Gene: maps to ?.
mRNA: size: 1.4 kb (Montano M.M. et al., 1999).
Protein: a 37-kDa
estrogen receptor (ER)-selective coregulator. Its competitive reversal of
steroid receptor coactivator 1 (SRC-1) enhancement of ER activity and its direct interaction with liganded ER suggest that it may play an important role in determining the sensitivity of estrogen target cells, including breast cancer cells, to antiestrogens and estrogens (Montano M.M. et al., 1999).
Montano M.M. et al. (1999) An
estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. Proc Natl Acad Sci USA 96, 6947-6952.
