SART-1

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Gene: maps to ?.
mRNA: size: 2.5 kb (Shichijo S. et al., 1998).
Protein: under construction.

Cell lines:

Tumors:
- The expression of the SART-1 gene encoding tumor rejection antigens was investigated in breast cancers. SART-1 mRNA was expressed in all of the samples tested. The SART-1(800) antigen was detectable in 20 of 50 (40%) breast cancer tissues and all breast cancer cell lines tested, but not in normal breast tissues. The SART-1(800)+ breast cancer cells transfected with HLA-A2601 or HLA-A2402 cDNA were recognized by the HLA-A26-restricted and SART-1-specific cytotoxic T lymphocytes (CTLs) or the HLA-A24-restricted and SART-1-specific CTLs, respectively. Among the 20 SART-1(800)+ tumors, 9 or 8 tumors expressed estrogen receptor or progesterone receptor, respectively (Kawamoto M. et al., 1999).

Kawamoto M. et al. (1999) Expression of the SART-1 tumor rejection antigen in breast cancer. Int. J. Cancer 80, 64-67.
Shichijo S. et al. (1998) A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J. Exp. Med. 187, 277-288.

Under construction