Steroid receptor coactivator-2
(SRC-2)

Other name(s)

Glucocorticoid receptor interacting protein 1 (GRIP1) (Hong H. et al., 1997)
Transcriptional intermediary factor 2 (TIF2) (Voegel J.J. et al., 1996)
Nuclear receptor coactivator-2 (NCoA-2)

Molecular biology

Gene: maps to ?
mRNA: size: 9.1 kb (Anzick S.L. et al., 1997).
Protein:

Breast cancer

Cell lines:
- By Northern blot analysis, expression of SRC-2 mRNA remained relatively constant in four ER-alpha-positive (BT-474, MCF-7, ZR-75-1, T-47D) and six ER-alpha-negative (MDA-MB-361, -436, -468, -453, BT-20, and UACC-812) BCC lines (Anzick S.L. et al., 1997).

- In a ligand-independent manner, the estrogen-related receptor (ERR) alpha-1 activity in SK-BR-3 BCC was induced 3-fold by cotransfection with a GRIP1 coactivator expression plasmid. The organochlorine pesticide toxaphene was found to be capable of suppressing the GRIP1 coactivator-induced ERR alpha-1 activity in these BCC (Yang C. and Chen S., 1999).

Tumors:

References

Anzick S.L. et al. (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277, 965-968.
Hong H. et al. (1997) GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol. Cell Biol. 17, 2735-2744.
Voegel J.J. et al. (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J. 15, 3667-3675.
Yang C. and Chen S. (1999) Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 59, 4519-4524.