Table
12: Percentage of Cells with Non-Diploid Chromosome Nos
A Cytogenetic Study in Rats
with Five Daily doses of 323U68-HCl
(Bupropion: Containing impurities)
PERCENTAGE OF CELLS WITH
NON-DIPLOID CHROMOSOME NUMBERS (MUT 223)
|
Dose (mg/kg) |
% Cells: |
|
24
Hr. Sacrifice
|
|
|||
|
|
Males |
Females |
Combined |
|
|||
|
0 |
Hypodiploid: |
|
14.8 |
7.6 |
11.2 |
|
|
|
|
Hyperdiploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
0 |
Hypodiploid |
|
6.8 |
8.4 |
7.6 |
|
|
|
|
Hyperdiploid: |
|
0.4 |
0.0 |
0.2 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
100 |
Hypodiploid |
|
12.8 |
16.0 |
14.4 |
|
|
|
|
Hyperdiploid: |
|
0.4 |
1.2 |
0.8 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
200 |
Hypodiploid |
|
14.4 |
11.2 |
12.8 |
|
|
|
|
Hyperdiploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
300 |
Hypodiploid |
|
10.8 |
8.8 |
9.8 |
|
|
|
|
Hyperdiploid: |
|
0.8 |
0.4 |
0.8 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
300* |
Hypodiploid |
|
11.2 |
6.8 |
9.0 |
|
|
|
|
Hyperdiploid: |
|
0.0 |
0.4 |
0.2 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
Positive
Control |
Hypodiploid |
|
10.4 |
12.0 |
11.2 |
|
|
|
(CP:
30 mg/kg) |
Hyperdiploid: |
|
0.4 |
0.4 |
0.4 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
Positive
Control |
Hypodiploid |
|
18.0 |
16.8 |
16.4 |
|
|
|
(CP:
40 mg/kg) |
Hyperdiploid: |
|
1.2 |
0.0 |
0.6 |
|
|
|
|
Polyploid: |
|
0.0 |
0.0 |
0.0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
*
Test compound used for this group was the material presently used in clinics. |
|||||||
TTEP/93/0058 32
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