1600, At the battle of Sekigahara where the Western and Eastern Armies fought for control of Japan... a mysterious feared assassin named 'Demon Eyes Kyo'... a feared man who had reportedly killed over 1000 men and had bright burning red eyes. He was last seen at the battle where he stood between the two armies slaughtering all before him. Four years later a travelling medicine man named Mibu Kyoshiro meets a beautiful bounty hunter named Shiina Yuya who tries to bring Kyoshiro in for not paying for food. Before she can bring him in they are attacked by a monster... Defenseless against the monster there seems nothing they can do until Kyoshorio's eyes start glowing red... can this weak medicine man be the feared Demon Eyes Kyo?!?!?!.