Gene: on chromosome .
mRNA: size: 4.4 kb
Protein: 120 kD. Cadherin-11 has never been shown to be expressed in E-cadherin-expressing cell lines or tissues. Cadherin-11 interacts with
beta-catenin in vitro (Shibata T. et al., 1996).
Cell lines:
- Cadherin-11 protein and mRNA have been found in the MCF-7/Adr, MDA-MB-157, -231, BT549, and Hs578T breast cancer cell (BCC) lines. All these BCC lines are invasive and fibroblastoid , express
vimentin, and do not express
ER, desmoplakin, and
E-cadherin. Cadherin-11 was not found in MDA-MB-175, -134, -435, -436, -453, -468, MCF-7, ZR-75-B, T-47D, BT-474, SK-BR-3, and CAMA-1 BCC lines. These lines are less invasive and do not express
E-cadherin (Pishvaian M.J. et al., 1999).
Tumors:
