Cell lines:
Tumors:
- The risk of developing breast cancer is higher in women presenting gross cystic disease (cysts > 3 mm in diameter) of the breast with intracystic K
+/Na
+ > 3 as compared with K
+/Na
+ < 3. The concentration of TNF-alpha, interleukin-1 (IL-1), and
interleukin-6 (IL-6) were determined in the breast cyst fluid of 54 women with gross cystic disease. No significant differences were found in the cystic levels of IL-1 between cysts with intracystic K
+/Na
+ < 3 and > 3. However, in cysts with intracystic K
+/Na
+ > 3 we found a lower concentration of
IL-6 and TNF-alpha than in those with intracystic K
+/Na
+ < 3. The concentration of
IL-6 in breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of TNF-alpha. The concentration of TNF-alpha in breast cyst fluid was predicted statistically by a positive regression coefficient for the concentration of
IL-6 (Herruzo A. et al., 1999).
Herruzo A. et al. (1999) Tumour necrosis factor-alpha and interleukin-1 and
-6 in fibrocystic breast disease. Breast Cancer Res. Treat. 54, 159-164.
