Gene: CALLA maps to 3q21-q27. It spans more than 80 kb and is composed of 24 exons. The gene was not found rearranged in malignancies expressing cell surface CALLA. mRNA: size: kb Protein: CALLA is a 100-kD type II transmembrane glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. It cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Breast cancer
Cell lines:
- In addition to alpha6beta4, MDA-MB 231 breast cancer cells (BCC) exhibit other myoepithelial markers including cytokeratin 14, vimentin, and weak expression of CALLA (Jones J.L. et al., 1997).
Tumors:
References
Barker P.E. et al. (1989) The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3(q21-q27). J. Immun. 142, 283-287. D'Adamio L. et al. (1989) Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5-prime untranslated regions. Proc. Natl. Acad. Sci. USA 86, 7103-7107. Jones J.L. et al. (1997) Modulation of myoepithelial-associated alpha6beta4 integrin in a breast cancer cell line alters invasive potential. Exp. Cell Res. 235, 325-333. Letarte M. et al. (1988) Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase. J. Exp. Med. 168, 1247-1253. Shipp M.A. et al. (1989) Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ('enkephalinase'): direct evidence by cDNA transfection analysis. Proc. Natl. Acad. Sci. USA 86, 297-301.
