Cell lines:
- The phenotypic characteristics of 2 tumor cell lines (BC-H1 and BC-K1) established from bone marrow of patients with breast cancer were studied by immunocytochemistry, flow cytometry, and RT-PCR. Both cell lines expressed
E-cadherin,
vimentin, cytokeratins (including
component 18), alpha 5-,
alpha V-,
beta 1-, and
beta 3- integrin subunits,
ICAM-1,
MCAM, LFA-3 (CD58), and
CD44s (but not
CD44v5,
v6,
v7/8). BC-H1 also expressed
ErbB2 (not found in BC-K1), and MAGE-4 (but not MAGE-1, -2, -3/6, -12; BC-K1 was not tested). The expressed molecules might be potential candidates for novel therapeutic targets (Putz E. et al., 1999).
Tumors:
