Interaction Between NAT2 Genotype and Environmental Factors for Bladder Cancer 盧誌明 鍾孟珠 黃俊雄 葛應欽 高醫醫研所 大林慈院泌尿科 國衛院 高醫附醫泌尿科 Cigarette smoking, aromatic amines and ionizing radiation were known carcinogens of bladder cancer. NAT2 genotype might play a role in bladder cancer carcinogenesis. This hospital-based, case-control study was conducted in Kaohsiung, Taiwan, where neighbors the high incidence region of bladder cancer, black foot disease area. Total 103 cases with diagnosed bladder cancer were collected. For each case, one control was selected from the same hospital. A structured questionnaire was applied for all cases and controls. DNA was extracted from peripheral blood cell. ASO-PCR/RFLP technique was used to determine the NAT2 genotype. For bladder cancer, the significantly excessive risks were observed in regular drinkers (OR=2.74, 95%CI=1.28-5.87) and residents of black foot disease endemic area (OR=7.64, 95%CI=2.16-26.97), and interaction of regular drinking, duration of smoking more than 30 years, and slow type of NAT2 (OR=13.33, 95%CI=1.64-108.57). We suggested that NAT2 genotype might play a role of effect modifier in bladder cancer carcinogenesis.