11c
Table 2: Individual Plasma Concentrations of
Bupropion and 306U73 in Rats
on Day 5 Following and Oral Adminstration of
Bupropion (MUT 223)
|
|
UAIN* 93-Prefix |
Gender |
Time
(hr) |
Bupropion (ng/mL) |
306U73 (ng/mL) |
|
GROUP
9 |
6657 |
male |
0.5 |
181 |
349 |
|
300
mg/kg/day |
6658 |
male |
0.5 |
125 |
171 |
|
(with
impurities) |
6659 |
male |
0.5 |
89 |
81 |
|
|
6660 |
male |
0.5 |
432 |
215 |
|
|
6661 |
male |
0.5 |
483 |
471 |
|
GROUP
10 |
6662 |
male |
0.5 |
106 |
225 |
|
300
mg/kg/day |
6663 |
male |
0.5 |
115 |
271 |
|
(without
impurities) |
6664 |
male |
0.5 |
92 |
221 |
|
|
6665 |
male |
0.5 |
147 |
337 |
|
|
6666 |
male |
0.5 |
122 |
365 |
|
GROUP
9 |
6712 |
female |
0.5 |
595 |
883 |
|
300
mg/kg/day |
6713 |
female |
0.5 |
2040 |
1246 |
|
(with
impurities) |
6714 |
female |
0.5 |
3046 |
2226 |
|
|
6715 |
female |
0.5 |
929 |
1021 |
|
|
6716 |
female |
0.5 |
430 |
561 |
|
GROUP
10 |
6717 |
female |
0.5 |
2285 |
693 |
|
300
mg/kg/day |
6718 |
female |
0.5 |
391 |
114 |
|
(without
impurities) |
6719 |
female |
0.5 |
730 |
1067 |
|
|
6720 |
female |
0.5 |
1067 |
555 |
|
|
6721 |
female |
0.5 |
1247 |
1164 |
|
*Unique
Animal Identification Number |
|||||
TBZZ/93/0060 7
100
TTEP/93/0058 103
ITEM
5
Back a Page
Next Page
Back to Wellbutrin SRŪ NDA Index Page
Back to Main
Index