1. Available immediately:

Detection and tolerization of autoimmune T cells.
Emphasis is on development and use of antigen-MHC-class II dimers on an Ig backbone (parallel technology to MHC tetramers) to identify, track and modulate the function of autoreactive T cells in an antigen-specific fashion. The work utilizes the model of experimental autoimmune uveitis (EAU) in wild-type and TCR-transgenic mice. Concepts and approaches are generalizable to other disease models.
 

2. Available in June 2001:

Genetics of susceptibility to autoimmune disease.
The focus is on analysis of quantitative trait loci affecting susceptibility to autoimmune uveitis in rats by using marker-assisted strain selection (“speed congenics”), and on immunological analysis of HLA-transgenic mice that express class II genes associated with disease susceptibility in humans.  Concepts and approaches are generalizable to other disease models.
 

Applicants must have a strong background in immunology and molecular biology or molecular biology and less than 5 years postdoctoral experience.

Stipend is $30,000 - $40,000 per year, commensurate with experience.

Contact:
Dr. Rachel Caspi,
Lab. Immunol., NEI, NIH,
10 Center Drive, 10/10N222,
Bethesda MD 20892-1857.

E-mail: [email protected]
Voice: (301) 435-4555
Fax: (301) 480-6668
Additional info on http://www.nei.nih.gov/intramural/imm-reg.htm.