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| COMPARATIVE MODELLING APPROACHES OF HYPOTHETICAL PROTEINS FROM SULFOLOBUS SOLFATARICUS--AN ARCHEAL SPECIES | ||||
| Sulfolobales are hyperthermophilic archeae which grow in terrestrial volconaic hot springs with an optimum pH of 2-3 and a optimum temperature of 75-80 C. Analysis of genomes from such bacteria can provide information about thermostability of certain cells in a higly acidic environment. Apart from its use as a highly thermostable species, it can also be used to metabolize certain highly toxic sulfur compounds. The bio molecules responsible for such an action could be inferred well by sequence and structural analysis using the well known bioinformatics approaches. We have considered one such protein (hypothetical protein) for our investigation, whose similarity with Molybdopterin Synthase is nearly 20%. Using the protein sequence , a structure was built using Comparative modelling approaches and structual analysis are carried out to validate the same and also to elucidate its function. For more details on sulfolobus solfataricus, click here |
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