This manuscript also extends on the human CSF study by showing that human narcolepsy brain tissues have no hypocretin-1 and 2 peptides. It also reports that human narcolepsy cases have no preprohypocretin transcripts in their hypothalami, an area containing the hypocretin cells.

First publication indicating that human narcolepsy is caused by a destruction of hypocretin-containing cells, published in Nature Medicine, September 1st 2000.

_{SOURCE: Stanford School of Medicine Center for Narcolepsy -Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S, Mignot E.
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med. 2000 Sep;6(9):991-7.}