Mendel's Principles of Genetics
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Gregor Mendel: Father of Genetics (Czechoslovakia) Education: studied botany + mathematics Mendel's Pea Garden: Pure breeding: achieved through self-fertilisation for many generations Pea good: self-fertilising with stamens (male) & carpels (female) 7 famous pea traits: compare any two traits only at once to observe + maths seed shape seed colour seed coat colour pod shape pod colour flower position stem length
Observations: seed colour: P --> F1 hybrids: yellow, no green --> F2: Y:G(green) 3:1 ratio, green reappears Dihybrid cross: two heterozygous traits are produced --> F1 hybrid: 2 heterozygous traits --> self-pollinate --> prediction using Punnett Square
Findings: Dominance of yellow seeds over recessive green seeds --> Principle of Dominance (a type of heredity) At least 2 traits present in F1 generation: since F2 contains both G & Y, even though only Y seeds are phenotypical in F1 3:1 ratio in F2: can be explained by combinations of the two traits to give 4 possible combinations Probabilities: equal probabilities of passing alleles Law of Segragation: Parental genes separate --> gametes --> random combinations --> possible combinations probabilities Punnett Square: all gametes of parents --> all combinations for genetypes F1 generation: heterozygous --> F2: same Law of Indepedent Assortment: different traits are passed on independent of each other (proved wrong, due to co-existence of alleles on the same carrier gene --> depedent generation) 2 Heterozygous traits --> Punnett Square --> combinations 2^4=16 --> 9:3:3:1 for Dihybrid crosses based on assumption of independent assortment Genetics: Gene: a distinct unit of hereditary material Allele: one form of a gene --> trait Homozygote: all alleles are the same Heterozygote: not all alleles are same --> different alleles Genotype: genetic make-up of genes, alleles Phenotype: physical trait expressed or presented in appearance Gamete: half of all alleles of parent cell
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