| 09/14/08 | 13:00 ET | Packers | -3 | Lions | WIN: +20 |
| 09/14/08 | 13:00 ET | Titans | +2 | Bengals | WIN: +20 |
| 09/14/08 | 13:00 ET | Saints | Even | Redskins | LOSS: -5 |
| 09/14/08 | 13:00 ET | Giants | -9 | Rams | WIN: +19 |
| 09/14/08 | 15:15 ET | Cardinals | >-6.5 | Dolpins | WIN: +14.5 |
| 09/14/08 | 20:15 ET | Steelers | -6.5 | Browns | LOSS: -2.5 |