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| Jason Lee | Dave | |
| Justin Long | Alvin | |
| Kaley Cuoco | Eleanor | |
| Christina Applegate | Brittany | |
| Tony Hale | Agent Suggs | |
| Jennifer Coolidge | Ms. Price | |
| Josh Green | Miles | |
| Jesse McCartney | Theodore | |
| Tracy Goode | Bus Driver | |
| Anna Faris | Jeanette | |
| Kimberly Williams-Paisley | Samantha | |
| Laura Marano | Hotel Baby Sitter | |
| Eddie Steeples | Barry | |
| John Lacy | Owner | |
| David DeSantos | Maitre'd |
| Director |
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| Producer | Arnon Milchan
Janice Karman |
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| Writer | Janice Karman
Ross Bagdasarian |
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| Cinematography | Peter Lyons Collister
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| Musician | Mark Mothersbaugh
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Through a series of misunderstandings, Alvin, Simon and Theodore come to believe that Dave is going to propose to his new girlfriend in New York City - and dump them. They have three days to get to him and stop the proposal. |
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