Osteoclast differentiation factor
receptor (ODFR)

Receptor activator of NF-KappaB (RANK)

Gene: maps to 18q22.2 (Anderson D.M. et al., 1997).
mRNA: size: 3.1 kb (Anderson D.M. et al., 1997).
Protein: a TNF receptor family member. It may interact with ODF/RANKL/OPGL/TRANCE. Interaction between ODFR/RANK expressed by osteoclast precursors and ODF/RANKL/OPGL/TRANCE expressed by osteoblasts/stromal cells appears crucial for osteoclast differentiation in the presence of the cytokine M-CSF (Suda T. et al., 1999).

Cell lines:
- The breast cancer cell (BCC) lines MDA-MB-231, MCF-7, and T47D as well as primary breast cancers were shown to express OPG and ODFR/RANK, but not ODF/RANKL/OPGL/TRANCE (Thomas R.J. et al., 1999).

Tumors:

Anderson D.M. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390, 175-179.
Suda T. et al. (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20, 345-357.
Thomas R.J. et al. (1999) Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology 140, 4451-4458.