Interleukin-17
(IL-17)

Cytotoxic T-lymphocyte-associated serine esterase 8 (CTLA-8)

Gene: IL-17 maps to 2q31 (Rouvier E. et al., 1993).
mRNA: size: 1.9 kb (Yao Z. et al., 1995).
Protein: a 155-amino acid, 17-kDa, variably glycosylated polypeptide containing an N-terminal hydrophobic signal sequence. Its amino acid sequence shares remarkable homology with that of the thirteenth open reading frame of herpesvirus saimiri, a virus causing T-cell lymphoma in monkeys and rabbits. Expressed recombinant IL-17 was found to be secreted in both glycosylated and nonglycosylated forms. IL-17 is expressed mainly by activated human memory CD4 T cells. IL-17 is considered to be a proinflammatory cytokine because it has been shown to increase the production of IL-6 and IL-8 in macrophages, fibroblasts, keratinocytes, and synovial cells. The release of stromelysin (MMP3) was also stimulated by rhIL-17 in human activated macrophages (Tartour E. et al., 1999).

Cell lines:

Tumors:

Jovanovic D.V. et al. (1998) Il-17 stimulates the production and expression of proinflammatory cytokines, Il-1-beta and TNF-alpha, by human macrophages. J. Immunol. 160, 3513-3521.
Rouvier E. et al. (1993) CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a Herpesvirus saimiri gene. J. Immun. 150, 5445-5456.
Tartour E. et al. (1999) Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res. 59, 3698-3704.
Yao Z. et al. (1995) Human IL-17: a novel cytokine derived from T cells. J. Immun. 155, 5483-5486.

Under construction