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+ADw-title+AD4-EFFECT OF ASPIRIN DOSAGE AND ENTERIC COATING ON PLATELET REACTIVITY+ADw-/title+AD4-
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OF ASPIRIN DOSAGE AND ENTERIC COATING ON PLATELET REACTIVITY+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/b+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4APAAhAFs-if +ACE-supportEmptyParas+AF0APgAm-nbsp+ADsAPAAhAFs-endif+AF0APgA8-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4-Feng D,
et al. Am J Cardiol 1997 Jul 15+ADs-80(2):189-93.+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4APAAhAFs-if +ACE-supportEmptyParas+AF0APgAm-nbsp+ADsAPAAhAFs-endif+AF0APgA8-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4-BACKGROUND:
Although aspirin is effective in the prevention and treatment of cardiovascular
diseases, the optimal dose remains uncertain. The purpose of this study was to
compare the platelet inhibitory and prostacyclin-sparing effects of 2 doses (81
and 325 mg) and forms (enteric-coated and regular) of aspirin.+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4APAAhAFs-if +ACE-supportEmptyParas+AF0APgAm-nbsp+ADsAPAAhAFs-endif+AF0APgA8-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4-METHODS:
Since platelet reactivity has been reported to increase after strenuous
exercise, a known trigger of myocardial infarction, subjects were studied
following maximal treadmill exercise as well as at rest. Forty male healthy
subjects were evaluated using a randomized, double-blind, parallel study
design. Blood samples were obtained before and after maximal treadmill exercise
at baseline and after 7 days on aspirin therapy.+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4APAAhAFs-if +ACE-supportEmptyParas+AF0APgAm-nbsp+ADsAPAAhAFs-endif+AF0APgA8-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4-RESULTS:
Both enteric and regular aspirin in 81- and 325-mg dosages markedly inhibited
adenosine diphosphate and epinephrine-induced aggregation at rest and after
exercise. Aspirin also inhibited the platelet response to collagen as assessed
by a longer lag time to aggregation. The prolongation of lag time was greater
for 325 mg than for 81 mg (100+ADw-span style+AD0AIg-mso-spacerun: yes+ACIAPgAm-nbsp+ADs- +ADw-/span+AD4-7
vs 91+ADw-span style+AD0AIg-mso-spacerun: yes+ACIAPgAm-nbsp+ADs- +ADw-/span+AD4-7+ADs- p +AD0- 0.04, after
exercise). There were no significant dose-related differences in plasma
6-keto-prostaglandin F1alpha level+ADs- however, enteric-coated aspirin inhibited
the exercise-induced increase in 6-keto-prostaglandin F1alpha to a lesser
extent than regular aspirin.+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4APAAhAFs-if +ACE-supportEmptyParas+AF0APgAm-nbsp+ADsAPAAhAFs-endif+AF0APgA8-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4-CONCLUSION:
Although both doses (81 and 325 mg) and types (regular and enteric-coated) of
aspirin inhibited adenosine diphosphate and epinephrine-induced aggregation
equally, the 325-mg dose inhibited collagen-induced aggregation to a greater
extent than 81 mg. The greater platelet inhibition observed with 325 mg may be
clinically relevant in acute coronary syndromes characterized by plaque rupture
with extensive collagen exposure and platelet activation.+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4APAAhAFs-if +ACE-supportEmptyParas+AF0APgAm-nbsp+ADsAPAAhAFs-endif+AF0APgA8-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
+ADw-p class+AD0-MsoPlainText+AD4APA-span style+AD0-'mso-fareast-font-family:+ACI-MS Mincho+ACI-'+AD4-COMMENTS:
While this was an interesting study, how this would affect the clinical setting
is unknown. However, it is important to note that giving ASA in any dose or
type is absolutely essential in dealing with patients with acute coronary
syndrome.+ADw-o:p+AD4APA-/o:p+AD4APA-/span+AD4APA-/p+AD4-
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