The central hypothesis of this proposal is that objective quantitation of myocardial perfusion and coronary flow reserve can be achieved using 82Rb imaging and, furthermore, that these measures are important determinants of clinical risk and, thus, useful for optimizing management decisions in patients with coronary artery disease (CAD). We use dynamic 82Rb PET along with innovative approaches based on generalized factor analysis of dynamic sequences (GFADS), that allow automatic estimation of left and right ventricle input functions, as well as region-based compartment analysis to characterize and quantify the coronary flow reserve (CFR) as well as the severity and extent of perfusion abnormalities that occur in CAD.
Related Papers:
El Fakhri G., Kardan A., Sitek A., Dorbala S., Abi-Hatem N., Lahoud Y., Fischman A.J., Coughlan M., Yasuda T., Di Carli M.F. Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment Using 82Rb-PET: Comparison with 13N-Ammonia. J. Nucl. Med. 2009; in press.
Anagnostopoulos C., Almonacid A., El Fakhri G., Currilova Z., Sitek A., Roughton M., Dorbala S., Popma J., Di Carli M. Quantitative Relationship Between Coronary Vasodilator Reserve Assessed by Rubidium-82 PET Imaging and Coronary Artery Stenosis Severity. Eur. J. Nucl. Med. Mol. Imag. 2008; 35: 1593-1601.
Di Carli M.F., Dorbala S., Meserve J., El Fakhri G., Sitek A., Moore S.C. Clinical myocardial perfusion PET-CT. J. Nucl. Med; 2007; 48: 783-793.
El Fakhri G., Sitek A., Gu�rin B., Kijewski M.F., Di Carli M.F., and Moore S.C. Quantitative dynamic cardiac 82Rb-PET imaging using generalized factor and compartment analyses. J. Nucl. Med. 2005; 46: 1264-1271 (2006 Mosby-Year Book of Nuclear Medicine). [PDF]