DR-nm23

???

Gene: maps to 16q13; consists in 6 exons and 5 introns; promoter very G+C rich, apparently TATA- and CAAT-less, but containing two putative AP-2 binding sites.
mRNA: sizes: 0.8-1.0 kb. DR-nm23 mRNA reveals an approximately 70% sequence similarity to the mRNA sequence of the nm23-H1 and nm23-H2 genes (Venturelli D. et al., 1995).
Protein: ~18 kD. 168 amino acids (aa) predicted from the cDNA. The protein has 66.9% and 64.9% aa sequence identity, respectively, to the human nm23-H1 and nm23-H2 proteins. A leucine zipper-like structure (aa 60 to 84) is present in DR-nm23, as also observed in nm23-H1 and nm23-H2 (Venturelli D. et al., 1995).

Under construction

Martinez R. et al. (1997) Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. Cancer Res. 57, 1180-1187.
Venturelli D. et al. (1995) Over-expression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocytic differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc. Natl. Acad. Sci. USA 92, 7435-7439.

nm23-H1, nm23-H2