A disintegrin and metalloproteinase
domain 11 (ADAM11)

Metalloproteinase-like, disintegrin-like, and cysteine-rich protein (MDC)

Gene: maps to 17q21.3 (Emi M. et al., 1993). It contains 28 exons and spans at least 23 kb. Exons 1a, 1b, 1c, 1d, and 2-7 encode a proprotein domain; exons 7-13, a metalloprotease-like domain; exons 14-17, a disintegrin domain; exons 18-22, a cysteine-rich domain, including an epidermal growth factor (EGF)-like repeat domain within exons 21 and 22; exon 23, a transmembrane domain; and exons 24 and 25, a short cytoplasmic domain (Katagiri T. et al., 1995).
mRNA:alternative splicing of the ADAM11 gene generates 2 transcripts with sizes of ~5 kb and ??? (Katagiri T. et al., 1995).
Protein: the longer mRNA encodes a protein of 769 amino acids; the other encodes a 524-amino acid isoform. ADAM11 is a metalloproteinase-like, disintegrin-like, and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions.

Cell lines:

Tumors:
- Somatic rearrangements of ADAM11 gene were found in two breast cancers. They involved multiple exons and disrupted the coding region (Emi M. et al., 1993).

Emi M. et al. (1993) A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. Nature Genet. 5, 151-157.
Katagiri T. et al. (1995) Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. Cytogenet. Cell Genet. 68, 39-44.