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| Mastocytosis Information |
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| Mastocytosis Information |
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| 3. Prognosis The natural clinical course of mastocytosis is variable depending on age, organs involved, subtype of disease, other co-existing disorders (like allergies or other clonal myeloid disorders), and the response to therapy. The majority of all patients have a normal life-expectancy. In pediatric mastocytosis (cutaneous mastocytosis in most cases), the disease often (but not in all cases) resolves during, shortly before, or shortly after puberty. 4. Is Mastocytosis a Hereditary or Contagious Disorder ? Mastocytosis is a non-contagious disease of mast cells and their progenitor cells. In the vast majority of all cases, no other family members are affected or will develop mastocytosis during life. Familial mastocytosis is an extremely rare disorder with an estimated frequency of less than 1:1,000 among all patients with mastocytosis. 5. What are the Symptoms in Mastocytosis ? - Headache, - osteoporosis, - bone pain, - nausea, - urticaria, - flushing, - itching, - diarrhoea, - abdominal discomfort and cramping, - an ulcerative disease of the stomach, - hypotension, - anemia and coagulotpathy, - and severe anaphylactic reactions with shock. These symptoms can occur in any type of mastocytosis, and at any time during the course of disease. In some patients, symptoms are very mild, whereas in others, they are severe and require continuous medicines and sometimes immediate therapy, i.e. in anaphylaxis. 6. Symptoms of anaphylaxis Anaphylaxis results from massive and sudden release of mediators from mast cells (histamine). In small children, unresponsiveness and flaccidity may be the only signs. Older children and adults: - light-headed feeling due to a drop of the blood pressure. - breathing problems - dizziness - welling of the tongue and lips - flushing, - severe hypotension. |