4.d Describe the type of
environmental present at and adjacent to production and disposal sites.
The United States production site where both drug substances
synthesis and product formulation will take place is located on the outskirts
of Greenville, North Carolina. The
manufacturing plant is situated in an industrial park surrounded by mostly
rural areas. Greenville is in a coastal
plain region in a temperate zone.
Treatment and/or disposal of rejected or returned
goods will take place both on site at the Burroughs Wellcome Co. wastewater
pretreatment plant and solid waste incineration facility, and off site at the
Greenville Utilities Commission (GUC) Wastewater Treatment Plant, and the
Bertie County Regional Landfill.
The Burroughs Wellcome Co. on-site wastewater
pretreatment facility is located in the northeastern section of the plant
within the Environmental Complex. Unit
operations consist of first and second stage aeration tanks for biological stabilization,
secondary clarifiers for removal of sludge solids, a neutralization tank, surge
tanks, and effluent discharge with flow monitoring equipment. The pretreatment facility is designed to
handle a maximum sustained daily flow rate of 410,000 gallons. Flexibility to operate within a wide range
of organic and hydraulic loading is provided by a system of surge tanks for
high strength wastewater or hydraulic surges in excess of the design
capacity. Effluent from the
pretreatment plant is discharged to the GUC wastewater treatment plant. The plant operates under a permit granted by
GUC, No. BW01-98.
The on-site incineration facility is also located in
the Environmental Complex and houses a 2000 lb/hr controlled air solid waste
incinerator, flux forced collision scrubber, automatic waste feed through a
rotary shear shredder, and nearly 2000 sq. ft of storage space. The incinerator/scrubber combination have
been designed to meet or exceed Federal and State air quality limitations on
particulates and chlorides. The
facility is operated under permits granted by both the N.C. Division of Solid
Waste, Permit No. 74-03-) and the N.C. Air Quality Management Section, Permit
No. 5754R52.
The GUC Wastewater Treatment Plant is situated in an
area of mixed industry and rural settings.
The treatment plant serves the City of Greenville and contiguous
areas. Treated wastewater from the
plant is discharged into the Tar River, which empties into the Pamlico
Sound. GUC operates the Wastewater
Treatment Plant under authority granted by the North Carolina Division of
Environmental Management, NPDES Permit No. NC002393.
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