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Project 23
Occupational Hazards of Women Employed in Brassware Industries of Aligarh & Moradabad in U.P. Sponsored by: Objectives as stated in the project proposal:
has drawn the attention of the scientists more so from the environmentalists because their relative vulnerability to the toxic hazards posed by the exposure to variety of exogenous substances, specially the heavy metals. Aligarh and Moradabad, the twin metal cities, are better known as metal
cities
The lapses in our knowledge of occupational and environmental hazards of women may largely be attributed to the fact that most of the epidemiological survey have been confined to male's occupation so far. But the underlying fact is that the occupation and/or environmental hazards are not uniformly distributed between males and females and therefore, it is all the more significant to understand such variation as well. A coherent effort is required to identify and quantify the magnitude
of occupational and environmental health hazards of the women engaged in
brassware factories of the twin
During the course of the study spread over a period of three years,
more than 1,475 factories located in different parts, mostly scattered
throughout the cities of
Epidemiological Data on the Occupational &
Environmental Hazards of Women Employed in Brassware Factories of Moradabad.
Parameter % Detectance Remarks, if any ------------------------------------------------------------------------------------ Anaemic 90 As per body weight & height. Menstrual disorder 62 Calculated from those who did not attain menopause (approx.70%) Hypertension 38 Diastolic Susceptibility to UTI 24 Most of them did not know Frequency of abortion/
Frequency of repeated
Infertility
4.6
It is not established whether
Table - 2 Epidemiological Data on the Occupational & Environmental Hazards of Women Employed in Brassware Factories of Moradabad. Parameter %Detectance Remarks, if any ------------------------------------------------------------------------------------ Foetal morbidity and 39 Only limited women mortality co-operated. Women with breathing
78
Women with grey hairs
60
Scanty grey hairs are not
Susceptibility to chronic
Eye sight defect
28
Most of them did not get
Dermatitis
34
Confined to hand and some
Table - 3 Epidemiological Data on the Occupational &
Environmental Hazards of Women Employed in Brassware Factories of Aligarh.
Parameter % Detectance Remarks, if any ------------------------------------------------------------------------------------ Anaemic 85 As per body weight & height. Menstrual disorder 68 Calculated from those who did not attain menopause (approx. 70%) Hypertension 59 Diastolic Susceptibility to UTI 48 Most of them did not know Frequency of abortion/
Frequency of repeated
Infertility
11
It is not established whether
Table - 4 Epidemiological Data on the Occupational & Environmental Hazards of Women Employed in Brassware Factories of Aligarh. Parameter % Detectance Remarks, if any ------------------------------------------------------------------------------------ Foetal morbidity and 47 Only limited women mortality co-operated. Women with breathing
85
Women with grey hairs
74
Scanty grey hairs are not
Susceptibility to chronic
Eyesight defect
36
Most of them did not get
Dermatitis
48
Confined to hand and some
Table - 20 Concentration of Heavy Metal in Placenta of
Women Occupationally
Metal Controls (Mean) Experimental (Mean) ------------------------------------------------------------------------------------ Fe 724.52 1059.08 Pb 45.72 68.11 Cd 2.58 3.04 Ni 17.61 24.42 Cu 12.84 19.63 Zn 72.00 85.16 ------------------------------------------------------------------------------------
Table - 21 Concentration of Heavy Metal in Breast Milk of Women Occupationally Exposed to Brassware Industries and from controls (in ppb). Metal Controls (Mean) Experimental (Mean) ------------------------------------------------------------------------------------ Fe 261.10 310.33 Pb 192.88 224.05 Cd 116.27 184.68 Ni 180.15 209.14 Cu 459.62 663.71 Zn 520.04 791.07 ------------------------------------------------------------------------------------
Table - 22 Effect of Lead on Human Placental ATPase Pb (Conc) Enzyme activity in µ moles of (Pi) (ppm) liberated / min / mg protein --------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------ Control 5.54 ± 0.09 0.1 5.17 ± 0.12 1.0 5.08 ± 0.86 5.0 4.65 ± 0.90 20.0 4.52 ± 0.95 ------------------------------------------------------------------------------------ Table - 23 Effect of Zinc on Human Placental ATPase Zn (Conc) Enzyme activity in µ moles of (Pi) (ppm) liberated / min / mg protein -------------------------------------------------- ( Mean ± S. E.) (N=8) ----------------------------------------------------------------------------------- Control 5.34 ± 0.62 0.1 5.41 ± 1.02 1.0 5.13 ± 0.85 5.0 4.94 ± 0.72 20.0 4.01 ± 0.98 ------------------------------------------------------------------------------------ Table - 24 Effect of Lead on Succinate Dehydrogenage Activity (SDH) in Human Placental Pb (Conc.) Enzyme activity in µ moles of K3Fe(CN)6 (ppm) reduced / min / mg protein -------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------- Control 0.120 ± 0.01 0.1 0.119 ± 0.06 1.0 0.124 ± 0.08 5.0 0.137 ± 0.11 20.0 0.145 ± 0.18 ------------------------------------------------------------------------------------- Table - 25 Effect of Zinc on Succinate Dehydrogenage Activity (SDH) in Human Placental Zn (Conc.) Enzyme activity in µ moles of K3Fe(CN)6 (ppm) reduced / min / mg protein -------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------ Control 0.120 ± 0.02 0.1 0.122 ± 0.05 1.0 0.130 ± 0.08 5.0 0.150 ± 0.12 20.0 0.131 ± 0.18 ------------------------------------------------------------------------------------ Table - 26 Effect of Lead on Malate Dehydrogenage Activity in Human Placental Pb (Conc.) Enzyme activity in µ moles of NADH (ppm) oxidized / min / mg protein --------------------------------------------------- ( Mean ± S. E.) (N=6) ------------------------------------------------------------------------------------ Control 108.54 ± 5.62 0.1 118.75 ± 4.13 1.0 120.42 ± 4.85 5.0 131.83 ± 6.11 20.0 133.05 ± 6.88 ------------------------------------------------------------------------------------ Table - 27 Effect of Zinc on Malate Dehydrogenage Activity in Human Placental Zn (Conc.) Enzyme activity in µ moles of NADH (ppm) oxidized / min / mg protein --------------------------------------------------- ( Mean ± S. E.) (N=6) ------------------------------------------------------------------------------------ Control 108.56 ± 5.66 0.1 103.44 ± 3.59 1.0 104.61 ± 2.86 5.0 102.07 ± 4.95 20.0 98.54 ± 5.22 ------------------------------------------------------------------------------------ Table - 28 Effect of Lead on Diaphorase Activity in Human Placental Pb (Conc.) Enzyme activity in µ moles of 2,6- dichlorophenol indophenol (ppm) reduced / min / mg protein -------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------ Control 60.21 ± 2.74 0.1 59.24 ± 1.48 1.0 61.82 ± 3.11 5.0 64.58 ± 3.65 20.0 62.46 ± 4.51 ------------------------------------------------------------------------------------ Table - 29 Effect of Zinc on Diaphorase Activity in Human Placental Zn (Conc.) Enzyme activity in µ moles of 2,6- dichlorophenol indophenol (ppm) reduced / min / mg protein -------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------ Control 60.21 ± 2.74 0.1 60.62 ± 3.05 1.0 59.74 ± 3.28 5.0 56.54 ± 4.13 20.0 52.48 ± 5.71 ------------------------------------------------------------------------------------ Table - 30 Effect of Lead on the Activity in Human Placental Aldose Reductase. Pb (Conc.) Enzyme activity in µ moles of NADPH (ppm) oxidized / min / mg protein (1x10-4) --------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------ Control 58.54 ± 0.6 0.1 65.32 ± 1.1 1.0 68.45 ± 0.9 5.0 89.52 ± 1.2 20.0 102.25 ± 2.4 Table - 31 Effect of Zinc on the Activity in Human Placental Aldose Reductase. Pb (Conc.) Enzyme activity in µ moles of NADPH (ppm) oxidized / min / mg protein (1x10-4) --------------------------------------------------- ( Mean ± S. E.) (N=8) ------------------------------------------------------------------------------------ Control 58.54 ± 0.65 0.1 60.73 ± 0.92 1.0 62.15 ± 1.07 5.0 61.08 ± 1.24 20.0 64.11 ± 2.26 ------------------------------------------------------------------------------------ ** "When you come to a sick person, say Hippocrates, it behoves you ask
what uneasiness he is under, what was the cause of it, how many days he
has been ill, how his belly stands and what food he eats, to i'd presume
to add one interrogation;
Ramazzini Occupation health hazards, and therefore, occupational diseases, are
present everywhere. A project on "Environment & Occupational
Hazards of Women Employed in Brassware Industries of Aligarh & Moradabad,
U.P." was initiated by
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