| 09/21/08 | 13:00 ET | Fortyniners | -3 | Lions | WIN: +15 |
| 09/21/08 | 13:00 ET | Falcons | -6 | Chiefs | WIN: +18 |
| 09/21/08 | 13:00 ET | Titans | -5 | Texans | WIN: +14 |
| 09/21/08 | 13:00 ET | Titans | Under 39 | Texans | LOSS: -4 |
| 09/21/08 | 13:00 ET | Bears | -3 | Buccaneers | LOSS: -6 |
| 09/21/08 | 15:15 ET | Bills | >-10 | Raiders | LOSS: -9 |
| 09/22/08 | 10:30 ET | Chargers | -9 | Jets | WIN: +10 |