-factor is less than or equal to maximum co-factor. This results in concentration of active-inhibitor, which is in the efficacy zone.
2. The amount of co-factor is greater than maximum co-factor. This will still result in concentration of active-inhibitor in the efficacy zone, since no more than the maximum amount of pro-inhibitor is available to react with the co-factor.

1. The amount of pro-inhibitor in the body is more than the maximum amount.

In addition either of the following:

1. The amount of co-factor is less than or equal to the maximum co-factor. This again results in concentration of active-inhibitor which is in the efficacy zone, since there is no more than maximum amount of co-factor to react with pro-inhibitor. The remainder of the pro-inhibitor will remain inert.
2. The amount of co-factor is greater than maximum co-factor. This will result in concentration of active-inhibitor, which is beyond the top of the efficacy zone.

In all the following cases, I suggest using sleeplessness as a sign of active-inhibitor being at the top of or beyond the efficacy zone. This does not have to be exact, occasional sleeplessness will occur, but it shouldn't happen night after night.

I also suggest anyone who has already been using Quercetin or Spirulina to stop taking them. Like me, you're probably in Scenario 2.

Scenario 2b is the only one which results in concentration of active anti-viral beyond the efficacy zone.

A person in 2b may be continuing to dose pro-inhibitor and using large amounts of co-factor. It is easy to come out of this scenario - stop both. When sleep is O.K (1 or 2 days), attempt can be made to get into 2a, using small doses of co-factor. This has been my strategy for the last month.

A person in 2b may not be dosing pro-inhibitor, but may be using amounts of co-factor that are too large. This requires simply reducing co-factor.

There may be people already in Scenario 2a who are continuing to dose pro-inhibitor, but are using less than or equal the maximum amount of co-factor. There may not be obvious problems or sleeplessness, but this in time is going to almost certainly be a problem. All that is necessary then is to stop dosing pro-inhibitor, and continue with small doses of co-factor.

Hopefully everyone in time will be able to migrate into Scenario 1b.

If you have already taken any amount of Quercetin or Spirulina, stop taking them, and start using small amounts of co-factor - Vitamin C or Calcium. Dosing of co-factor does not have to be absolutely exact. It should be modified on a daily basis according to personal experience, using sleeplessness as a sign of overdose of co-factor. I also regard peculiar sensations in the heart as a sign of impending overdose. The heart should probably be monitored.

Scenario 1b is the ideal scenario, because nutritionally desirable amounts of co-factor can be used. This may be an option for people who have not yet used Quercetin or Spirulina and who wish to experiment.

Scenario 1b: Nutritionally desirable amount of co-factors

Vitamin C: At least 1 gram (1000mg)

Calcium: Approx. 1 gram

Scenario 2a: APPROX amount of co-factors:

Start at the low end of these doses, and increase on a day by day basis.

Vitamin C: 50-500mg

Calcium: 50-200mg

Calcium and Vitamin C in food must be taken into account

Vitamin C is in most fruit and a lot of vegetables. Heat destroys Vitamin C, so cooked vegetables are a possibility.

Can use fruit in the morning, and then you have to avoid it for the rest of the day.

Calcium is in most dairy products - Milk, yoghurt, cheese, ice-cream etc. Also eggs and canned salmon - due to soft bones. Can also use these in the morning only, and then avoid for the rest of the day.

For those who have used Quercetin, you have to avoid onions like the plague, and anything in the onion family: garlic, spring onions, scallions leeks etc. Onions are in everything; it's a pain in the neck. You have to examine labels VERY carefully. Any amount of onion seems to bring on problems with sleep, especially if it's at night. You also have to avoid apples and tea.

In general, the evening meal, or anything eaten in the evening requires the most care. Any mistakes here - using any significant amount of co-factor, will cause a problem with sleep.

You also have to be careful of anything that contains herbs. I recently discovered my new fiber supplement contains Glycyrrhiza glaba (Licorice) root, which is probably a CK2 Inhibitor. This can push you towards overdose again.

It seems to me that Spirulina may be the best bet, because Quercetin is in Onions, and onions are very common in prepared food. This is a real nuisance.

Certainly continue current combination therapy.

Start with a one very small dose - 1/8 tablet (1/8 gram) of Spirulina with 200mg of calcium. On subsequent days experiment everyday with increasing amounts of Calcium only up to 1gram, for at least a week. Total calcium per day must include calcium in foods. Once you take Spirulina, it's stored away in the body for a long time, so you have to go real slow with dosing it, and once you're in the zone, you won't need to re-dose it for a long time either.

Don't tolerate sleeplessness on a day after day basis, it's definitely not good for you. Reduce or avoid daily Calcium.

Like many drugs, there can be constipation, so a good fiber supplement is necessary.

Remember these are inhibitors. They are NOT chemotherapy. Infected cells are not being destroyed. Highly replicating cells (cells that are producing large amounts of virus) are being converted to low level replication because of inhibition of activated CK2. You want to be in the zone, not above it.

I suspect the immune system will find it much easier to control the virus when there are only low-level replication cells. Existing drugs will have fewer problems with resistance.

Best of all, although it remains to be verified by experience, I think the argument is pretty strong that there will not be resistance to CK2 Inhibitors.