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Markers in breast cancer

Von Willebrand factor
(VWF)



Other name(s)

???


Molecular biology

Gene: VWF maps to 12p13. The VWF gene is approximately 178 kb long and contains 52 exons. The exons vary from 40 to 1379 bp in length, and the introns from 97 bp to approximately 19.9 kb.
mRNA: size: ~8.7 kb.
Protein: under construction


Breast cancer


Cell lines:

Tumors:
- In a series of tissue extracts from 166 breast cancers, HGF content showed a strong positive correlation with von Willebrand factor content (Yao Y. et al., 1996).

- In a study of >200 invasive breast carcinomas, high IL-1 beta content in invasive carcinomas was significantly associated with higher contents of HGF, VWF, and TSP1 (Jin L. et al., 1997).



References

Bonthron D. et al. (1986) Nucleotide sequence of pre-pro-von Willebrand factor cDNA. Nucleic Acids Res. 14, 7125-7127.
Bonthron D.T. et al. (1986) Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature 324, 270-273.
Collins C.J. et al. (1987) Molecular cloning of the human gene for von Willebrand factor and identification of the transcription initiation site. Proc. Nat. Acad. Sci. USA 84, 4393-4397.
Jin L. et al. (1997) Expression of interleukin-1beta in human breast carcinoma. Cancer 80, 421-434.
Mancuso D.J. et al. (1989) Structure of the gene for human von Willebrand factor. J. Biol. Chem. 264, 19514-19527.
Ruggeri Z.M. et al. (1997) von Willebrand factor. J. Clin. Invest. 99, 559-564 (Review).
Sadler J.E. et al. (1985) Cloning and characterization of two cDNAs coding for human von Willebrand factor. Proc. Nat. Acad. Sci. USA 82, 6394-6398.
Yao Y. et al. (1996) Scatter factor protein levels in human breast cancers: clinicopathological and biological correlations. Am. J. Pathol. 149, 1707-1717.





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