Characteristic Features of Minimal Change Nephrotic Syndrome vs Significant Glomerular Lesions Nephrotic Syndrome
| Features |
Minimal Lesion NS |
Significant lesion NS |
| Age |
Younger children mainly below 6 years |
Commoner in older children |
| Sex |
Predominance in males |
Similar sex incidence |
| Hematuria |
Rare |
Common |
| GFR |
Normal except with severe hypovolaemia | GFR is gradually reduced |
| Serum complement |
Normal |
Decreased in some types |
| Urinary protein selectivity |
Albumin |
Non selective |
| Renal biopsy |
Normal on light microscopy | Specific lesions with varying severity |
| Response to conticosteroid |
Good response in 90% | Poor response in most cases |
| Long term prognosis |
Good |
Majority will develop chronic renal failure |