Characteristic Features of Minimal Change Nephrotic Syndrome vs Significant Glomerular Lesions Nephrotic Syndrome
Features |
Minimal Lesion NS |
Significant lesion NS |
Age |
Younger children mainly below 6 years |
Commoner in older children |
Sex |
Predominance in males |
Similar sex incidence |
Hematuria |
Rare |
Common |
GFR |
Normal except with severe hypovolaemia | GFR is gradually reduced |
Serum complement |
Normal |
Decreased in some types |
Urinary protein selectivity |
Albumin |
Non selective |
Renal biopsy |
Normal on light microscopy | Specific lesions with varying severity |
Response to conticosteroid |
Good response in 90% | Poor response in most cases |
Long term prognosis |
Good |
Majority will develop chronic renal failure |