We are bringing to fruition our successful developments of accurate compensation methods for physical factors affecting image quality and reconstruction approaches for quantitative dual-isotope SPECT, and are expanding our scope to PET. We are presently evaluating the performance of two novel scatter correction methods for quantitative single and dual-isotope PET that we have developed. We are also extending our previous work in SPECT to novel approaches to dual-isotope dynamic brain PET using spatio-temporal information. We are assessing the performance of quantitative dual-isotope SPECT and PET in activity estimation tasks related to early diagnosis and quantitation of disease extent in coronary artery disease (CAD) and early Parkinson disease (PD) with or without dementia.
Related Papers:
Trott C. and El Fakhri G. �Sequential and simultaneous dual-isotope brain SPECT: comparison with PET, for estimation and discrimination tasks in early parkisnon disease�. Med. Phys., 2008; 35: 3343-3353.
Ouyang J., Zhu X., Trott C., El Fakhri G. Quantitative simultaneous 99mTc/123I cardiac SPECT using MC-JOSEM Med. Phys. 2008; in press.
Ouyang J., El Fakhri G., Moore S.C. Fast Monte Carlo Simulation Based Joint Iterative Reconstruction for Simultaneous 99mTc/123I Brain SPECT Imaging. Med. Phys. 2007; 34: 3263-3272.
El Fakhri G., Habert M.O., Maksud P., Kas A., Malek Z., Kijewski M.F., and Lacomblez L.. Quantitative simultaneous 99mTc-ECD/123I-FP-CIT SPECT in Parkinson disease and multiple system atrophy. Eur. J. Nucl. Med. Mol. Imag. 2006; 33: 87-92.
El Fakhri G., Maksud P., Kijewski M.F., et al. Quantitative simultaneous 99mTc/123I SPECT: design study and validation with Monte Carlo simulations and physical acquisitions. IEEE Trans Nucl Sci 2002 ; 49: 2315-2321. [PDF]
El Fakhri G, Moore S.C, Maksud P, Aurengo A, Kijewski M.F. Absolute activity quantitation in simultaneous I-123/Tc-99m brain SPECT. J Nucl Med 2001; 42: 300-308. [PDF]