S100 calcium-binding
protein A6 (S100A6)

Calcyclin (Ferrari S. et al., 1987)

Gene: maps to 1q21-q25. It is present in single copy and has 3 exons (Ferrari S. et al., 1987).
mRNA: size:
Protein:

Cell lines:

Tumors:
- A series of primary breast tumors was collected and tested for expression of S100A4, S100A6 and S100 alpha/beta. All human breast-cancer tissues tested expressed S100A6, whereas the presence of S100A4 was more restricted. There was a significant correlation between enhanced expression of S100A4 and presence of the invasivity marker uPA (Pedrocchi M. et al., 1994).

- By immunohistochemistry, S100A4, S100A6, and S100B were found to be expressed at higher levels in cancer tissues than in normal tissues (Ilg E.C. et al., 1996).

Ferrari S. et al. (1987) Structural and functional analysis of a growth-regulated gene, the human calcyclin. J. Biol. Chem. 262, 8325-8332. (PubMed)
Ilg E.C. et al. (1996) Expression pattern of S100 calcium-binding proteins in human tumors. Int. J. Cancer 68, 325-332. (PubMed)
Pedrocchi M. et al. (1994) Expression of Ca(2+)-binding proteins of the S100 family in malignant human breast-cancer cell lines and biopsy samples. Int. J. Cancer 57, 684-690. (PubMed)

S100A4