| 09/07/08 | 13:00 ET | Eagles | -8.5 | Rams | WIN: +26.5 |
| 09/07/08 | 13:00 ET | Steelers | -6.5 | Texans | WIN: +12.5 |
| 09/07/08 | 13:00 ET | Seahawks | +1 | Bills | LOSS: -23 |
| 09/07/08 | 15:15 ET | Chargers | -9.5 | Panthers | LOSS: -11.5 |
| 09/07/08 | 15:15 ET | Cardinals | >-2 | 49rs | WIN: +8 |
| 09/07/08 | 20:15 ET | Colts | -9.5 | Bears | LOSS: -25.5 |
| 09/08/08 | 20:15 ET | Broncos | -3 | Raiders | WIN: +23 |