Table 7

Study 203

Mean (X) CGI-I (Values less than four represent improvement)

LAST OBSERVATION CARRIED FORWARD ANALYSIS

Treatment

Groups

Treatment Week

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

N

X

N

X

N

X

N

X

N

X

N

X

N

X

N

X

N

X

BUP SR 150 (L)

120

4.0

113

3.5

120

3.1

120

2.7

120

2.6

120

2.6

120

2.5

120

2.5

120

2.4

BUP SR 300 (II)

113

4.0

113

3.6

113

3.1

113

2.8

113

2.7

113

2.6

113

2.5

113

2.6

113

2.4

Placebo (P)

117

4.0

116

3.5

117

3.2

117

3.1

117

3.0

117

2.9

117

2.9

117

2.9

117

2.9

2-sided p-values for pairwise comparisons

I. vs. P

*

1.0

0.2

0.01

0.006

0.01

0.04

0.01

0.009

II vs. P

0.7

0.3

0.09

0.08

0.07

0.03

0.05

0.009

OBSERVED CASES ANALYSIS

Treatment

Groups

Treatment Week

Baseline

Wk 1

Wk 2

Wk 3

Wk 4

Wk 5

Wk 6

Wk 7

Wk 8

N

X

N

X

N

X

N

X

N

X

N

X

N

X

N

X

N

X

BUP SR 150 (L)

120

4.0

113

3.5

109

3.0

98

2.6

89

2.4

83

2.2

70

2.1

67

1.9

64

1.8

BUP SR 300 (II)

113

4.0

113

3.6

109

3.0

98

2.7

87

2.6

77

2.4

74

2.1

69

2.1

62

1.8

Placebo (P)

117

4.0

116

3.5

112

3.2

102

3.0

91

2.8

75

2.6

69

2.2

64

2.1

56

2.1

2-sided p-values for pairwise comparisons

I. vs. P

*

1.0

0.2

0.02

0.008

0.04

0.4

0.2

0.06

II vs. P

0.7

0.2

0.2

0.2

0.2

0.3

0.8

.006