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Perimenopause Naturally:
An Integrative Medicine Approach
by Tori Hudson, N.D.

Perimenopause Naturally:
An Integrative Medicine Approach
by Tori Hudson, N.D.

Red Clover Isoflavones

Red clover is a member of the legume family and has been
used worldwide as a source of hay for cattle,
horses and sheep and by humans as a source of protein
in the leaves and young sprouts.
Historically, it has also been recognized as a medicinal plant
for human use and, more recently, as a menopausal herb.

In four clinical trials conducted on the effect
of red clover isoflavones on vasomotor symptoms,
two showed benefits and two did not.
The first two published studies showed no statistically
significant difference between the red clover
standardized extract and the placebo
during a 3 month period, although both groups did improve.[7]
It was suggested that the negative results of these studies
were due to inadequate controls and that
women in the control group were, in fact,
getting meaningful amounts of phytoestrogens in their diet.

Two other studies of 40 mg standardized extract of red clover
produced a 75% reduction in hot flashes
after 16 weeks in 30 women.
The difference between placebo and red clover isoflavones
was statistically significant.[8]

A similar study evaluated
40 mg of red clover standardized isoflavones
for two months in 23 post-menopausal women and found
that red clover users had a 54% reduction in hot flashes
versus 30% in the placebo group.[9]

The 4 studies also revealed
other intriguing results of red clover:
no endometrial thickening,
an increase in HDL ("good cholesterol"), and no
abnormalities in liver function tests, CBC, or estradiol.
Another study showed that red clover isoflavones may reduce coronary vascular disease
by increasing arterial elasticity by 23%.[10]


Perimenopause: signs and symptoms
Individual assessments and recommendations
Principles of naturopathic medicine

Natural therapies for perimenopause:
the scientific facts

ISOFLAVONES
SOY



SOURCES

This article first appeared in A Friend Indeed (Jan/Feb 2002),
the newsletter for women in menopause and midlife.

Notes
Endnotes

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