Interleukin-18
(IL-18)

Interferon-gamma-inducing factor (IGIF)

Gene: IL-18 maps to 11q22.2-22.3 (Nolan K.F. et al., 1998)
mRNA: size: 1.1 kb (Ushio S. et al., 1996).
Protein: precursor: 192 aminoacids (aa); mature protein: 157 aa (18-19 kD). Interleukin-18 could be a potent angiogenesis and tumor suppressor (Cao R. et al., 1999).

Cell lines:

Tumors:

Cao R. et al. (1999) Interleukin-18 acts as an angiogenesis and tumor suppressor. FASEB J. 13, 2195-2202.
Nolan K.F. et al. (1998) The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51, 161-163.
Okamura H. et al. (1995) Cloning of a new cytokine that induces IFN-gamma production by T-cells. Nature 378, 88-91.
Ushio S. et al. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156, 4274-4279.

Under construction