Table 8: Pharmacokinetic Parameters for Bupropion and 306U73 in Pregnant Rats on Day 15 of Gestation after an Oral Administration of Bupropion (TOX 652)
|
|
Bupropion |
306U73 |
||||
|
|
AUC (ng/mL*hr) |
Cmax (ng/mL) |
Tmax (hr) |
AUC (ng/mL*hr) |
Cmax (ng/mL) |
Tmax (hr) |
|
GROUP
1 75
mg/kg/day (with
impurities) |
3119 |
1848 |
0.5 |
1912 |
570 |
0.5 |
|
GROUP
2 150
mg/kg/day (with
impurities) |
2162 |
2056 |
0.5 |
2682 |
945 |
0.5 |
|
GROUP
3 300
mg/kg/day (with
impurities) |
2885 |
1766 |
0.5 |
6899 |
1916 |
0.5 |
|
GROUP
4 300
mg/kg/day (without
impurities) |
3085 |
1666 |
0.5 |
6696 |
2182 |
0.5 |
TBZZ/93/0059 11
100
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