| 09/28/08 | 13:00ET | Panthers | -7 | Falcons |
| 09/28/08 | 13:00 ET | Broncos | -9.5 | Chiefs |
| 09/28/08 | 13:00ET | Titans | -3 | Vikings |
| 09/28/08 | 13:00 ET | Cardinals | +2 | Jets |
| 09/28/08 | 16:05 ET | Jaguars | -7.5 | Texans |
| 09/28/08 | 16:05 ET | Chargers | -8 | Raiders |
| 09/28/08 | 16:05 ET | Bills | >-8.5 | Rams |
| 09/28/08 | 20:15 ET | Eagles | -3 | Bears |