| Jack | William Hurt |
| Anne | Christine Lahti |
| June | Elizabeth Perkins |
| Murray | Mandy Patinkin |
| Eli Blumfield | Adam Arkin |
| Nicky | Charlie Korsmo |
| Leslie Abbott | Wendy Crewson |
| Al Cade | Bill Macy |
| Ralph | J.E. Freemann |
| Mr. Maris | William Marquez |
| Alan | Kyle Secor |
| Sarah | Nicole Orth-Pallavicini |
| Jay-Jay | Ping Wu |
| Roger | Tony Fields |
| Michael | Brian Markinson |
| Lonnie | Maria Tirabassi |
| Pete | Ken Lerner |
| Tim | Bruce Jarchow |
| Joe | Keith Polk, M.D. |
| Nancy | Nellye Leonard, O.R.T. |
| Mr. Richards | Richard McKenzie |
| Young Patient | Denis Heames |
| Shirley | Sue Rihr |
| Nurse Jane | Brandin Artis |
| Carrie | Millie Slavin |
| Laurie | Nancy Parsons |
| Anthony | John Marshall Jones |
| Kristin | Laurie Lathem |
| Joey | Adam Wylie |
| Dominic | Stephen Moore |
| Barbara | Cynthia Mason |
| Joey's Mother | Breon Gorman |
| Lucy | Renee Victor |
| Max | Gregor Hesse |
| Admissions Secretary | Fran Bennett |
| Ward Nurse | Zoaunne LeRoy |
| Anesthesiologist | Jonathan Kohl, M.D. |
| M.R.I. Tech #1 | Ross Eto, M.D. |
| Builder | Michael O'Dwyer |
| Dr. Abbott's Receptionist | Karen S. Gregan |
| Mrs. Maris | Lillian Hurst |
| Mr. Maris' Mother | Rosa Maria Briz |
| Heart Transplant Surgeon | Steven Gundry, M.D. |
| June's Nurse | Akuyoe |
| Record Clerk | Jusak Bernhard |
| Priest | Nicholas Frangakis |
| Doctors in Hallway | Matthew T. Clancy, M.D.
Jeris Poindexter |
| Orderly | Derek van Longshore |
| O.R. Nurses
|
Gail Neely
Lily Mariye Woodryan Alexander, R.N. Susan Schelling Long |