P-cadherin

Placental cadherin

Gene: maps to .
mRNA: size:
Protein:

Cell lines:

Tumors:
- P-cadherin expression was found in some cases of infiltrating ductal carcinoma, and it was associated with reduced E-cadherin expression and advanced histological grade (Palacios J. et al., 1995).

- The expression of P-cadherin, E-cadherin, and N-cadherin, and alpha-catenin and beta-catenin was investigated in 183 cases of invasive breast carcinoma by immunohistochemistry on paraffin sections. P-cadherin was positive in 95 cases and negative in 88 cases of breast carcinoma. Positive P-cadherin expression in breast carcinoma showed a strong correlation with poor patient prognosis. Expression of N-cadherin, alpha-catenin, and beta-catenin did not correlate with patient survival. Multivariable statistical analyses of the data showed that expression of P-cadherin was independent of tumor size and lymph node metastases, but correlated inversely with estrogen/progesterone receptor status. In ductal carcinomas, positive P-cadherin expression correlated with a higher histologic grade. In contrast, expression of E-cadherin was low in high grade ductal carcinomas but negative tumors were uncommon. Negative or low E-cadherin expression did not correlate with poor survival. In lobular carcinomas, E-cadherin expression frequently was negative or low, and P-cadherin always was negative (Peralta Soler A. et al., 1999).

Palacios J. et al. (1995) Anomalous expression of P-cadherin in breast carcinoma. Am. J. Pathol. 146, 605-612.
Peralta Soler A. et al. (1999) P-cadherin expression in breast carcinoma indicates poor survival. Cancer 86, 1263-1272.

Under construction