Wobbler's Syndrome
by Bruce R. Wittels, D.V.M.
This is the first in a series of articles that will discuss specific disease
entities of bone caused, in part, by improper or overnutrition. Some of the
information to be presented in this and future articles will have been discussed
previously but will be put into specific consideration to the disease entity
covered. It is my desire to provide an understanding of the total picture of
proper nutrition and a well balanced and strong skeleton upon which these modern
day giants are to support their massive bodies. If the foundation of any
structure is weak, then the weight which is born by it will cause this
foundation to break and fall.
The principal breed affected with Wobbler's Syndrome is the Great Dane. Cervical
Spondylopathy or Canine Wobblers Syndrome as the lay person knows it, consists
of any uncoordination or lameness caused by pressure on the spinal cord as it
travels through the neck (at any age for any reason).
In Great Danes, a true wobbler is usually seen between the ages of 3-12 months
of age. The outstanding symptom is a slowly developing, progressive,
uncoordination and paralysis of the hind limbs. This paresis and/or
uncoordination is caused by pressure on the spinal cord as it passes thru the
vertebrae of the neck, the last three being the most prominent sites. The animal
may appear clumsy, "wobbling" or display swaying of the rear legs. On
slick surfaces it may be difficult or impossible to walk. The dog may fall when
attempting to turn and the toes of the hind feet may drag when walking. The dog
usually has its legs spread out as far as possible trying to better balance
itself. Initially front leg involvement is minimal or undetectable. As the
disease progresses, a characteristic short choppy rolling stride is seen on what
appears to be somewhat rigid forelimbs. As the compression of the spinal cord
becomes more severe, the front legs can have the same signs as the rear legs.
There is usually little or no neck pain but the dog may stand with the neck
flexed which usually alleviates some of the spinal cord pinching. Many dogs will
object to neck manipulation and may even collapse when the movement is forced.
On occasion, there can be an acute onset of signs. They are usually more severe
than with the progressive type. Forelimb involvement is usually present. There
is also a higher incidence of neck pain with the acute onset. This type of
wobblers is seen most frequently in five to seven year old Doberman Pinchers and
is rarely seen in young Danes. This must be differentiated from similar signs
caused by cervical disc protrusion or a fractured vertebrae.
The pressure of the spinal cord is due to improper formation of the anatomical
parts surrounding the spinal cord during growth. The pressure can be due to one
or a combination of the following:
1. weak
ligaments which hold the vertebral bodies in place - this allows
irregular movement of the vertebral bodies as the neck is placed in various
positions (subluxations) and causes a pinching of the spinal cord.
2. hyperplasia
of the yellow ligaments - normally these are thin loose elastic sheets
located between the arches of adjacent vertebrae. Just beneath them is the small
epidural space which is immediately above the spinal cord. With enlargement of
these ligaments, the epidural space is obliterated and the yellow ligaments push
directly on the spinal cord.
3. malformation
of the vertebrae - this can happen in various ways i.e.:
a. Vertibral
or spinal canal that is too small for the diameter of the spinal cord
b. Assymetric
cartilage defects which cause vertebral subluxations
c. Osteochondrosis
of the articular facets which also lead to subluxations
d. Stenosis
of the cranial orifices of vertebral foramina which causes a pinching of the
nervous system
DIAGNOSIS
This is based on the breed, age, history and results of both a physical and
neurological examination. Diagnosis is confirmed by radiographic examination. A
minimum of three views should be taken: a side view with the neck in normal
position, a side view with the neck in a flexed position (head pointed towards
the feet), and a side view with the head in a skyward position. A subluxation of
one or more vertebrae may be the only causative agent and is often only seen
when the neck is in and extended or flexed position. At times, a view of the
neck from top to bottom must be taken. A myelogram might be needed to properly
determine the exact compression sites. Other disease entities which can cause
similar symptoms that must be differentiated from are: disc protrusions,
infectious, neoplastic, vascular, or traumatic disorders of the spinal cord.
Other bone disorders common to the giant breeds can cause gait abnormalities but
are usually presented with a lot of pain and do not show any nervous system
involvement.
CAUSES
The exact reasons why the aforementioned vertebral abnormalities occur are
unknown. There is probably a genetic factor that comes into play. This is
determined by a high incidence of Canine Wobblers seen in certain families of
Danes. It is difficult to separate the genetic from the environmental factor
(nutrition, management and activity) as most of these families are kept in the
same environments because many breeders keep the pups for three to four months
thus keeping the family under a similar environment. Deformity and displacement
of the cervical vertebrae secondary to a long neck, large head and rapid growth
has been proposed. (Weight et al 1973).
A vertebral canal that is too small for the diameter of the spinal cord could
easily be caused by nutritional hypercalcitonism. As discussed in my second
article, Nutrition of the Newly Born and Growing Individuals (GDR
Jan/Feb '85). Calcitonin is released from the thyroid gland when the animal is
fed a diet high in calcium. Its function is to retard bone reabsorption and thus
decrease blood calcium levels. Remember, calcium is kept within strict limits in
the blood stream. In normal growth, expansion of the spinal canal must be
perfectly synchronized with growth of the spinal cord. Expansion is achieved by
resorption of bone inside the vertebral canal. With hypercalcitonism, the
retarded rate of bone resorption prevents proper expansion of the canal -
therefore the diameter of the spinal canal is decreased and has an irregular
contour. The spinal cord grows independently of the surrounding bone and is thus
pinched by the nonresorbed bone therefore causing Cervical Spondylopathy.
Nerves leave the spinal cord, to go to other parts of the body, through spaces
formed by notches is the vertebrae called foramina. A narrowness in these spaces
will cause a pinching of the nerves leaving the spinal cord which in turn causes
inflammation and swelling of the spinal cord itself thus causing wobblers
syndrome. Hypercalcitonism causes narrowness in the vertebral canal can also
yield a stenosis of the cranial orifices of the vertebral foramina due to its
effect of slowing bone resorption. Hyper or overnutrition can also give the same
results as an increased growth rate without proper mineralization and body
controls can cause enlarged or asymmetric bone formation of the vertebrae in the
neck as well as in any other bone in the body. This could easily result in
pinching of the nerves as an overabundance of bone can yield improper notch
formation.
Although the vertebrae may not be as flexible as other joints in the body - they
do move and have joint surfaces as do other bones. The joint surfaces called
"articular facets" are lined with a cartilage the same as those of
other joints. Improper formation of these surfaces can cause the vertebrae to
move improperly and cause luxation or subluxation which can cause pinching of
the spinal cord. A mechanism that can cause such a situation is Osteocondritis
Dessecans (OCD). For now, let's describe OCD as a disturbance of endochondral
ossification (one type of bone formation) which leaves the joint cartilage
thicker than normal. It is therefore further away from the blood supply leaving
it more susceptible to injury and cell death which will cause poor rotation of
the joint and hence subluxation. This can happen at all or only one of the
facets in the cervical spine. Again the last three vertebrae are most commonly
affected. Osteochondrosis will be more thoroughly discussed in the next issue of
the Reporter. The main cause of OCD is overnutrition or ad-lib feeding.
Hedhammer et all (1974) studied the relation between overnutrition and skeletal
disease in growing Great Danes. In general - dogs fed ad libitum had smaller
than cervical vertebral foramina (notches) with subsequent spinal cord
compression as well as asymmetric vertebral articular facets. There was also OCD
in the facets displayed as defects in the cartilage covering the facets. They
concluded that "excessive intake of food rich in protein, energy, calcium
and phosphorous accelerates growth and can induce various skeletal changes
including changes in the cervical vertebrae that result in the wobbler
syndrome."
TREATMENT
The treatment of cervical spondylopathy depends on the severity of the
neurological involvement and the longevity of the disease process. Treatment is
directed at stopping further cord trauma and at decreasing the current
neurological deficits.
The acute form of canine wobbler syndrome is truly a medical emergency. The dog
is very often quadriplegic and immediate veterinary attention must be sought in
order for the spinal cord to be saved. Generally the veterinarian will treat the
animal with diuretics (i.e. mannitol) and high dose steroids to decrease the
swelling and inflammation in the cord as well as ascorbic acid to protect the
myelin sheath that surrounds the nerves. This treatment may last as long as 2 to
3 days. Depending on the degree of improvement, decompressive surgery is usually
required to prevent further trauma to the cord. If via rigorous medical
treatment, the animal regains full neurological function, surgery may be delayed
from one to three weeks with the animal probably kept in a neck brace. If,
however, little or no improvement is rendered via medical care - surgery must be
done within a few days in order to preserve the integrity of the spinal cord.
The more time that passes with the spinal cord compressed and therefore without
nutrients and oxygen, the higher the likelihood of some degree of permanent
paralysis. The two most used surgical techniques are Dorsal Laminectomy (where
the top of the spinal canal is removed thus allowing the spinal cord to rise out
of the confining environment) and Ventral Decompression which removes ulcerated
disc material as well as certain ligaments under the spinal cord and some of the
vertebral body that may be compressing the cord. Choice of surgical technique is
made by the orthopedic surgeon or by someone that has had much experience with
spinal surgery as well as the special instrumentation needed for this
complicated procedure. Even with the correct facilities and techniques there are
always possibilities of post operative complications.
Dogs with slowly progressive signs of Wobblers Syndrome often respond well to a
combination of cage rest and corticosteroid therapy. I usually apply a neck
brace as well to provide some stabilization of the neck and at the same time
some traction as well. This is only if the syndrome is caught in the early
stages. Remember that the above will only alleviate the effects of compression
of the cord and does not and will not correct the vertebral and ligamentous
changes. The IMMEDIATE thing to do is to reduce the protein level of the diet. A
protein level not to exceed 22-24% should be fed. Any and all mineral
supplements should be discontinued. All food and water must be elevated to
further reduce neck tension. Ball playing or any action where the head is dipped
down to snatch up an object is to be eliminated. A very concerted effort to
restrain this dog from exercise is to be instituted as this can easily yield an
increase in the likelihood of vertebral subluxation or further damage to the
spinal cord. It is a known fact that signs of joint instabilities are less
severe in animals kept in a sedentary environment than those allowed
unrestricted exercise. Hopefully if this is discovered early and the diet is
changed while the bones are still forming and little recurrence of cord trauma
occurs, the remaining formation of bone will be normal and the condition can
stabilize itself to the point that surgery will not be needed. Surgery for the
slowly progressive form of cervical spondylopathy may not be as rewarding as
with the acute form, if it is discovered late since the damage to the spinal
cord may be permanent. It may however, prevent further damage to the cord.
What can we do to prevent canine wobblers syndrome? My own observations and
present studies indicate a probable genetic factor that may predispose certain
lines or individuals to producing wobbler offspring. You as breeders must
strongly consider the use of these lines or individuals for breeding purposes.
You must answer to your own conscience and morals. The goal of breeders and the
purpose of breeding is to strive to ever better the breed and those of you in
breeding solely for the monetary gain must seriously reconsider this motive!!!
One thing that we all must do is to refrain from that archaic urge to supplement
the excellent commercial foods available as the main cause of growing bone
disparities in the giant breeds is hypernutrition.. For those of you who have
found that one or two pups out of every litter or every other litter have shown
signs or have developed into wobblers, I recommend that you do your very best to
eliminate the environmental elements that might encourage or enhance the pups'
chances of developing into a wobbler. This would entail feeding the entire
litter the adult form of the high quality food (22%-24% protein) starting at
weaning time. Don't use Iams puppy food or A.N.F. 30 for instance. The extra
calcium and protein in these foods could easily cause signs of the above. I
would feed a multiple vitamin and absolutely no additives. Perhaps a little
canned food to increase the palatability. Each litter must be treated
individually. Don't equivocate your litter to your friend's. Don't ignore the
possibility that your dogs might be more efficient in digesting foods and
utilizing a higher percentage of available nutrients than someone elses. This
could give the same effect of overfeeding without the addition of any
supplements. Periodic radiographs may be advantageous to early detection of
wobbler development. Again it is very important to put as little stress on the
necks of these pups - directions to be followed as previously described.
SUMMARY
There is no cut and dry answer or definition as to why or where this disease
entity originates - this is a fairly new area of veterinary science. We are
finding strong evidence suggestive to a genetic entity in this syndrome and have
found definite proof that nutrition plays a major role in the development of
wobblers and other bone disorders in the giant breeds. Again this is due to our
wanting only the best for our dogs and knowing that the giant breeds need more
nutrition than average dogs. Where we tend to go wrong is in the belief that if
a little more is good, than a lot more must be better. Take an honest look at
your own feeding program and look for areas where you might be able to improve
the lives of your Danes.