KiSS-1

Other name(s)

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Molecular biology

Gene: KISS1 maps to 1q32 (West A. et al., 1998).
mRNA: size: 0.8-1.0 kb.
Protein: 164 aminoacids (aa); 18 kDa.

Breast cancer

Cell lines:
- Expression of KiSS1 in human breast carcinoma cells (MDA-MB-435) was shown to reduce their metastatic potential by 95% compared to control cells but did not suppress tumorigenicity. Thus, KiSS1 might function as a metastasis suppressor gene in at least some human breast cancers (Lee J.-H. and Welch D.R., 1997).

Tumors:

References

Lee J.-H. et al. (1996) Kiss-1, a novel human malignant melanoma metastasis-suppressor gene. J. Natl. Cancer Inst. 88, 1731-1737.
Lee J.-H. and Welch D.R. (1997) Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1. Cancer Res. 57, 2384-2387.
West A. et al. (1998) Chromosome localization and genomic structure of the KiSS-1 metastasis suppressorgene (KISS1). Genomics 54, 145-148.