Zheng Gu Shui is a red-brown clear liquid with aromatic
smell.
PHARMACOLOGICAL ACTION
Research on pharmacodynamics shows that:
1. Observations on the histology of mice fracture and osteotylus show
that Zheng Gu Shui can promote the curing of mice fracture when applied
externally.
2. Zheng Gu Shui can promote the healing of rat fracture, which shows
that it has the tendency to build up the resistance to fracture.
3. Zheng Gu Shui can obviously reduce the proportion of ecchymosis, which
shows that it can promote the absorption of local ecchymoma.
4. Zheng Gu Shui has an action of expanding rabbit auricular blood vessel.
5. Zheng Gu Shui has an action of greatly improving petechia and edema
caused by external injury to the foot.
6. Zheng Gu Shui has a certain inhibitory effect on mice auricle inflammation
induced by croton oil.
7. Zheng Gu Shui has an obvious anti-inflammatory effect on mice toe inflammation
induced by carrageenin.
8. Zheng Gu Shui can noticeably increase the threshold value of pain induced
by acetic acid.
Research on toxicology shows that:
1. Acute toxicity test:
1) Reaction on undamaged skin: 10ml of the medicine, applied with gauze,
were externally administered to rat¡¯s unhaired dorsal skin
with the area of 6 × 6cm2 within 24 hours. No death or abnormality
was observed in terms of rat¡¯s appetite, spirit or diachormea,
nor was it observed 7 days after suspension of this medicine.
2) Reaction on damaged skin: 10ml of the medicine, applied with gauze,
were externally administered within 24 hours to rat¡¯s unhaired
dorsal skin which was grazed by sandpaper until oozing of blood. Movements
increasing, slow respiration, dyspnea, loss of appetite, even death were
observed at different periods in large-dose, medium-dose and small-dose
groups. Nevertheless, no pathological changes on organs were found. It
is suggested that clinically damaged skin should avoid contact with Zheng
Gu Shui.
2. Skin irritation test: Results showed that no irritation reaction was
observed when undamaged skin was in contact with Zheng Gu Shui in a single
dose, and that no obvious irritation was observed 14 days after continuous
contact with Zheng Gu Shui. Back trembling, bleeding under crust and roughness
of skin were observed when damaged skin made contact with Zheng Gu Shui
in one or more than one dose, but no obvious erythema or edema were observed.
3. Allergic test: No allergic reaction was observed when Zheng Gu Shui
was externally used on the undamaged skin.
ACTIONS & COMPLAINTS
Action: Invigorating blood circulation and removing blood stasis, relaxing
and activating tendons, reducing swelling and easing pain. Complaints:
traumatic injury, various fracture, dislocating of joints. It can dissipate
fatigue before and after exercises.
DIRECTION & DOSAGE
Softly rub the affected area with cotton soaked with the tincture. In
severe cases, apply the cotton to the affected area for one hour, 2-3
times a day.
ADVERSE REACTION
Pruritus and rashes should appear occasionally.
STORAGE
Tightly sealed and kept in a cool place
PRECAUTIONS
Do not take this tincture orally. Do not rub on the
wound. Stop
administration if pruritus or rashes appear during
administration.
